1. Expression Of Ki-67 and MUC1 In mucoepidermoid carcinomas of young and adult patients: prognostic implications.
- Author
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Gonçalves CF, Morais MO, Alencar Rde C, Mota ED, Silva TA, Batista AC, and Mendonça EF
- Subjects
- Adolescent, Adult, Age Factors, Carcinoma, Mucoepidermoid secondary, Female, Humans, Immunoenzyme Techniques, Male, Neoplasm Recurrence, Local pathology, Prognosis, Salivary Glands, Minor pathology, Young Adult, Biomarkers, Tumor metabolism, Carcinoma, Mucoepidermoid metabolism, Ki-67 Antigen metabolism, Mucin-1 metabolism, Neoplasm Recurrence, Local metabolism, Salivary Glands, Minor metabolism
- Abstract
Mucoepidermoid cancer (MEC) is the most malignant neoplasm of minor salivary glands. The aim of this study was to compare the expression of Ki-67 and MUC1 and clinicopathological data of mucoepidermoid carcinoma (MEC) in minor salivary glands of young and adult patients. The MEC cases in patients under 25 years old (n=8) and over 26 year old (n=8) were matched by gender, location and TNM staging. Immunohistochemical analysis of Ki-67 and MUC1 was carried out and correlated with clinicopathological data. The expression of Ki-67 and MUC1 was similar between the groups, although a tendency towards higher Ki-67 and MUC1 expression was observed in the younger group. Despite no significant differences, survival time was shorter in adults (71.37±17.44 months) compared to the younger group (97.62±25.81). While no patient deaths or tumor recurrences were found in the younger patient group, the adult group presented recurrence in 25% of cases and one patient died. In conclusion, our findings showed that age can be an important factor in MEC prognosis., (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Published
- 2011
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