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3 results on '"Chunhui Li"'

1. Assessing Molecular Epidemiology of Carbapenem-resistant Klebsiella pneumoniae (CR-KP) with MLST and MALDI-TOF in Central China

Author

Chunhui Li, Sidi Liu, Jia Wang, Qingya Dou, Xin Huang, Mingxiang Zou, Jie Li, Qun Yan, Zhong Peng, Yao Liu, Anhua Wu, Ximao Wen, Jun Yang, Liang Chen, Xiujuan Meng, Chenchao Fu, Wenen Liu, Xun Huang, and Juping Duan

Subjects
0301 basic medicine, Male, China, Carbapenem resistant Klebsiella pneumoniae, lcsh:Medicine, Central china, Drug resistance, Biology, Article, Teaching hospital, Microbiology, Disease Outbreaks, 03 medical and health sciences, 0302 clinical medicine, Drug Resistance, Bacterial, Humans, lcsh:Science, Retrospective Studies, Molecular Epidemiology, Multidisciplinary, Molecular epidemiology, lcsh:R, Ms analysis, Outbreak, Klebsiella Infections, Klebsiella pneumoniae, 030104 developmental biology, Carbapenems, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Multilocus sequence typing, lcsh:Q, Female, 030217 neurology & neurosurgery
Abstract

Carbapenem-resistant K. pneumoniae (CR-KP) posts significant public health challenge worldwide. The aim of this study is to assess clinical characteristics and molecular epidemiology of CR-KP infections with Multilocus sequence typing (MLST) and Matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF) in Central China. A total of 71 CR-KP isolates were recovered in a teaching hospital from October 2014 to December 2015. Among all CR-KP isolates, 73.2% (52) produced K. pneumoniae carbapenemases-2 (KPC-2). Eighteen ST types were identified by MLST, among these ST types, forty-seven isolates belonged to ST11 type, which was the predominant outbreak strain in China, and most ST11 isolates produced KPC-2. Eleven mass spectrometry (MS) types were identified by MALDI-TOF MS analysis, 53.5% isolates were MS4 and MS6, which matched with ST11 in MLST analysis. CR-KP infection was associated with increased medical cost and longer hospitalization. Therefore, we found that KPC-2-producing ST11 (MS4 and MS6) CR-KP isolates were the predominant clone identified by MLST and MALDI-TOF, and CR-KP infection was associated with increased hospital costs and longer hospitalization.

Published
2019

2. Risk factors and medical costs for healthcare-associated carbapenem-resistant Escherichia coli infection among hospitalized patients in a Chinese teaching hospital.

Author

Xiujuan Meng, Sidi Liu, Juping Duan, Xun Huang, Pengcheng Zhou, Xinrui Xiong, Ruie Gong, Ying Zhang, Yao Liu, Chenchao Fu, Chunhui Li, Anhua Wu, Meng, Xiujuan, Liu, Sidi, Duan, Juping, Huang, Xun, Zhou, Pengcheng, Xiong, Xinrui, Gong, Ruie, and Zhang, Ying

Subjects
DRUG resistance in bacteria, CARBAPENEMS, ESCHERICHIA coli diseases, ESCHERICHIA coli, MEDICAL care costs, PUBLIC health, DISEASE risk factors, ACADEMIC medical centers, ANTI-infective agents, ANTIBIOTICS, CROSS infection, DRUG resistance in microorganisms, HEMOGLOBINS, LENGTH of stay in hospitals, HYPERGLYCEMIA, MULTIVARIATE analysis, TRACHEOTOMY, URINARY organ diseases, LOGISTIC regression analysis, SPECIALTY hospitals, DISEASE incidence, RETROSPECTIVE studies, CASE-control method, CENTRAL venous catheterization, ECONOMICS
Abstract

