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[Display omitted] A palladium-catalyzed regioselective arylation at the C6 position of 7-hydroxyflavone protocol was disclosed for the first time. The reaction occurs in carbamate directing group directed C H activation manner. The key to this high regioselectivity is the appropriate choice of carbamates as protecting/directing groups and H 3 PO 4 additive in the presence of Pd (TFA) 2 catalyst. Additionally, the procedure provided an expedient approach for the preparation of 6-arylflavone derivatives. [ABSTRACT FROM AUTHOR]