1. Pancreatic Cancer-Associated Fibroblasts: Where Do We Go from Here?
- Author
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Carpenter ES, Vendramini-Costa DB, Hasselluhn MC, Maitra A, Olive KP, Cukierman E, Pasca di Magliano M, and Sherman MH
- Subjects
- Humans, Animals, Cancer-Associated Fibroblasts pathology, Cancer-Associated Fibroblasts metabolism, Pancreatic Neoplasms pathology, Tumor Microenvironment, Carcinoma, Pancreatic Ductal pathology
- Abstract
Pancreatic ductal adenocarcinoma is a deadly disease and is projected to become the second leading cause of cancer-related death by 2030. A major hallmark is the exuberant host response comprising the tumor microenvironment, of which, cancer-associated fibroblasts (CAF) are a prevalent component. Despite the gains in understanding of their heterogeneity and functionality from CAF studies in recent years, there are many unanswered questions surrounding this diverse population of cells. Here, we summarize the views of several experts in the field, focusing on the current understanding of CAFs and challenges to address., (©2024 American Association for Cancer Research.)
- Published
- 2024
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