Background: The emergence and spread of Carbapenem-resistant Escherichia coli (CREC) is becoming a serious problem in Chinese hospitals, however, the data on this is scarce. Therefore, we investigate the risk factors for healthcare-associated CREC infection and study the incidence, antibiotic resistance and medical costs of CREC infections in our hospital.Methods: We conducted a retrospective, matched case-control-control, parallel study in a tertiary teaching hospital. Patients admitted between January 2012 and December 2015 were included in this study. For patients with healthcare-associated CREC infection, two matched subject groups were created; one group with healthcare-associated CSEC infection and the other group without infection.Results: Multivariate conditional logistic regression analysis demonstrated that prior hospital stay (<6 months) (OR:3.96; 95%CI:1.26-12.42), tracheostomy (OR:2.24; 95%CI: 1.14-4.38), central venous catheter insertion (OR: 8.15; 95%CI: 2.31-28.72), carbapenem exposure (OR: 12.02; 95%CI: 1.52-95.4), urinary system disease (OR: 16.69; 95%CI: 3.01-89.76), low hemoglobin (OR: 2.83; 95%CI: 1.46-5.50), and high blood glucose are associated (OR: 7.01; 95%CI: 1.89-26.02) with CREC infection. Total costs (p = 0.00), medical examination costs (p = 0.00), medical test costs (p = 0.00), total drug costs (p = 0.00) and ant-infective drug costs (p = 0.00) for the CREC group were significantly higher than those for the no infection group. Medical examination costs (p = 0.03), total drug costs (p = 0.03), and anti-infective drug costs (p = 0.01) for the CREC group were significantly higher than for the CSEC group. Mortality in CREC group was significantly higher than the CSEC group (p = 0.01) and no infection group (p = 0.01).Conclusion: Many factors were discovered for acquisition of healthcare-associated CREC infection. CREC isolates were resistant to most antibiotics, and had some association with high financial burden and increased mortality. [ABSTRACT FROM AUTHOR]

Published
2017
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3. Risk factors and medical costs for healthcare-associated carbapenem-resistant Escherichia coli infection among hospitalized patients in a Chinese teaching hospital

Author

Xiujuan Meng, Chunhui Li, Ruie Gong, Anhua Wu, Juping Duan, Chenchao Fu, Yao Liu, Xinrui Xiong, Xun Huang, Sidi Liu, Pengcheng Zhou, and Ying Zhang

Subjects
0301 basic medicine, Male, Carbapenem, medicine.medical_treatment, Antibiotics, Disease, Tertiary Care Centers, Hemoglobins, Medical microbiology, Tracheostomy, Anti-Infective Agents, Risk Factors, Child, Escherichia coli Infections, Aged, 80 and over, Cross Infection, Incidence (epidemiology), Incidence, CREC, Health Care Costs, Middle Aged, Anti-Bacterial Agents, Infectious Diseases, Child, Preschool, Female, Central venous catheter, medicine.drug, Research Article, Adult, Urologic Diseases, medicine.medical_specialty, Catheterization, Central Venous, China, Adolescent, medicine.drug_class, 030106 microbiology, Drug Costs, 03 medical and health sciences, Young Adult, Antibiotic resistance, Internal medicine, Drug Resistance, Bacterial, medicine, Humans, Healthcare-associated infection, Intensive care medicine, Hospitals, Teaching, Aged, Retrospective Studies, business.industry, CSEC, Infant, Newborn, Infant, Length of Stay, Logistic Models, Carbapenems, Case-Control Studies, Hyperglycemia, Tropical medicine, Multivariate Analysis, business
Abstract

Background The emergence and spread of Carbapenem-resistant Escherichia coli (CREC) is becoming a serious problem in Chinese hospitals, however, the data on this is scarce. Therefore, we investigate the risk factors for healthcare-associated CREC infection and study the incidence, antibiotic resistance and medical costs of CREC infections in our hospital. Methods We conducted a retrospective, matched case–control–control, parallel study in a tertiary teaching hospital. Patients admitted between January 2012 and December 2015 were included in this study. For patients with healthcare-associated CREC infection, two matched subject groups were created; one group with healthcare-associated CSEC infection and the other group without infection. Results Multivariate conditional logistic regression analysis demonstrated that prior hospital stay (

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