1. Hsa_circ_0075341 is up-regulated and exerts oncogenic properties by sponging miR-149-5p in cervical cancer
- Author
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Yongyan Zhang, Shelian Wang, Shiqing Shao, Chen Wang, and Hongxia Zhang
- Subjects
0301 basic medicine ,Uterine Cervical Neoplasms ,RM1-950 ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Downregulation and upregulation ,Cell Line, Tumor ,Cervical carcinoma ,medicine ,Humans ,Neoplasm Invasiveness ,hsa_circ_0075341 ,Cell Proliferation ,Neoplasm Staging ,Pharmacology ,Cervical cancer ,AURKA ,Tumor size ,business.industry ,General Medicine ,RNA, Circular ,medicine.disease ,miR-149-5p ,In vitro ,Up-Regulation ,MicroRNAs ,030104 developmental biology ,Tumor progression ,030220 oncology & carcinogenesis ,Lymphatic Metastasis ,Cancer research ,Disease Progression ,Female ,Therapeutics. Pharmacology ,business - Abstract
Increasing evidence revealed that circular RNAs (circRNAs) play important roles in tumor progression. In the present study, we explored the roles and underlying mechanisms of hsa_circ_0075341 in cervical cancer development. Our data showed that the expression of hsa_circ_0075341 was significantly upregulated and associated with larger tumor size, advanced FIGO stage, and lymph-node metastasis in cervical cancer patients. Hsa_circ_0075341 inhibition reduced cervical cancer cell proliferation and invasion in vitro. In mechanism, hsa_circ_0075341 negatively regulated miR-149-5p in cervical cancer progression. In addition, AURKA was confirmed as a direct target of miR-149-5p in cervical cancer and positively regulated by hsa_circ_0075341. Collectively, our data suggested that hsa_circ_0075341 promoted cervical cancer cell proliferation and invasion through regulating the miR-149-5p/AURKA axis, which provided a novel therapeutic target for cervical cancer treatment.
- Published
- 2020