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Your search keyword '"Karkhut, Andrew"' showing total 1 results
Start Over Author "Karkhut, Andrew" Topic carboxylic acid derivatives
1 results on '"Karkhut, Andrew"'

1. Synthesis and anticancer activity evaluation of 3-(4-oxo-2-thioxothiazolidin-5-yl)-1H-indole-carboxylic acids derivatives.

Author

Kryshchyshyn-Dylevych, Anna, Garazd, Myroslav, Karkhut, Andrew, Polovkovych, Sviatoslav, and Lesyk, Roman

Subjects
ACID derivatives, CARBOXYLIC acid derivatives, METHYL formate, INDOLE
Abstract

A mild and efficient method for the synthesis of 1-oxo-9H-thiopyrano[3,4-b]indole-3-carboxylic acids and dimerized 3-(4-carboxy-1H-3-indolyl)-2-propenoic acids via alkaline hydrolysis of 3-(rhodanin-5-yl)-1H-indole-2-carboxylic acids derivatives was elaborated. Anticancer activity screening in NCI60-cell lines assay allowed identification of 5-fluoro-3-(4-oxo-2-thioxothiazolidin-5-ylidenemethyl)-1H-indole-2-carboxylic acid methyl ester 2a with significant antimitotic activity at micromolar and submicromolar concentrations. [ABSTRACT FROM AUTHOR]

Published
2020
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