1. Hydrotalcite monolayer toward high performance synergistic dual-modal imaging and cancer therapy.
- Author
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Mei, Xuan, Wang, Wei, Yan, Liang, Hu, Tingting, Liang, Ruizheng, Yan, Dan, Wei, Min, Evans, David G., and Duan, Xue
- Subjects
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COMPANION diagnostics , *HYDROTALCITE , *SILVER nanoparticles , *MEDICAL imaging systems , *CANCER treatment - Abstract
Recently, theranostic has drawn tremendous attention by virtue of the nanotechnology development and new material exploration. Herein, we reported a novel theranostic system by loading Au nanoclusters (AuNCs) and Chlorin e6 (photosensitizer, Ce6) onto the monolayer nanosheet surface of Gd-doped layered double hydroxide (Gd-LDH). The as-prepared Ce6&AuNCs/Gd-LDH exhibits a largely enhanced fluorescence quantum yield (QY) of 18.5% relative to pristine AuNCs (QY = 3.1%) as well as superior T 1 magnetic resonance imaging (MRI) performance ( r 1 = 17.57 mM −1 s −1 ) compared with commercial MRI contrast agent (Gd(III)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (Gd-DOTA): r 1 ≈ 3.4 mM −1 s −1 ), resulting from a synergistic effect between AuNCs and Gd-LDH. In addition, both in vitro and in vivo therapeutic evaluations demonstrate an efficient dual-modality imaging guided anticancer performance, especially the synergetic enhanced magnetic resonance/fluorescence (MR/FL) visualization of tumor site. Therefore, this work demonstrates a successful paradigm for the design and preparation of LDHs monolayer-based theranostic material, which holds great promises in practical applications. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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