1. 2D Monoelemental Germanene Quantum Dots: Synthesis as Robust Photothermal Agents for Photonic Cancer Nanomedicine.
- Author
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Ouyang, Jiang, Feng, Chan, Ji, Xiaoyuan, Li, Li, Gutti, Hemanth Kiran, Kim, Na Yoon, Artzi, Dolev, Xie, Angel, Kong, Na, Liu, You‐Nian, Tearney, Guillermo J., Sui, Xinbing, Tao, Wei, and Farokhzad, Omid C.
- Subjects
NANOMEDICINE ,QUANTUM dot synthesis ,PHOTOTHERMAL conversion ,QUANTUM dots ,LIQUID phase epitaxy ,CANCER - Abstract
As a new family member of the emerging two‐dimensional (2D) monoelemental materials (Xenes), germanene has shown promising advantages over the prototypical 2D Xenes, such as black phosphorus (BP) and graphene. However, efficient manufacture of novel germanene nanostructures is still a challenge. Herein, a simple top‐down approach for the liquid‐exfoliation of ultra‐small germanene quantum dots (GeQDs) is presented. The prepared GeQDs possess an average lateral size of about 4.5 nm and thickness of about 2.2 nm. The functionalized GeQDs were demonstrated to be robust photothermal agents (PTAs) with outstanding photothermal conversion efficacy (higher than those of graphene and BPQDs), superior stability, and excellent biocompatibility. As a proof‐of‐principle, 2D GeQDs‐based PTAs were used in fluorescence/photoacoustic/photothermal‐imaging‐guided hyperpyrexia ablation of tumors. This work could expand the application of 2D germanene to the field of photonic cancer nanomedicine. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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