34 results on '"Verdonck-de Leeuw, Irma M"'
Search Results
2. Web-based self-help intervention for partners of cancer patients based on acceptance and commitment therapy and self-compassion training: a randomized controlled trial with automated versus personal feedback
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Köhle, Nadine, Drossaert, Constance H. C., ten Klooster, Peter M., Schreurs, Karlein M. G., Hagedoorn, Mariët, Van Uden-Kraan, Cornelia F., Verdonck-de Leeuw, Irma M., and Bohlmeijer, Ernst T.
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- 2021
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3. A randomized controlled trial on the efficacy of life review therapy targeting incurably ill cancer patients: do their informal caregivers benefit?
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Kleijn, Gitta, Lissenberg-Witte, Birgit I., Bohlmeijer, Ernst T., Willemsen, Vincent, Becker-Commissaris, Annemarie, Eeltink, Corien M., Bruynzeel, Anna M.E., van der Vorst, Maurice J., Cuijpers, Pim, and Verdonck-de Leeuw, Irma M.
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- 2021
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4. Physical activity in patients with cancer: self-report versus accelerometer assessments
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Douma, Joeri A.J., de Beaufort, Maaike B., Kampshoff, Caroline S., Persoon, Saskia, Vermaire, Jorine A., Chinapaw, Mai J., van Mechelen, Willem, Nollet, Frans, Kersten, Marie José, Smit, Jan H., Verdonck-de Leeuw, Irma M., Altenburg, Teatske M., and Buffart, Laurien M.
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- 2020
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5. Patients’ experiences of life review therapy combined with memory specificity training (LRT-MST) targeting cancer patients in palliative care
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Kleijn, Gitta, van Uden-Kraan, Cornelia F., Bohlmeijer, Ernst T., Becker-Commissaris, Annemarie, Pronk, Mathilde, Willemsen, Vincent, Cuijpers, Pim, and Verdonck-de Leeuw, Irma M.
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- 2019
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6. A systematic review of the measurement properties of the Body Image Scale (BIS) in cancer patients
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Melissant, Heleen C., Neijenhuijs, Koen I., Jansen, Femke, Aaronson, Neil K., Groenvold, Mogens, Holzner, Bernhard, Terwee, Caroline B., van Uden-Kraan, Cornelia F., Cuijpers, Pim, and Verdonck-de Leeuw, Irma M.
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- 2018
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7. Moderators of the effects of meaning-centered group psychotherapy in cancer survivors on personal meaning, psychological well-being, and distress
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Holtmaat, Karen, van der Spek, Nadia, Witte, Birgit I., Breitbart, William, Cuijpers, Pim, and Verdonck-de Leeuw, Irma M.
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- 2017
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8. A guided self-help intervention targeting psychological distress among head and neck cancer and lung cancer patients: motivation to start, experiences and perceived outcomes
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Krebber, Anne-Marie H, van Uden-Kraan, Cornelia F, Melissant, Heleen C, Cuijpers, Pim, van Straten, Annemieke, Becker-Commissaris, Annemarie, Leemans, C René, and Verdonck-de Leeuw, Irma M
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- 2017
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9. The impact of cancer on psychosocial function and quality of life: A cross‐sectional study in 18 pan‐European countries.
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Bazilainsky, Svetlana, Cohen, Miri, Holtmaat, Karen, Erlich, Brach, and Verdonck‐de Leeuw, Irma M.
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PSYCHOSOCIAL functioning ,QUALITY of life ,PSYCHO-oncology ,LONELINESS ,CROSS-sectional method ,GROSS domestic product ,CANCER survivors - Abstract
Background: To improve psychosocial cancer care in Europe, more information is needed on psychosocial function and quality of life (QoL) among cancer patients in European countries. Aims: To investigate differences in psychosocial function between cancer survivors and the general population in Europe, in relation to national economic status and personal factors. Method: Data were from the Survey of Health, Aging and Retirement in Europe (Wave 6). Main outcomes were psychosocial functioning: activity limitations, income adequacy, loneliness, depression, and QoL. Factors possibly associated with the main outcomes were ever having cancer, gross domestic product (GDP), and personal factors (age, gender, education, marriage status, employment status, number of children, number of chronic diseases). Results: The study sample featured 6238 cancer survivors and 60,961 individuals without cancer aged 50 or older in 17 European countries and Israel. Levels of depression were higher and QoL was lower among cancer survivors compared to individuals without cancer and worse in low GDP countries, whereas differences in income adequacy and loneliness were not statistically significant. The interaction of cancer groups and country groups indicated a significant interactional effect on activity limitations, loneliness, depression, and QoL. In a multivariate regression analysis, personal factors, GDP, and being a cancer survivor predicted the main outcome variables. Conclusions: Cancer has a persistent negative effect on survivors that is related to a country's GDP. Cancer survivors in low‐GDP countries are affected by the consequences of cancer intertwined with the hardships of living in a low‐GDP country. [ABSTRACT FROM AUTHOR]
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- 2023
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10. Moderators of the effects of group-based physical exercise on cancer survivors’ quality of life
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Kalter, Joeri, Buffart, Laurien M., Korstjens, Irene, van Weert, Ellen, Brug, Johannes, Verdonck-de Leeuw, Irma M., Mesters, Ilse, van den Borne, Bart, Hoekstra-Weebers, Josette E. H. M., Ros, Wynand J. G., and May, Anne M.
