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Start Over Author "Sengul B" Topic capsaicin
2 results on '"Sengul B"'

1. Mechanism of capsaicin inhibition of aldose reductase activity.

Author

Alim Z, Kilinc N, Sengul B, and Beydemir S

Subjects
Aldehyde Reductase metabolism, Animals, Dose-Response Relationship, Drug, Male, Organ Specificity, Rats, Rats, Sprague-Dawley, Aldehyde Reductase antagonists & inhibitors, Capsaicin pharmacology, Enzyme Inhibitors pharmacology
Abstract

Aldose reductase (AR) inhibitors play a vital importance as a potential therapeutic and preventive medicine when it comes to hyperglycemia associated diabetic complications. Additionally, capsaicin is used as a food additive and a drug in a number of diverse clinical trials. The aim of this study is to determine the in vitro inhibition behavior of capsaicin on AR enzyme activity, which was obtained from different rat tissues (heart, kidney, liver, and brain). We showed that AR was inhibited by capsaicin in the micromolar range and noncompetitive manner in all of the tissues. K i values of capsaicin were found to be 8.87, 264, 535, and 597, respectively, in heart AR, kidney AR, liver AR, and brain AR. In conclusion, capsaicin may be an effective molecule when used in low concentrations to prevent diabetic complications associated with the polyol pathway., (© 2017 Wiley Periodicals, Inc.)

Published
2017
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2. Mechanism of capsaicin inhibition of aldose reductase activity

Author

Alim Z., Kilinc N., Sengul B., Beydemir S., and Bayburt University

Subjects
Male, kidney, in vitro study, brain, enzyme inhibitor, heart, liver, capsaicin, Article, animal tissue, Rats, Sprague-Dawley, Aldehyde Reductase, dose response, diabetic complications, drug mechanism, Animals, controlled study, rat, animal, Enzyme Inhibitors, enzyme inhibition, antagonists and inhibitors, nonhuman, Sprague Dawley rat, Dose-Response Relationship, Drug, antibody specificity, aldose reductase, inhibition, enzyme activity, Rats, drug efficacy, Organ Specificity, metabolism
Abstract

Aldose reductase (AR) inhibitors play a vital importance as a potential therapeutic and preventive medicine when it comes to hyperglycemia associated diabetic complications. Additionally, capsaicin is used as a food additive and a drug in a number of diverse clinical trials. The aim of this study is to determine the in vitro inhibition behavior of capsaicin on AR enzyme activity, which was obtained from different rat tissues (heart, kidney, liver, and brain). We showed that AR was inhibited by capsaicin in the micromolar range and noncompetitive manner in all of the tissues. Ki values of capsaicin were found to be 8.87, 264, 535, and 597, respectively, in heart AR, kidney AR, liver AR, and brain AR. In conclusion, capsaicin may be an effective molecule when used in low concentrations to prevent diabetic complications associated with the polyol pathway. © 2017 Wiley Periodicals, Inc.

Published
2017

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