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Start Over Author "E. Caldiroli" Topic carbamazepine
5 results on '"E. Caldiroli"'

1. Effects of carbamazepine on human PMN function: possible role of peripheral benzodiazepine receptors.

Author

Caldiroli E, Fietta AM, De Ponti F, Cosentino M, Marino F, Taddei M, Lecchini S, and Frigo GM

Subjects
Adult, Benzodiazepinones pharmacology, Candida albicans, Chemotaxis, Leukocyte physiology, Humans, In Vitro Techniques, Isoquinolines pharmacology, Lipopolysaccharides pharmacology, N-Formylmethionine Leucyl-Phenylalanine pharmacology, Neutrophils drug effects, Phagocytosis physiology, Receptors, GABA-A drug effects, Carbamazepine pharmacology, Chemotaxis, Leukocyte drug effects, Neutrophils physiology, Phagocytosis drug effects, Receptors, GABA-A blood
Published
1997
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2. Carbamazepine affects neutrophil function through an action on peripheral benzodiazepine receptors.

Author

Caldiroli E, De Ponti F, Cosentino M, Marino F, Fietta AM, Taddei M, Tartara A, Zibetti A, Mazzone A, Lecchini S, and Frigo GM

Subjects
Adolescent, Adult, Aged, Benzodiazepinones pharmacology, Carbamazepine administration & dosage, Cells, Cultured, Chemotaxis, Leukocyte drug effects, Convulsants pharmacology, Drug Administration Schedule, Epilepsy drug therapy, Epilepsy immunology, Female, Humans, Isoquinolines pharmacology, Male, Middle Aged, Neutrophils immunology, Carbamazepine pharmacology, Neutrophils drug effects, Receptors, GABA-A drug effects
Abstract

The aims of this study were to assess the possible role of peripheral benzodiazepine receptors (pBZrs)1 in mediating the in vitro effects of carbamazepine (CBZ) on some neutrophil functions in healthy volunteers and to investigate neutrophil function and pBZr expression in patients with epilepsia on CBZ monotherapy for at least 1 year. In vitro CBZ (42-168 microM) concentration-dependently inhibited chemotaxis induced by N-formyl-methionyl-leucyl-phenylalanine (FMLP) or lipopolysaccharide (LPS)-activated human serum. CBZ did not affect random migration, phagocytosis index, phagocytosis frequency, NBT reduction frequency, C. albicans lethality index and resting superoxide production. The pBZr antagonist PK 11195 (1 microM, per se ineffective) reversed the inhibitory effect of CBZ on chemotaxis induced by endotoxin-activated serum or FMLP. The pBZr agonist Ro 5-4864 (10-100 microM) mimicked the effect of CBZ on chemotaxis induced by endotoxin-activated serum or FMLP and had no effect on the other parameters. Neutrophils from epileptic patients on chronic CBZ monotherapy had impaired FMLP- and serum-induced chemotaxis and enhanced expression of pBZrs on neutrophils. These data strongly suggest an involvement of pBZrs in mediating the in vitro effects of CBZ on chemotaxis; furthermore, impairment of the same neutrophil function parameters and overexpression of pBZrs in patients are consistent with the hypothesis of an in vivo interaction of CBZ with pBZrs.

Published
1997
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3. Carbamazepine Affects Neutrophil Function through an Action on Peripheral Benzodiazepine Receptors

Author

Antonino Mazzone, De Ponti F, M. Taddei, Marco Cosentino, A. Tartara, G. M. Frigo, A. Zibetti, Franca Marino, Anna Fietta, Sergio Lecchini, and E. Caldiroli

Subjects
Adult, Male, Agonist, medicine.medical_specialty, PK-11195, Adolescent, Lipopolysaccharide, Neutrophils, medicine.drug_class, Phagocytosis, Immunology, Convulsants, Granulocyte, Toxicology, Drug Administration Schedule, chemistry.chemical_compound, Internal medicine, medicine, Humans, Immunology and Allergy, Cells, Cultured, Aged, Pharmacology, Benzodiazepinones, Epilepsy, business.industry, Antagonist, Chemotaxis, General Medicine, Middle Aged, Isoquinolines, Receptors, GABA-A, Chemotaxis, Leukocyte, Carbamazepine, Endocrinology, medicine.anatomical_structure, chemistry, Mechanism of action, Female, medicine.symptom, business
Abstract

