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Your search keyword '"Maria Clara Borges de Andrade"' showing total 2 results
Start Over Author "Maria Clara Borges de Andrade" Topic cancer research
2 results on '"Maria Clara Borges de Andrade"'

1. Patient-centered outcomes in non-small-cell lung cancer: a real-world perspective

Author

Pedro Nazareth Aguiar, Perla de Mello Andrade, Mauro Zukin, Clarissa Baldotto, Natalia Carvalho, Debora Victorino de Azevedo, Maria Clara Borges de Andrade, Raphaela Lima, Nelson Teich, Mayara Batista, Luiz H. Araujo, Cecilia Lameirinhas Longo, and Mariana Ribeiro Monteiro

Subjects
Adult, Male, Cancer Research, medicine.medical_specialty, Lung Neoplasms, Adolescent, Kaplan-Meier Estimate, Emotional functioning, Young Adult, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Cost of Illness, Quality of life, Risk Factors, Carcinoma, Non-Small-Cell Lung, Surveys and Questionnaires, Internal medicine, medicine, Humans, Patient Reported Outcome Measures, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, Lung cancer, Fatigue, Survival analysis, Aged, business.industry, Patient-centered outcomes, Cancer, Cancer Pain, General Medicine, Middle Aged, medicine.disease, Oncology, 030220 oncology & carcinogenesis, Quality of Life, Female, Non small cell, business, Brazil
Abstract

Aims: To assess non-small-cell lung cancer (NSCLC) patient-centered outcomes in the real world. Methods: This is a prospective study of NSCLC patients treated at a private cancer care institution in Brazil between 2014 and 2019. Results: The report comprises 337 patients. Advanced stage was associated with higher symptom burden – fatigue (p = 0.03), pain (p

Published
2021

2. Cancer patients diagnosed with COVID-19 infection: A multicenter retrospective cohort of nine Brazilian cancer centers

Author

Gustavo Henrique Munhoz Piotto, Camila Brambilla Souza, Daniela Pezzutti, Cecilia Lameirinhas Longo, Mariana Ribeiro Monteiro, Maria Clara Borges de Andrade, Cynthia Lemos Ferreira, Sueli Monterroso da Cruz, Tercia Tarciane Soares de Sousa, Maria Carolina Lopes Perdigao, Luiz H. Araujo, Angelo Maiolino, Kaique Ferreira Costa de Almeida, Ana Beatriz Kinupe Abrahao, Tiago Costa de Padua, F. M. Vieira, Rafael Luis Moura Lima do Carmo, and Tuane Borges do Livramento Freitas

Subjects
Cancer Research, medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Cancer, Retrospective cohort study, medicine.disease, Oncology, Internal medicine, Pandemic, Medicine, business
Abstract

e13600 Background: The COVID-19 infection was declared pandemic in March 2020. Since then, multiple studies have attempted to correlate clinical factors with risk of complications from COVID-19, including cancer. However, cancer patients are underrepresented in clinical trials and the results vary between different cohorts. Methods: We conducted a multicentre retrospective study, based on systematic review of medical records, including nine cancer centers, located in five different Brazilian cities. Patients were diagnosed with COVID-19 through RT-PCR between March 15, 2020 and August 13 , 2020. Poisson regression models were then used to test for an association between clinical characteristics and severity of COVID-19 infections. Results: 102 patients had data collected for analysis, 85 (83.3%) of whom were hospitalized due to complications from COVID-19 infection. The median age was 65.8 years, most were female patients (61.8%) and white (73,5%). 78.4% had a performance status of 0-1, and the most common cancer subtypes were gastrointestinal (30.4%), breast (22.6%) and hematological (13.7%). Almost 40% of population had stage IV disease. Mortality rate for all hospitalized patients was 36.5%, while for those admitted to the ICU it was 68.4%. Key univariable risk factors for mortality included age (RR 1.03), ECOG ≥ 2 (RR 1.83), hypertension (RR 1.72), lung metastasis (RR 1.67), and lymphocytes ≤ 1000 admission (RR 2.40). At the multivariable analysis, the risk factors were also age (RR 1.02), primary lung cancer (RR 2.61), lung metastasis (RR 2.86), and coronary disease (RR 3.76). Conclusions: Despite the high mortality of patients hospitalized with COVID-19, our data are compatible with other cohorts. Cancer patients must be carefully monitored in pandemic periods of infectious diseases.

Published
2021

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