1. [C-erbB-2 oncogene amplification in breast cancer in correlation to steroid and epidermal growth factor receptor].
- Author
-
Manavi M, Czerwenka KF, Zeillinger R, Speiser P, Kury F, Steinhart U, Peschke M, Kubista E, and Reinold E
- Subjects
- Breast pathology, Breast Neoplasms pathology, Carcinoma, Intraductal, Noninfiltrating pathology, Female, Humans, Immunoenzyme Techniques, Lymph Nodes pathology, Lymphatic Metastasis, Neoplasm Staging, Receptor, ErbB-2, Biomarkers, Tumor genetics, Breast Neoplasms genetics, Carcinoma, Intraductal, Noninfiltrating genetics, ErbB Receptors genetics, Gene Amplification genetics, Proto-Oncogene Proteins genetics, Receptors, Estrogen genetics, Receptors, Progesterone genetics
- Abstract
The amplification grade of oncogene c-erbB-2 was examined by the polymerase-chain-reaction-method in DNA's of 56 primary mammary carcinomas. 26 (46.4%) of these showed the amplified oncogene c-erbB-2. In the strongly amplified cases, the expression of the c-erbB-2 oncoprotein was verifiable immunohistochemically. Between the progesterone receptor status (PR) and the amplified c-erbB-2 oncogene there was a statistically proven dependency. No correlation was observed between the amplified c-erbB-2 oncogene and the epidermal growth-factor receptor (EGFR).
- Published
- 1992