1. Fungal profile and antifungal susceptibility pattern of candidiasis in esophageal cancer patients.
- Author
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Talukdar A, Barman R, Sarma A, Krishnatreya M, Sharma JD, and Kataki AC
- Subjects
- Adult, Candidiasis drug therapy, Candidiasis pathology, Esophageal Neoplasms microbiology, Esophageal Neoplasms pathology, Female, Follow-Up Studies, Humans, India epidemiology, Male, Microbial Sensitivity Tests, Prognosis, Prospective Studies, Antifungal Agents pharmacology, Candida drug effects, Candidiasis complications, Drug Resistance, Fungal, Esophageal Neoplasms epidemiology
- Abstract
Aim: This study was carried out to determine the fungal profile and antifungal susceptibility pattern in the brushing samples of candidiasis in patients with carcinoma of esophagus., Materials and Methods: The study was carried out in the Departments of Microbiology and Surgical Oncology of a regional cancer center from January 2017 to December 2017. Samples were collected under all aseptic precaution and Clinical Laboratory Standards Institute guidelines 2017 was followed for antifungal susceptibility testing., Results: A total of 132 endoscopy brushing samples were collected from histological proven esophageal cancer patients and processed for fungal culture. Of which, 75 (56.81%) samples showed culture positivity and were recruited. Candida albicans in 40 (53.33%), Candida krusei in 25 (33.33%), Candida tropicalis in 7 (9.33%), and Candida glabrata in 3 (4%) patients were seen. Among the 40 C. albicans isolates, all were sensitive to caspofungin - 40 (100%), 34 (85%) showed sensitivity to fluconazole, and 32 (80%) showed sensitivity to flucytosine. C. krusei and C. tropicalis showed 100% sensitivity to caspofungin, and C. glabrata isolates showed 100% resistance to caspofungin and 80% resistance to Amphotericin B., Conclusion: The present study revealed the emergence of multidrug-resistant, nonalbicans Candida isolates in cancer esophagus patients with candidiasis in northeast India., Competing Interests: None
- Published
- 2020
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