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1. Mitigated cytotoxicity and tremendously enhanced gene transfection efficiency of PEI through facile one-step carbamate modification.

Author

Yang C, Cheng W, Teo PY, Engler AC, Coady DJ, Hedrick JL, and Yang YY

Subjects
Cell Survival drug effects, DNA chemistry, DNA metabolism, Dioxanes chemistry, Hep G2 Cells, Humans, Nanostructures chemistry, Nanostructures toxicity, Polyethyleneimine toxicity, Transfection, Carbamates chemistry, Polyethyleneimine chemistry
Abstract

Extremely efficacious gene transfection vector: The rapid and facile modification of PEI with commercially available TMC produces an extremely efficacious gene delivery vector with minimal cytotoxicity. Functionalization of PEI is easily controlled by PEI:cyclic carbonate feed ratios and allows for the addition of functionality. Modified PEIs hold great potential as gene delivery systems due to easy synthesis, scalability, low cost, low toxicity, and outstanding transfection capacity., (Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2013
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