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- 2015
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11. Detection and localization of early- and late-stage cancers using platelet RNA
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In ’t Veld, Sjors G.J.G., Arkani, Mohammad, Post, Edward, Antunes-Ferreira, Mafalda, D'Ambrosi, Silvia, Vessies, Daan C.L., Vermunt, Lisa, Vancura, Adrienne, Muller, Mirte, Niemeijer, Anna Larissa N., Tannous, Jihane, Meijer, Laura L., Le Large, Tessa Y.S., Mantini, Giulia, Wondergem, Niels E., Heinhuis, Kimberley M., van Wilpe, Sandra, Smits, A. Josien, Drees, Esther E.E., Roos, Eva, Leurs, Cyra E., Tjon Kon Fat, Lee Ann, van der Lelij, Ewoud J., Dwarshuis, Govert, Kamphuis, Maarten J., Visser, Lisanne E., Harting, Romee, Gregory, Annemijn, Schweiger, Markus W., Wedekind, Laurine E., Ramaker, Jip, Zwaan, Kenn, Verschueren, Heleen, Bahce, Idris, de Langen, Adrianus J., Smit, Egbert F., van den Heuvel, Michel M., Hartemink, Koen J., Kuijpers, Marijke J.E., oude Egbrink, Mirjam G.A., Griffioen, Arjan W., Rossel, Rafael, Hiltermann, T. Jeroen N., Lee-Lewandrowski, Elizabeth, Lewandrowski, Kent B., De Witt Hamer, Philip C., Kouwenhoven, Mathilde, Reijneveld, Jaap C., Leenders, William P.J., Hoeben, Ann, Verdonck-de Leeuw, Irma M., Leemans, C. René, Baatenburg de Jong, Robert J., Terhaard, Chris H.J., Takes, Robert P., Langendijk, Johannes A., de Jager, Saskia C., Kraaijeveld, Adriaan O., Pasterkamp, Gerard, Smits, Minke, Schalken, Jack A., Łapińska-Szumczyk, Sylwia, Łojkowska, Anna, Żaczek, Anna J., Lokhorst, Henk, van de Donk, Niels W.C.J., Nijhof, Inger, Prins, Henk Jan, Zijlstra, Josée M., Idema, Sander, Baayen, Johannes C., Teunissen, Charlotte E., Killestein, Joep, Besselink, Marc G., Brammen, Lindsay, Bachleitner-Hofmann, Thomas, Mateen, Farrah, Plukker, John T.M., Heger, Michal, de Mast, Quirijn, Lisman, Ton, Pegtel, D. Michiel, Bogaard, Harm Jan, Jassem, Jacek, Supernat, Anna, Mehra, Niven, Gerritsen, Winald, de Kroon, Cornelis D., Lok, Christianne A.R., Piek, Jurgen M.J., Steeghs, Neeltje, van Houdt, Winan J., Brakenhoff, Ruud H., Sonke, Gabe S., Verheul, Henk M., Giovannetti, Elisa, Kazemier, Geert, Sabrkhany, Siamack, Schuuring, Ed, Sistermans, Erik A., Wolthuis, Rob, Meijers-Heijboer, Hanne, Dorsman, Josephine, Oudejans, Cees, Ylstra, Bauke, Westerman, Bart A., van den Broek, Daan, Koppers-Lalic, Danijela, Wesseling, Pieter, Nilsson, R. Jonas A., Vandertop, W. Peter, Noske, David P., Tannous, Bakhos A., Sol, Nik, Best, Myron G., Wurdinger, Thomas, Pharmaceutics, Sub Membrane Biochemistry & Biophysics, Afd Pharmaceutics, CCA - Imaging and biomarkers, CCA - Cancer Treatment and Quality of Life, CCA - Cancer biology and immunology, AII - Cancer immunology, Amsterdam Gastroenterology Endocrinology Metabolism, Graduate School, Pulmonology, Neurosurgery, Surgery, Obstetrics and Gynaecology, Oncogenomics, Amsterdam Neuroscience - Neurovascular Disorders, Amsterdam Neuroscience - Systems & Network Neuroscience, Biochemie, MUMC+: HVC Pieken Trombose (9), RS: Carim - B03 Cell biochemistry of thrombosis and haemostasis, Fysiologie, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, MUMC+: MA Medische Oncologie (9), Pathology, Otorhinolaryngology and Head and Neck Surgery, Pulmonary medicine, Laboratory Medicine, Amsterdam Neuroscience - Neurodegeneration, Medical oncology laboratory, Otolaryngology / Head & Neck Surgery, Urology, Neurology, Intensive care medicine, APH - Mental Health, APH - Personalized Medicine, Radiation Oncology, Hematology, Hematology laboratory, Amsterdam Neuroscience - Neuroinfection & -inflammation, ACS - Pulmonary hypertension & thrombosis, Internal medicine, Obstetrics and gynaecology, Human genetics, Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Reproduction & Development (AR&D), ACS - Atherosclerosis & ischemic syndromes, Translational Immunology Groningen (TRIGR), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Groningen Institute for Organ Transplantation (GIOT), Targeted Gynaecologic Oncology (TARGON), Pharmaceutics, Sub Membrane Biochemistry & Biophysics, and Afd Pharmaceutics
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Cancer och onkologi ,Cancer Research ,liquid biopsy ,Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2] ,blood platelets ,Rare cancers Radboud Institute for Molecular Life Sciences [Radboudumc 9] ,Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] ,lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] ,TEP ,SDG 3 - Good Health and Well-being ,Oncology ,blood ,Cancer and Oncology ,Neoplasms ,Urological cancers Radboud Institute for Health Sciences [Radboudumc 15] ,Urological cancers Radboud Institute for Molecular Life Sciences [Radboudumc 15] ,Biomarkers, Tumor ,Humans ,cancer ,RNA ,early detection ,Nanomedicine Radboud Institute for Molecular Life Sciences [Radboudumc 19] ,Early Detection of Cancer ,Rare cancers Radboud Institute for Health Sciences [Radboudumc 9] - Abstract
