1. MiR-203 suppresses tumor growth and invasion and down-regulates MiR-21 expression through repressing Ran in esophageal cancer.
- Author
-
Zhang, Fang, Yang, Zhiping, Cao, Minjun, Xu, Yinsheng, Li, Jintao, Chen, Xuebin, Gao, Zhi, Xin, Jing, Zhou, Shaomei, Zhou, Zhixiang, Yang, Yishu, Sheng, Wang, and Zeng, Yi
- Subjects
- *
TUMOR growth , *CANCER invasiveness , *ESOPHAGEAL cancer , *GENE expression , *MICRORNA , *CANCER cell migration , *CANCER cell proliferation , *GENETICS - Abstract
Abstract: The expression of miR-203 has been reported to be significantly down-regulated in esophageal cancer. We showed here that overexpression of miR-203 in esophageal cancer cells dramatically increased cell apoptosis and inhibited cell proliferation, migration and invasion as well as tumor growth and down-regulated miR-21 expression. We subsequently identified that small GTPase Ran was a target gene of miR-203. Furthermore, Ran restoration partially counteracted the tumor suppressive effects of miR-203 and increased miR-21 expression. Taken together, our findings suggest that miR-203 may act as novel tumor suppressor in esophageal cancer through down-regulating the expression of Ran and miR-21. [Copyright &y& Elsevier]
- Published
- 2014
- Full Text
- View/download PDF