Search

Your search keyword '"Krafft E"' showing total 3 results
Start Over Author "Krafft E" Topic canine
3 results on '"Krafft E"'

1. Pulmonary Vein‐to‐Pulmonary Artery Ratio is an Echocardiographic Index of Congestive Heart Failure in Dogs with Degenerative Mitral Valve Disease

Author

Merveille, A.‐C., Bolen, G., Krafft, E., Roels, E., Gomart, S., Etienne, A.‐L., Clercx, C., and Mc Entee, K.

Subjects
Heart Failure, Cardiology, Mitral Valve Insufficiency, Standard Article, Pulmonary Artery, Standard Articles, Canine, Dogs, Echocardiography, Pulmonary Veins, Case-Control Studies, Diagnosis, Congestion, Animals, SMALL ANIMAL, Dog Diseases, Pulmonary vein
Abstract

Background Early recognition of left‐sided congestive heart failure (CHF) in dogs with degenerative mitral valve disease (DMVD) is important because it influences medical therapy, timing of follow‐up, and outcome. Hypothesis Pulmonary vein diameter‐to‐pulmonary artery diameter ratio (PV/PA) measured by echocardiography can predict CHF. Animals Ninety‐eight client‐owned dogs, 37 controls, and 61 dogs with DMVD. Methods Prospective clinical cohort study. History, physical examination and Doppler‐echocardiography were performed. Dogs were classified as International Small Animal Cardiac Health Council class I, II or III. Congestive heart failure was identified in a subset of 56 dogs based on radiographic findings. The PV/PA was measured in bidimensional (2D) and M‐mode by 2 investigators blinded to the radiologists’ conclusions. Results Interobserver coefficients of variation for PV/PA acquisition and measurement were

Published
2015

2. Pulmonary vein to pulmonary artery ratio is an echocardiographic index of congestive heart failure in dogs with degenerative mitral valve disease

Author

Merveille, Anne-Christine, Etienne, Anne Lise A., Krafft, E, Roels, E., Gomart, Samantha, Bolen, G, Clercx, Cécile, and McEntee, Kathleen

Subjects
Physiologie générale, Diagnosis, Congestion, Pulmonary vein, Canine
Abstract

Background: Early recognition of left-sided congestive heart failure (CHF) in dogs with degenerative mitral valve disease (DMVD) is important because it influences medical therapy, timing of follow-up, and outcome. Hypothesis: Pulmonary vein diameter-to-pulmonary artery diameter ratio (PV/PA) measured by echocardiography can predict CHF. Animals: Ninety-eight client-owned dogs, 37 controls, and 61 dogs with DMVD. Methods: Prospective clinical cohort study. History, physical examination and Doppler-echocardiography were performed. Dogs were classified as International Small Animal Cardiac Health Council class I, II or III. Congestive heart failure was identified in a subset of 56 dogs based on radiographic findings. The PV/PA was measured in bidimensional (2D) and M-mode by 2 investigators blinded to the radiologists' conclusions. Results: Interobserver coefficients of variation for PV/PA acquisition and measurement were, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2015

3. Analysis of gene expression in canine idiopathic pulmonary fibrosis.

Author

Krafft, E., Laurila, H. P., Peters, I. R., Bureau, F., Peeters, D., Day, M. J., Rajamäki, M. M., and Clercx, C.

Subjects
*GENE expression, *IDIOPATHIC pulmonary fibrosis, *DOG diseases, *RARE diseases, *ETIOLOGY of diseases, *WEST Highland white terrier
Abstract

Idiopathic pulmonary fibrosis (IPF) in dogs is a rare disease of unknown aetiology, seen in terrier breeds, particularly the West Highland white terrier (WHWT). The aim of this study was to determine pulmonary gene expression in canine IPF in order to gain insights into the pathogenesis of the disease and to identify possible biomarkers. Microarray analyses were conducted to determine gene expression profiles in the lungs of dogs with IPF and control dogs of various breeds. More than 700 genes were identified as having greater than two-fold difference in expression between the two groups. The significant biological functions associated with these genes were related to cellular growth and proliferation, developmental processes, cellular movement, cell to cell signalling and interaction, and antigen presentation. Altered levels of expression were confirmed by quantitative reverse transcriptase PCR for genes encoding chemokine (C-C) ligand (CCL) 2 (+4.9 times), CCL7 (+6.8 times), interleukin 8 (+4.32 times), chemokine (C-X-C) ligand 14 (+3.4 times), fibroblast activation protein (+4.7 times) and the palate, lung and nasal associated protein (PLUNC, -25 times). Serum CCL2 concentrations were significantly higher in WHWTs with IPF (mean 628.1 pg/mL, interquartile range 460.3-652.7 pg/mL) than unaffected WHWTs (mean 344.0 pg/mL, interquartile range 254.5-415.5 pg/mL; P = 0.001 ). The results support CCL2 as a candidate biomarker for IPF in dogs. [ABSTRACT FROM AUTHOR]

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results