Contains fulltext : 281792.pdf (Publisher’s version ) (Open Access) Cancer patients benefit from early tumor detection since treatment outcomes are more favorable for less advanced cancers. Platelets are involved in cancer progression and are considered a promising biosource for cancer detection, as they alter their RNA content upon local and systemic cues. We show that tumor-educated platelet (TEP) RNA-based blood tests enable the detection of 18 cancer types. With 99% specificity in asymptomatic controls, thromboSeq correctly detected the presence of cancer in two-thirds of 1,096 blood samples from stage I-IV cancer patients and in half of 352 stage I-III tumors. Symptomatic controls, including inflammatory and cardiovascular diseases, and benign tumors had increased false-positive test results with an average specificity of 78%. Moreover, thromboSeq determined the tumor site of origin in five different tumor types correctly in over 80% of the cancer patients. These results highlight the potential properties of TEP-derived RNA panels to supplement current approaches for blood-based cancer screening.
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- 2022
12. Swallowing dysfunction in cancer patients
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Raber-Durlacher, Judith E., Brennan, Mike T., Verdonck-de Leeuw, Irma M., Gibson, Rachel J., Eilers, June G., Waltimo, Tuomas, Bots, Casper P., Michelet, Marisol, Sollecito, Thomas P., Rouleau, Tanya S., Sewnaik, Aniel, Bensadoun, Rene-Jean, Fliedner, Monica C., Silverman, Jr, Sol, Spijkervet, Fred K. L., and Dysphagia Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO)
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- 2012
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13. Symptom monitoring in cancer and fully automated advice on supportive care: Patients' perspectives on self‐management strategies and the eHealth self‐management application Oncokompas.
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Schuit, Anouk S., van Zwieten, Valesca, Holtmaat, Karen, Cuijpers, Pim, Eerenstein, Simone E. J., Leemans, C. René, Vergeer, Marije R., Voortman, Jens, Karagozoglu, Hakki, van Weert, Stijn, Korte, Mira, Frambach, Ruud, Fleuren, Margot, Hendrickx, Jan‐Jaap, and Verdonck‐de Leeuw, Irma M.
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HEAD tumors ,SELF-management (Psychology) ,MOBILE apps ,RESEARCH methodology ,INTERVIEWING ,PATIENTS' attitudes ,EXPERIENCE ,PATIENT monitoring ,QUALITATIVE research ,CANCER patients ,ATTITUDES toward illness ,QUESTIONNAIRES ,QUALITY of life ,DESCRIPTIVE statistics ,RESEARCH funding ,PSYCHOLOGICAL adaptation ,THEMATIC analysis ,DATA analysis software ,NECK tumors ,TELEMEDICINE ,COGNITIVE therapy ,COVID-19 pandemic ,SYMPTOMS - Abstract
Objective: The web‐based application Oncokompas was developed to support cancer patients to self‐manage their symptoms. This qualitative study was conducted to obtain insight in patients' self‐management strategies to cope with cancer and their experiences with Oncokompas as a fully automated behavioural intervention technology. Methods: Data were collected from semi‐structured interviews with 22 participants (10 head and neck cancer survivors and 12 incurably ill patients). Interview questions were about self‐management strategies and experiences with Oncokompas. Interviews were audio‐recorded, transcribed verbatim and analysed using thematic analysis. Results: Participants applied several self‐management strategies, among which trying to stay in control and make the best of their situation. They described Oncokompas' added value: being able to monitor symptoms and having access to a personal online library. Main reasons for not using Oncokompas were concentration problems, lack of time or having technical issues. Recommendations were made for further development of Oncokompas, relating to its content, technical and functional aspects. Conclusions: Survivors and incurably ill patients use various self‐management strategies to cope with cancer. The objectives of self‐management interventions as Oncokompas correspond well with these strategies: taking a certain responsibility for your well‐being and being in charge of your life as long as possible by obtaining automated information (24/7) on symptoms and tailored supportive care options. [ABSTRACT FROM AUTHOR]
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- 2021
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14. Psychological problems among cancer patients in relation to healthcare and societal costs: A systematic review.
