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1. Selective Targeting of Tumor and Stromal Cells By a Nanocarrier System Displaying Lipidated Cathepsin B Inhibitor.

Author

Mikhaylov, G., Klimpel, D., Schaschke, N., Mikac, U., Vizovisek, M., Fonovic, M., Turk, V., Turk, Boris, and Vasiljeva, Olga

Subjects
*STROMAL cells, *TUMORS, *NANOCARRIERS, *CATHEPSIN B, *CANCER invasiveness, *CANCER treatment, *TARGETED drug delivery
Abstract

Cathepsin B (CtsB) is a lysosomal cysteine proteinase that is specifically translocated to the extracellular milieu during cancer progression. The development of a lipidated CtsB inhibitor incorporated into the envelope of a liposomal nanocarrier (LNC-NS-629) is described. Ex vivo and in vivo studies confirmed selective targeting and internalization of LNC-NS-629 by tumor and stromal cells, thus validating CtsB targeting as a highly promising approach to cancer diagnosis and treatment. [ABSTRACT FROM AUTHOR]

Published
2014
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