1. Precision oncology for children: A primer for paediatricians.
- Author
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Cohen-Gogo, Sarah, Denburg, Avram E, Villani, Anita, Thacker, Nirav, Egan, Grace, Rafael, Margarida Simao, Malkin, David, and Morgenstern, Daniel A
- Subjects
DIAGNOSIS of tumors in children ,SEQUENCE analysis ,ACCURACY ,TUMORS in children ,SURVIVAL rate ,GENOMICS ,GENE expression profiling ,DISEASE susceptibility ,INTEGRATED health care delivery ,CANCER patient medical care ,ONCOLOGY ,CHILDREN - Abstract
Cancer is the leading cause of disease-related death in children, adolescents, and young adults beyond the newborn period in North America. Improving survival rates for patients with hard-to-cure cancer remains a challenge. One approach that has gained particular traction is 'precision oncology', whereby next-generation sequencing is used to identify genomic or transcriptomic changes that can help clarify the diagnosis, refine prognosis, define an underlying genetic cause, or identify a unique treatment target for a patient's cancer. In this primer, we provide a brief overview of the evolution of precision paediatric oncology, its current application to clinical oncology practice, and its future potential as a foundational approach to paediatric oncology care in Canada and around the world. We also address the many challenges and limitations inherent to the implementation of precision oncology as the standard of care, including ethical and economic considerations. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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