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Van Beek, Florie E., Wijnhoven, Lonneke M. A., Holtmaat, Karen, Custers, José A. E., Prins, Judith B., Verdonck‐de Leeuw, Irma M., and Jansen, Femke
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ADJUSTMENT disorders ,JOB absenteeism ,CANCER patients ,MENTAL illness ,PATIENT-family relations ,DRUGS - Abstract
Objective: This study systematically reviewed the association of psychological problems among cancer patients with healthcare and societal resource use and costs. Methods: PubMed, PsycINFO, and Embase were searched (until 31 January 2021) for studies on psychological symptoms (anxiety, depression, distress, fear of recurrence) or psychiatric disorders (anxiety, depression, adjustment) and healthcare use (e.g., mental, inpatient healthcare), economic losses by patients and family, economic losses in other sectors (e.g., absence from work), and costs. The search, data extraction, and quality assessment were performed by two authors. Results: Of the 4157 identified records, 49 articles were included (psychological symptoms (n = 34), psychiatric disorders (n = 14), both (n = 1)) which focused on healthcare use (n = 36), economic losses by patients and family (n = 5), economic losses in other sectors (n = 8) and/or costs (n = 13). In total, for 12 of the 94 associations strong evidence was found. Psychological symptoms and psychiatric disorders were positively associated with increased healthcare use (mental, primary, inpatient, outpatient healthcare), losses in other sectors (absence from work), and costs (inpatient, outpatient, total healthcare costs). Moderate evidence was found for a positive association between (any) psychiatric disorder and depression disorder with inpatient healthcare and medication use, respectively. Conclusions: Psychological problems in cancer patients are associated with increased healthcare use, healthcare costs and economic losses. Further research is needed on psychological problems in relation to understudied healthcare use or costs categories, productivity losses, and informal care costs. [ABSTRACT FROM AUTHOR]
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- 2021
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15. Dutch utility weights for the EORTC cancer-specific utility instrument: the Dutch EORTC QLU-C10D.
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Jansen, Femke, Verdonck-de Leeuw, Irma M., Gamper, Eva, Norman, Richard, Holzner, Bernhard, King, Madeleine, and Kemmler, Georg
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QUALITY of life , *APPETITE loss , *PHYSICAL mobility , *GENDER , *CANCER treatment , *APPETITE - Abstract
Purpose: To measure utilities among cancer patients, a cancer-specific utility instrument called the European Organization for Research and Treatment of Cancer (EORTC) QLU-C10D has been developed based on EORTC quality of life core module (QLQ-C30). This study aimed to provide Dutch utility weights for the QLU-C10D. Methods: A cross-sectional valuation study was performed in 1017 participants representative in age and gender of the Dutch general population. The valuation method was a discrete choice experiment containing 960 choice sets, i.e. pairs of QLU-C10D health states, each health state described in terms of the 10 QLU-C10D domains and the duration of that health state. Each participant considered 16 choice sets, choosing their preferred health state from each pair. Utility scores were derived using generalized estimation equation models. Non-monotonic levels were combined. Results: Utility decrements were generated for all 10 QLU-C10D domains, with largest decrements for pain (− 0.242), physical functioning (− 0.228), and role functioning (− 0.149). Non-monotonic levels of emotional functioning, pain, fatigue, sleep problems, and appetite loss were combined. No decrement in utility was seen in case of a little or quite a bit impairment in emotional functioning or a little pain. The mean QLU-C10D utility score of the participants was 0.85 (median = 0.91, interquartile range = 0.82 to 0.96). Conclusion: Dutch utility decrements were generated for the QLU-C10D. These are important for evaluating the cost-utility of new cancer treatments and supportive care interventions. Further insight is warranted into the added value of the QLU-C10D alongside other utility instruments. [ABSTRACT FROM AUTHOR]
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- 2021
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16. Development and Psychometric Evaluation of an Item Bank for Computerized Adaptive Testing of the EORTC Insomnia Dimension in Cancer Patients (EORTC CAT-SL).
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Dirven, Linda, Petersen, Morten Aa., Aaronson, Neil K., Chie, Wei-Chu, Conroy, Thierry, Costantini, Anna, Hammerlid, Eva, Velikova, Galina, Verdonck-de Leeuw, Irma M., Young, Teresa, and Groenvold, Mogens
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To further advance assessment of patient-reported outcomes, the European Organisation of Research and Treatment of Cancer (EORTC) Quality of Life Group has developed computerized adaptive test (CAT) versions of all EORTC Quality of Life Core Questionnaire (QLQ-C30) scales/items. The aim of this study was to develop and evaluate an item bank for CAT measurement of insomnia (CAT-SL). In line with the EORTC guidelines, the developmental process comprised four phases: (I) defining the concept insomnia and literature search, (II) selection and formulation of new items, (III) pre-testing and (IV) field-testing, including psychometric analyses of the final item bank. In phase I, the literature search identified 155 items that were compatible with our conceptualisation of insomnia, including both quantity and quality of sleep. In phase II, following a multistep-approach, this number was reduced to 15 candidate items. Pre-testing of these items in cancer patients (phase III) resulted in an item list of 14 items, which were field-tested among 1094 patients in phase IV. Psychometric evaluations showed that eight items could be retained in a unidimensional model. The final item bank yielded greater measurement precision than the original QLQ-C30 insomnia item. It was estimated that administering two or more items from the insomnia item bank with CAT results in a saving in sample size between approximately 15–25%. The 8-item EORTC CAT-SL item bank facilitates precise and efficient measurement of insomnia as part of the EORTC CAT system of health-related quality life assessment in both clinical research and practice. [ABSTRACT FROM AUTHOR]
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- 2021
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17. The effectiveness of distance‐based interventions for smoking cessation and alcohol moderation among cancer survivors: A meta‐analysis.
