1. Prognostic factors in metastatic renal cell carcinoma: metastasectomy as independent prognostic variable.
- Author
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Vogl, U. M., Zehetgruber, H., Dominkus, M., Hejna, M., Zielinski, C. C., Haitel, A., and Schmidinger, M.
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RENAL cell carcinoma , *RENAL cancer , *CANCER treatment , *CANCER patients , *IMMUNOREGULATION , *CARCINOGENESIS , *MEDICAL research - Abstract
Prognostic and predictive factors in patients with metastatic renal cell carcinoma (MRCC) have been evaluated from untreated patients or patients on several different treatment approaches. The aim of this analysis was to define prognostic and predictive factors in patients treated uniformly with a low-dose outpatient cytokine combination. The relationship between patient-, tumour-, and treatment-related factors was analysed in 99 patients with MRCC. These features were first examined in univariate analyses, then a stepwise modelling approach based on Cox regression was used to form a multivariate model. Nuclear grade, metastasectomy – even incomplete – C-reactive protein and lactate dehydrogenase were identified as independent prognostic factors for survival. Patients assigned to three different risk groups had statistically significant survival differences (30, 22 and 6 months, respectively). A total of 43.4% had undergone metastasectomy, mostly incomplete. Risk group affiliation was correlated with response to treatment. Our findings strongly suggest the consideration of metastasectomy in the management of patients with metastatic renal cell cancer undergoing either immunotherapy or targeted treatment.British Journal of Cancer (2006) 95, 691–698. doi:10.1038/sj.bjc.6603327 www.bjcancer.com Published online 29 August 2006 [ABSTRACT FROM AUTHOR]
- Published
- 2006
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