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Start Over Author "Shimbireva IB" Topic carcinoembryonic antigen
5 results on '"Shimbireva IB"'

1. [Immunomorphological characteristics of primary and recurrent breast neoplasms].

Author

Volchenko NN, Zavalishina LE, Shimbireva IB, and Frank GA

Subjects
Carcinoembryonic Antigen metabolism, Female, Humans, Immunohistochemistry, Proliferating Cell Nuclear Antigen metabolism, Receptor, ErbB-2 metabolism, Recurrence, Biomarkers, Tumor, Breast Neoplasms metabolism, Breast Neoplasms pathology, Carcinoembryonic Antigen analysis, Proliferating Cell Nuclear Antigen analysis, Receptor, ErbB-2 analysis
Abstract

Primary and recurring breast carcinomas do not differ in the expression of proliferating cell nuclear antigen (PCNA), C-erb-2 oncoprotein, carcinoembryonic antigen and trophoblastic antigen. The content of PCNA and C-erb-2 oncoprotein is twice as high in tumors with an unfavorable prognosis and the frequency of combination of these markers is much higher comparing to tumors with a good prognosis. more...

Published
1998

2. [The determination of the concentration of the carcinoembryonic and meconial antigens in the gastric juice of patients with stomach pathology].

Author

Krylov IuV, Pugachev KK, Zhavoronok SV, Shimbireva IB, and Perkovskiĭ GA

Subjects
Adult, Aged, Enzyme-Linked Immunosorbent Assay methods, Female, Gastritis, Atrophic diagnosis, Humans, Male, Middle Aged, Polyps diagnosis, Stomach Neoplasms diagnosis, Stomach Ulcer diagnosis, Antigens, Neoplasm analysis, Biomarkers, Tumor analysis, Carcinoembryonic Antigen analysis, Gastric Juice immunology, Stomach Diseases diagnosis
Abstract

Beta-I-MA and CEA concentration in gastric juice was studied in 74 patients with gastric pathology and healthy subjects. Elevated concentrations of beta-I-MA and CEA were found more often in the gastric juice of cancer patients and less often in that of patients without malignant pathology. No significant differences in the concentration of each antigen were found between the "cancer" and "polyp" groups. The combined use of the two test procedures was shown to sufficiently complement the CEA test. The difference in the probability of high concentrations of both antigens in gastric juice in cancer and low ones in other pathologies was highly significant (chi 2 = 15.3, p. 0.00015). more...

Published
1992

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3. [The paraneoplastic phenotype of human gastric glands studied using the carcinoembryonic antigen-specific lectin crustacin].

Author

Pugachev KK, Kalashnikov VV, Shimbireva IB, and Belous TA

Subjects
Cell Transformation, Neoplastic metabolism, Chronic Disease, Epithelium metabolism, Gastritis metabolism, Histocytochemistry, Humans, Immunoenzyme Techniques, Pepsinogens analysis, Phenotype, Stomach Neoplasms metabolism, Calcium-Binding Proteins, Carcinoembryonic Antigen analysis, Gastric Mucosa metabolism, Lectins, Paraneoplastic Syndromes metabolism
Abstract

The expression of CEA was studied with the help of rabbit antibody and CEA-specific lectin-krustacin in pepsinogen positive gastric glands near carcinomas and in gastric mucosa with intestinal metaplasia and dysplasia of the epithelium without neoplasia. CEA-krustacin was revealed in 20 out of 41 cases and CEA-antibody in 2 out of 41 cases of gastric glands in mucosa near carcinomas. The results of investigation discover the development in the gastric glands near carcinoma subcellular components. Paraneoplastic phenomenon was found in the majority of the cases. more...

Published
1990

4. [The use of immunochemical reactions in determining a cytological diagnosis].

Author

Shabalova IP, Pugachev KK, Shimbireva IB, and Rudneva EA

Subjects
Humans, Immunohistochemistry, In Vitro Techniques, Ascitic Fluid chemistry, Beta-Globulins analysis, Biomarkers, Tumor analysis, Carcinoembryonic Antigen analysis, Pleural Effusion metabolism
Abstract

Cytologic preparations of 56 samples of pleural fluid, of 31 samples of ascitic fluid, and 13 puncture biopsy specimens were examined in immunocytochemical tests. Carcinoembryonic antigen and trophoblastic beta 2-globulin were detected in the cytograms. Antibodies to carcinoembryonic antigen and trophoblastic beta 2-globulin employed in the tests did not react with the cells from benign exudation, because tumor cells, particularly glandular carcinoma ones, contain these markers in high concentrations. more...

Published
1990

5. [Immunohistochemical study of carcinoembryonic antigen (CEA) in normal and embryonic human tissues using a CEA-specific oncoprecipitin, krustacin].

Author

Pugachev KK, Kalashnikov VV, Kurika AV, Pavlenko AF, and Shimbireva IB

Subjects
Adult, Animals, Antibodies analysis, Brachyura, Carcinoembryonic Antigen immunology, Embryo, Mammalian analysis, Embryo, Nonmammalian, Fetus analysis, Glycoproteins, Humans, Immunoenzyme Techniques, In Vitro Techniques, Invertebrate Hormones immunology, Carcinoembryonic Antigen analysis, Invertebrate Hormones analysis, Precipitins
Abstract

Using immunoperoxidase technique, antibodies to CEA (Ab) were compared to a glycoprotein krustacin (Kr) extracted from Pagurus prideauxii, which has an ability to precipitate specifically CEA. It was found that Kr and Ab reacted in a similar manner with embryonic and normal gastrointestinal tissues, revealing practically identical localization of the antigen in the tissues and cells. It was possible, however, to note some quantitative and qualitative differences in the distribution of antigen, which showed that Kr and Ab reacted with different determinants of the CEA molecule. more...

Published
1988