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Mujcic, Ajla, Blankers, Matthijs, Bommelé, Jeroen, Boon, Brigitte, Berman, Anne H., Verdonck‐de Leeuw, Irma M., Laar, Margriet, and Engels, Rutger
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SMOKING cessation ,CANCER patients ,ALCOHOL drinking ,MODERATION ,SMOKING statistics - Abstract
Objective The objective of this study is to evaluate current evidence for the effectiveness of distance‐based interventions to support smoking cessation (SC) or alcohol moderation (AM) among cancer survivors. Secondary, differences in effectiveness are explored regarding multibehaviour interventions versus single‐behaviour interventions targeting SC or AM only. Methods: A systematic search of PubMed, PsycINFO, Web of Science, EMBASE, CINAHL, and Cochrane Central Register of Controlled Trials was conducted. Intervention studies with and without control groups and randomized controlled trials were included. Random effects meta‐analyses were conducted for the main outcomes: SC and AM rates at the follow‐up closest to 6 months. Using subgroup analyses and meta‐regression, effectiveness of single‐behaviour versus multibehaviour interventions was evaluated. Results: A total of 17 studies with 3796 participants; nine studies on SC only, eight studies on multibehaviour interventions including an SC or AM module, and no studies on AM only were included. All studies had at least some concerns regarding bias. Distance‐based SC interventions led to higher cessation rates than control conditions (10 studies, odds ratio [OR] = 1.56; 95% CI, 1.13‐2.15, P =.007). Single‐behaviour SC interventions reduced smoking rates compared with baseline (risk difference [RD] = 0.29; 95% CI, 0.19‐0.39, P <.0001), but multibehaviour interventions did not (RD = 0.13; 95% CI, −0.05 to 0.31, P = 0.15). There was insufficient evidence that distance‐based multibehaviour interventions reduced alcohol use compared with controls (three studies, standardized mean difference [SMD] = 0.12; 95% CI, −0.08 to 0.31, P =.24). Conclusions: Distance‐based SC interventions are effective in supporting SC among cancer survivors. Single‐behaviour SC interventions appear more effective than multibehaviour interventions. No evidence was found for the effectiveness of distance‐based AM interventions for cancer survivors. [ABSTRACT FROM AUTHOR]
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- 2020
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18. Depressive symptoms in relation to overall survival in people with head and neck cancer: A longitudinal cohort study.
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Jansen, Femke, Verdonck‐de Leeuw, Irma M., Cuijpers, Pim, Leemans, C. René, Waterboer, Tim, Pawlita, Michael, Penfold, Chris, Thomas, Steven J., Waylen, Andrea, Ness, Andrew R., and Verdonck-de Leeuw, Irma M
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MENTAL depression , *HEAD & neck cancer patients , *HEAD & neck cancer treatment , *HEAD & neck cancer diagnosis , *ANXIETY - Abstract
Objective: The objective of the study is to investigate the relation between pretreatment depressive symptoms (DS) and the course of DS during the first year after cancer diagnosis, and overall survival among people with head and neck cancer (HNC).Methods: Data from the Head and Neck 5000 prospective clinical cohort study were used. Depressive symptoms were measured using the Hospital Anxiety and Depression Scale (HADS) pretreatment, at 4 and 12-month follow-up. Also, socio-demographic, clinical, lifestyle, and mortality data were collected. The association between before start of treatment DS (HADS-depression > 7) and course (never DS, recovered from DS, or persistent/recurrent/late DS at 12-month follow-up) and survival was investigated using Cox regression. Unadjusted and adjusted analyses were performed.Results: In total, 384 of the 2144 persons (18%) reported pretreatment DS. Regarding DS course, 63% never had DS, 16% recovered, and 20% had persistent/recurrent/late DS. People with pretreatment DS had a higher risk of earlier death than people without DS (hazard ratio (HR) = 1.65; 95% confidence interval (CI) 1.33-2.05), but this decreased after correcting for socio-demographic, clinical, and lifestyle-related factors (HR = 1.21; 95% CI 0.97-1.52). Regarding the course of DS, people with persistent/recurrent/late DS had a higher risk of earlier death (HR = 2.04; 95% CI 1.36-3.05), while people who recovered had a comparable risk (HR = 1.12; 95% CI 0.66-1.90) as the reference group who never experienced DS. After correcting for socio-demographic and clinical factors, people with persistent/recurrent/late DS still had a higher risk of earlier death (HR = 1.66; 95% CI 1.09-2.53).Conclusions: Pretreatment DS and persistent/recurrent/late DS were associated with worse survival among people with HNC. [ABSTRACT FROM AUTHOR]- Published
- 2018
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19. Cost-utility analysis of meaning-centered group psychotherapy for cancer survivors.
