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Your search keyword '"Shouang, Lan"' showing total 3 results
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3 results on '"Shouang, Lan"'

2. N-Heterocyclic Carbene (NHC) Organocatalytic One-Pot Reaction for the Enantioselective Synthesis of Fluoromethylated Chromenones

Author

Liangsen Huang, Yuchen Hou, Baoxu Wang, Jiajia Cheng, and Shouang Lan

Subjects
010405 organic chemistry, Organic Chemistry, Enantioselective synthesis, Substrate (chemistry), 010402 general chemistry, 01 natural sciences, Biochemistry, Combinatorial chemistry, Carbonyl group, 0104 chemical sciences, Stereocenter, chemistry.chemical_compound, chemistry, One pot reaction, Physical and Theoretical Chemistry, Carbene
Abstract

An efficient carbene organocatalyzed route to enantioenriched chromenones, bearing one tri- or difluoromethylated stereogenic center in the β position of the carbonyl group, from o-allyloxybenzaldehydes is described. The one-pot transition-metal-free transformation exhibits a broad substrate scope and excellent enantioselectivity.

Published
2018

3. Asymmetric Synthesis of Dihydronaphthalene‐1,4‐Diones via Carbene‐Catalyzed Stereodivergent Reaction.

Author

Zhao, Zhifei, Yang, Shuang, Lan, Shouang, Liu, Jinggong, Liu, Shuhua, and Fang, Xinqiang

Subjects
RACEMIC mixtures, BENZOIN, NATURAL products, ISOMERS, RACEMIZATION, ALDOLS, KINETIC resolution, ASYMMETRIC synthesis
Abstract

2‐Hydroxy‐2,3‐dihydronaphthalene‐1,4‐diones (HDNDs) are ubiquitous in natural products and bioactive molecules, but the rapid asymmetric construction of such scaffolds remains a significant challenge to date. Reported herein is the rapid construction of the above key units via carbene‐catalyzed benzoin reaction. The resolution technique of divergent reaction on racemic mixture (divergent RRM) was employed, affording both isomers of HDNDs in a one‐step fashion. Disubstituted substrates afford products with two contiguous quaternary stereocenters. A series of highly selective transformations on the products can be realized, and mechanistic studies indicate that the benzoin reaction is much faster than the racemization process and the aldol reaction. [ABSTRACT FROM AUTHOR]

Published
2019
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