1. Synthesis, structure and properties of complex compounds of cobalt, nickel, copper and zinc with 2-formylpyridine semicarbazone.
- Author
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Gulya, A. P., Gynzhu, D., Bairak, N. N., Poirier, D., and Tsapkov, V. I.
- Subjects
CHEMICAL reactions ,CANCER cells ,CANCER treatment ,LEUKEMIA treatment ,DEHYDRATION - Abstract
2-Formylpyridine semicarbazone L reacts with cobalt, nickel, copper and zinc chlorides, nitrates and perchlorites to form coordination compounds of compositions ML
2 X2 · nH2 O (M=Co, Ni, Cu, Zn; X = Cl, NO3 , ClO4 ; L = NC5 H4 -CH=N-NH-C(O)-NH2 ; n = 0, 1) and CuLX2 · nH2 O (X = Cl, Br, NO3 ; n = 0−0.5). Complex CuL(NO3 )2 has polynuclear, CuLX2 ·0.5H2 O (X = Cl, Br), binuclear, and other compounds, mononuclear structures. Azomethine L behaves in them as tridental N,N,O-ligand. Thermolysis of these complexes proceeds through such stages as dehydration (80–95°C), deactivation (145–155°C) and complete theral degradation (170–590°C). Complexes CuLX2 · nH2 O (X = Cl, NO3 ; n = 0−0.5) were established to inhibit in vitro the growth and reproduction of 100% of cancer cells of human mieloid leukaemia HL-60 at 10−4 M concentration. At 10−5 M concentration they inhibit only 10% of cells, and at 10−6 M concentration they do not possess anticancer activity. [ABSTRACT FROM AUTHOR]- Published
- 2009
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