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van der Spek, Nadia, Jansen, Femke, Holtmaat, Karen, Vos, Joël, Breitbart, William, van Uden‐Kraan, Cornelia F., Tollenaar, Rob A. E. M., Cuijpers, Pim, Coupé, Veerle M. H., Verdonck‐de Leeuw, Irma M., van Uden-Kraan, Cornelia F, and Verdonck-de Leeuw, Irma M
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CANCER patient psychology ,MENTAL health of cancer patients ,PSYCHOTHERAPY ,CANCER patient care ,PSYCHOLOGICAL distress ,PREVENTION - Abstract
Background: Meaning-centered group psychotherapy for cancer survivors (MCGP-CS) improves meaning, psychological well-being, and mental adjustment to cancer and reduces psychological distress. This randomized controlled trial was conducted to investigate the cost-utility of MCGP-CS compared with supportive group psychotherapy (SGP) and care-as-usual (CAU).Methods: In total, 170 patients were randomized to MCGP-CS, SGP, or CAU. Intervention costs, direct medical and nonmedical costs, productivity losses, and health-related quality of life were measured until 6 months follow-up, using the TIC-P, PRODISQ, data from the hospital information system, and the EQ-5D. The cost-utility was calculated by comparing mean cumulative costs and quality-adjusted life years (QALYs).Results: Mean total costs ranged from €4492 (MCGP-CS) to €5304 (CAU). Mean QALYs ranged .507 (CAU) to .540 (MCGP-CS). MCGP-CS had a probability of 74% to be both less costly and more effective than CAU, and 49% compared with SGP. Sensitivity analyses showed these findings are robust. If society is willing to pay €0 for one gained QALY, MCGP-CS has a 78% probability of being cost-effective compared with CAU. This increases to 85% and 92% at willingness-to-pay thresholds of €10 000 and €30 000, which are commonly accepted thresholds.Conclusions: MCGP-CS is highly likely a cost-effective intervention, meaning that there is a positive balance between the costs and gains of MCGP-CS, in comparison with SGP and CAU. [ABSTRACT FROM AUTHOR]- Published
- 2018
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20. An eHealth Application in Head and Neck Cancer Survivorship Care: Health Care Professionals' Perspectives
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Duman-Lubberding, Sanne, van Uden-Kraan, Cornelia F, Peek, Niels, Cuijpers, Pim, Leemans, C René, Verdonck-de Leeuw, Irma M, Clinical Psychology, EMGO+ - Mental Health, Otolaryngology / Head & Neck Surgery, EMGO - Mental health, and CCA - Quality of life
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Adult ,Telemedicine ,Health Personnel ,education ,Health Informatics ,participatory design approach ,follow-up care ,Quality of life (healthcare) ,Nursing ,SDG 3 - Good Health and Well-being ,Participatory design ,Health care ,eHealth ,Added value ,cancer ,Humans ,Medicine ,Survivors ,health care economics and organizations ,Aged ,Point of care ,Original Paper ,business.industry ,tertiary prevention ,Middle Aged ,humanities ,supportive care ,Survival Rate ,Attitude ,Head and Neck Neoplasms ,Quality of Life ,Female ,business ,Tertiary Prevention - Abstract
Background: Although many cancer survivors could benefit from supportive care, they often do not utilize such services. Previous studies have shown that patient-reported outcomes (PROs) could be a solution to meet cancer survivors’ needs, for example through an eHealth application that monitors quality of life and provides personalized advice and supportive care options. In order to develop an effective application that can successfully be implemented in current health care, it is important to include health care professionals in the development process. Objective: The aim of this study was to investigate health care professionals’ perspectives toward follow-up care and an eHealth application, OncoKompas, in follow-up cancer care that monitors quality of life via PROs, followed by automatically generated tailored feedback and personalized advice on supportive care. Methods: Health care professionals involved in head and neck cancer care (N=11) were interviewed on current follow-up care and the anticipated value of the proposed eHealth application (Step 1). A prototype of the eHealth application, OncoKompas, was developed (Step 2). Cognitive walkthroughs were conducted among health care professionals (N=21) to investigate perceived usability (Step 3). Interviews were recorded, transcribed verbatim, and analyzed by 2 coders. Results: Health care professionals indicated several barriers in current follow-up care including difficulties in detecting symptoms, patients’ perceived need for supportive care, and a lack of time to encourage survivors to obtain supportive care. Health care professionals expected the eHealth application to be of added value. The cognitive walkthroughs demonstrated that health care professionals emphasized the importance of tailoring care. They considered the navigation structure of OncoKompas to be complex. Health care professionals differed in their opinion toward the best strategy to implement the application in clinical practice but indicated that it should be incorporated in the HNC cancer care pathway to ensure all survivors would benefit. Conclusions: Health care professionals experienced several barriers in directing patients to supportive care. They were positive toward the development and implementation of an eHealth application and expected it could support survivors in obtaining supportive care tailored to their needs. The cognitive walkthroughs revealed several points for optimizing the application prototype and developing an efficient implementation strategy. Including health care professionals in an early phase of a participatory design approach is valuable in developing an eHealth application and an implementation strategy meeting stakeholders’ needs. [J Med Internet Res 2015;17(10):e235]
