1. α‐Sila‐Dipeptides: Synthesis and Characterization.
- Author
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Minkovich, Boris, Ruderfer, Ilya, Kaushansky, Alexander, Bravo‐Zhivotovskii, Dmitry, and Apeloig, Yitzhak
- Subjects
- *
DIPEPTIDES , *ORGANIC synthesis , *X-ray crystallography , *AMINO group , *CARBONYL group - Abstract
Abstract: The first two α‐sila‐dipeptides, 7 and cyclo‐sila‐dipeptide 8, were synthesized and characterized by several methods, including X‐ray crystallography. Bulky t‐BuMe2Si substituents provide some kinetic stabilization to the synthesized molecules. 7 and 8 are the first examples of a “Si for C switch” in the central α‐position of an amino acid or a peptide, in which silicon is bonded to both the amino and the carbonyl groups. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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