1. Radiotherapy for Melanoma with Perineural Invasion: University of Florida Experience.
- Author
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Zhu, Simeng and Mendenhall, William M.
- Subjects
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CLINICAL trials , *MELANOMA treatment , *ADJUVANT treatment of cancer , *RADIOTHERAPY , *METASTASIS , *CANCER relapse , *CANCER invasiveness , *MELANOMA , *PERIPHERAL nervous system , *PROGNOSIS , *SKIN tumors , *TIME , *UNIVERSITIES & colleges , *TREATMENT effectiveness , *RETROSPECTIVE studies , *DISEASE progression - Abstract
Purpose: Outcomes after adjuvant radiotherapy for cutaneous melanoma with perineural invasion (PNI).Methods: Seven patients (5 cutaneous, 2 recurrent nerve lesions) received radiotherapy.Results: At a median 4.5 years: Two patients did not recur; no local failures occurred. Three patients who omitted nodal irradiation developed regional failures (2 out-of-field, 1 in-field). Three patients developed distant metastases. Four died with disease (median, 3.6 years); 1 died from intercurrent disease (13.0 years). Two are alive without disease (6.8 and 11.6 years). No patient experienced grade ≥3 toxicity.Conclusions: Postoperative radiotherapy can reduce local recurrences; primary radiotherapy for unresectable disease is recommended. [ABSTRACT FROM AUTHOR]- Published
- 2018
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