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- 2015
21. Targeting Exercise Interventions to Patients With Cancer in Need: An Individual Patient Data Meta-Analysis.
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Buffart, Laurien M, Sweegers, Maike G, May, Anne M, Chinapaw, Mai J, Vulpen, Jonna K van, Newton, Rob U, Galvão, Daniel A, Aaronson, Neil K, Stuiver, Martijn M, Jacobsen, Paul B, van Vulpen, Jonna K, Verdonck-de Leeuw, Irma M, Steindorf, Karen, Irwin, Melinda L, Hayes, Sandi, Griffith, Kathleen A, Lucia, Alejandro, Herrero-Roman, Fernando, Mesters, Ilse, and van Weert, Ellen
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CANCER patients ,CANCER treatment ,EXERCISE ,META-analysis ,QUALITY of life - Abstract
Background: Exercise effects in cancer patients often appear modest, possibly because interventions rarely target patients most in need. This study investigated the moderator effects of baseline values on the exercise outcomes of fatigue, aerobic fitness, muscle strength, quality of life (QoL), and self-reported physical function (PF) in cancer patients during and post-treatment.Methods: Individual patient data from 34 randomized exercise trials (n = 4519) were pooled. Linear mixed-effect models were used to study moderator effects of baseline values on exercise intervention outcomes and to determine whether these moderator effects differed by intervention timing (during vs post-treatment). All statistical tests were two-sided.Results: Moderator effects of baseline fatigue and PF were consistent across intervention timing, with greater effects in patients with worse fatigue (Pinteraction = .05) and worse PF (Pinteraction = .003). Moderator effects of baseline aerobic fitness, muscle strength, and QoL differed by intervention timing. During treatment, effects on aerobic fitness were greater for patients with better baseline aerobic fitness (Pinteraction = .002). Post-treatment, effects on upper (Pinteraction < .001) and lower (Pinteraction = .01) body muscle strength and QoL (Pinteraction < .001) were greater in patients with worse baseline values.Conclusion: Although exercise should be encouraged for most cancer patients during and post-treatments, targeting specific subgroups may be especially beneficial and cost effective. For fatigue and PF, interventions during and post-treatment should target patients with high fatigue and low PF. During treatment, patients experience benefit for muscle strength and QoL regardless of baseline values; however, only patients with low baseline values benefit post-treatment. For aerobic fitness, patients with low baseline values do not appear to benefit from exercise during treatment. [ABSTRACT FROM AUTHOR]- Published
- 2018
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22. A systematic review of the measurement properties of the European Organisation for Research and Treatment of Cancer In-patient Satisfaction with Care Questionnaire, the EORTC IN-PATSAT32.
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Neijenhuijs, Koen I., Jansen, Femke, Aaronson, Neil K., Brédart, Anne, Groenvold, Mogens, Holzner, Bernhard, Terwee, Caroline B., Cuijpers, Pim, and Verdonck-De Leeuw, Irma M.
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CANCER treatment ,TREATMENT effectiveness ,PATIENT satisfaction ,PSYCHOMETRICS ,SYSTEMATIC reviews ,TUMOR treatment ,TUMORS ,QUALITATIVE research - Abstract
Purpose: The EORTC IN-PATSAT32 is a patient-reported outcome measure (PROM) to assess cancer patients' satisfaction with in-patient health care. The aim of this study was to investigate whether the initial good measurement properties of the IN-PATSAT32 are confirmed in new studies.Methods: Within the scope of a larger systematic review study (Prospero ID 42017057237), a systematic search was performed of Embase, Medline, PsycINFO, and Web of Science for studies that investigated measurement properties of the IN-PATSAT32 up to July 2017. Study quality was assessed, data were extracted, and synthesized according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) methodology.Results: Nine studies were included in this review. The evidence on reliability and construct validity were rated as sufficient and of the quality of the evidence as moderate. The evidence on structural validity was rated as insufficient and of low quality. The evidence on internal consistency was indeterminate. Measurement error, responsiveness, criterion validity, and cross-cultural validity were not reported in the included studies. Measurement error could be calculated for two studies and was judged indeterminate.Conclusion: In summary, the IN-PATSAT32 performs as expected with respect to reliability and construct validity. No firm conclusions can be made yet whether the IN-PATSAT32 also performs as well with respect to structural validity and internal consistency. Further research on these measurement properties of the PROM is therefore needed as well as on measurement error, responsiveness, criterion validity, and cross-cultural validity. For future studies, it is recommended to take the COSMIN methodology into account. [ABSTRACT FROM AUTHOR]- Published
- 2018
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23. A systematic review of the measurement properties of the Body Image Scale (BIS) in cancer patients.
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Cuijpers, Pim, Melissant, Heleen C., Neijenhuijs, Koen I., van Uden-Kraan, Cornelia F., Verdonck-de Leeuw, Irma M., Jansen, Femke, Aaronson, Neil K., Groenvold, Mogens, Holzner, Bernhard, and Terwee, Caroline B.