The aims of this study were to assess the possible role of peripheral benzodiazepine receptors (pBZrs)1 in mediating the in vitro effects of carbamazepine (CBZ) on some neutrophil functions in healthy volunteers and to investigate neutrophil function and pBZr expression in patients with epilepsia on CBZ monotherapy for at least 1 year. In vitro CBZ (42-168 microM) concentration-dependently inhibited chemotaxis induced by N-formyl-methionyl-leucyl-phenylalanine (FMLP) or lipopolysaccharide (LPS)-activated human serum. CBZ did not affect random migration, phagocytosis index, phagocytosis frequency, NBT reduction frequency, C. albicans lethality index and resting superoxide production. The pBZr antagonist PK 11195 (1 microM, per se ineffective) reversed the inhibitory effect of CBZ on chemotaxis induced by endotoxin-activated serum or FMLP. The pBZr agonist Ro 5-4864 (10-100 microM) mimicked the effect of CBZ on chemotaxis induced by endotoxin-activated serum or FMLP and had no effect on the other parameters. Neutrophils from epileptic patients on chronic CBZ monotherapy had impaired FMLP- and serum-induced chemotaxis and enhanced expression of pBZrs on neutrophils. These data strongly suggest an involvement of pBZrs in mediating the in vitro effects of CBZ on chemotaxis; furthermore, impairment of the same neutrophil function parameters and overexpression of pBZrs in patients are consistent with the hypothesis of an in vivo interaction of CBZ with pBZrs.

Published
1997
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4. Peripheral benzodiazepine receptor expression on leukocytes and neutrophil function during anticonvulsant monotherapy

Author

E. Caldiroli, G. M. Frigo, Franca Marino, Sergio Lecchini, Marco Cosentino, Antonino Mazzone, A. Zibetti, Anna Fietta, and F. De Ponti

Subjects
Phenytoin, Adult, Male, Adolescent, medicine.drug_class, Neutrophils, medicine.medical_treatment, Receptor expression, Pharmacology, medicine, Leukocytes, Humans, Lymphocytes, Aged, Benzodiazepine, Valproic Acid, Epilepsy, GABAA receptor, Chemistry, hemic and immune systems, Chemotaxis, General Medicine, Carbamazepine, Middle Aged, Receptors, GABA-A, Anticonvulsant, Anticonvulsants, Female, medicine.drug
Abstract

Epileptic patients on long-term therapy with a single anticonvulsant showed enhanced expression of peripheral benzodiazepine receptors (pBZrs) on neutrophils, monocytes and lymphocytes. N-Formyl-methionyl-leucyl-phenylalanine-induced chemotaxis was significantly impaired in neutrophils from patients on carbamazepine (p < 0.01 vs. controls). Neutrophils from patients on phenytoin had enhanced phorbol myristate acetate-stimulated O–2 production (p < 0.01 vs. controls) and neutrophils from patients on valproic acid had impaired phagocytosis frequency and Staphylococcus aureus lethality index (p < 0.01 vs. controls). Overexpression of pBZrs on leukocytes may reflect the clinical response to anticonvulsants and may play a role in the immunological effects of some of these drugs.

Published
1998

5. Effects of carbamazepine on human PMN function: possible role of peripheral benzodiazepine receptors

Author

Franca Marino, E. Caldiroli, Fabrizio De Ponti, Marco Cosentino, Anna Fietta, Sergio Lecchini, G. M. Frigo, and M. Taddei

Subjects
Adult, Lipopolysaccharides, Neutrophils, Pharmacology, In Vitro Techniques, General Biochemistry, Genetics and Molecular Biology, Text mining, History and Philosophy of Science, Phagocytosis, Candida albicans, Medicine, Humans, Benzodiazepinones, business.industry, GABAA receptor, General Neuroscience, Carbamazepine, Isoquinolines, Receptors, GABA-A, Peripheral, N-Formylmethionine Leucyl-Phenylalanine, Chemotaxis, Leukocyte, business, Function (biology), medicine.drug
Published
1998

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