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CANCER patients ,BODY image ,CANCER treatment ,SYSTEMATIC reviews ,STATISTICAL hypothesis testing ,MENTAL health ,QUALITY of life ,TUMORS & psychology ,BODY dysmorphic disorder ,RESEARCH funding ,PSYCHOLOGICAL factors - Abstract
Introduction: Body image is acknowledged as an important aspect of health-related quality of life in cancer patients. The Body Image Scale (BIS) is a patient-reported outcome measure (PROM) to evaluate body image in cancer patients. The aim of this study was to systematically review measurement properties of the BIS among cancer patients.Methods: A search in Embase, MEDLINE, PsycINFO, and Web of Science was performed to identify studies that investigated measurement properties of the BIS (Prospero ID 42017057237). Study quality was assessed (excellent, good, fair, poor), and data were extracted and analyzed according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) methodology on structural validity, internal consistency, reliability, measurement error, hypothesis testing for construct validity, and responsiveness. Evidence was categorized into sufficient, insufficient, inconsistent, or indeterminate.Results: Nine studies were included. Evidence was sufficient for structural validity (one factor solution), internal consistency (α = 0.86-0.96), and reliability (r > 0.70); indeterminate for measurement error (information on minimal important change lacked) and responsiveness (increasing body image disturbance in only one study); and inconsistent for hypothesis testing (conflicting results). Quality of the evidence was moderate to low. No studies reported on cross-cultural validity.Conclusion: The BIS is a PROM with good structural validity, internal consistency, and test-retest reliability, but good quality studies on the other measurement properties are needed to optimize evidence. It is recommended to include a wider variety of cancer diagnoses and treatment modalities in these future studies. [ABSTRACT FROM AUTHOR]- Published
- 2018
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24. Intent to use a web-based psychological intervention for partners of cancer patients: Associated factors and preferences.
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Köhle, Nadine, Drossaert, Constance H. C., Van Uden-Kraan, Cornelia F., Schreurs, Karlein M. G., Hagedoorn, Mariët, Verdonck-de Leeuw, Irma M., and Bohlmeijer, Ernst T.
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ATTITUDE (Psychology) ,CANCER patients ,COMPUTERS ,INTENTION ,SERVICES for caregivers ,QUESTIONNAIRES ,WORLD Wide Web ,SAMPLE size (Statistics) ,DATA analysis software ,DESCRIPTIVE statistics - Abstract
This study examined partners of cancer patients intention to use a web-based psychological intervention, their preferences regarding its preconditions, functionalities and topics, and factors related to their intention. One hundred and sixty-eight partners completed a questionnaire about these aspects. Forty-eight percent of the partners would (maybe) make use of a web-based intervention. Partners who intended to participate were significantly younger, used the Internet more often, and perceived more caregiver strain. Most partners preferred an intervention that takes less than 1 hour/week, lasts five weeks or more, and contains information and peer support. Half of the partners would like to receive online guidance. [ABSTRACT FROM PUBLISHER]
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- 2018
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25. Moderators of the effects of meaning-centered group psychotherapy in cancer survivors on personal meaning, psychological well-being, and distress.
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Spek, Nadia, Verdonck-de Leeuw, Irma, Holtmaat, Karen, Witte, Birgit, Breitbart, William, Cuijpers, Pim, van der Spek, Nadia, Witte, Birgit I, and Verdonck-de Leeuw, Irma M
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PSYCHOTHERAPY ,CANCER patient psychology ,MENTAL health of cancer patients ,WELL-being ,ONCOLOGY - Abstract
Purpose: There is evidence to support that meaning-centered group psychotherapy for cancer survivors (MCGP-CS) is an effective intervention for improving personal meaning and psychological well-being, as well as reducing psychological distress. In order to investigate which subpopulations MCGP-CS specifically benefits, this explorative study aims to analyze potential sociodemographic, clinical, and psychosocial factors that may moderate the effects.Methods: Cancer survivors (N = 114) were randomly assigned to MCGP-CS, or care as usual (CAU). Potential moderators included age, sex, relationship, education, employment, religion, cancer type, tumor stage, cancer treatment, time since treatment, anxiety, depression, other negative life events, and previous psychological treatment. Outcome measures were the Personal Meaning Profile (PMP), Scales of Psychological Well-Being (SPWB), and the Hospital Anxiety and Depression Scale (HADS). Assessment took place at baseline, post-intervention (short-term), and 3- and 6-month follow-ups (long-term). For each moderator, separate short-term and long-term linear mixed models were built.Results: Short-term effect of MCGP-CS was moderated by (male) sex (on HADS-D; F(1,98) = 6.1, p = .015) and (a high level of) depressive symptoms at baseline (on SPWB; F(1,93) = 5.7, p = .019). Long-term effect of MCGP-CS was moderated by (not having received) previous psychological treatment (on HADS-total; F(3253) = 3.4, p = .017).Conclusions: Most sociodemographic and clinical characteristics do not appear to moderate the positive effect of MCGP-CS on personal meaning. However, MCGP-CS appears to reduce depressive symptoms, particularly in males, and to improve purpose in life of survivors with depressive symptoms. In the long-term, MCGP-CS appears to reduce psychological distress in survivors who had not received psychological treatment in the past year.Trial Registration: NTR3571. [ABSTRACT FROM AUTHOR]- Published
- 2017
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26. User-experiences with a web-based self-help intervention for partners of cancer patients based on acceptance and commitment therapy and self-compassion: a qualitative study.
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Köhle, Nadine, Drossaert, Constance H. C., Jaran, Jasmijn, Schreurs, Karlein M. G., Verdonck-de Leeuw, Irma M., Bohlmeijer, Ernst T., and Leeuw, Irma M Verdonck-de
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CANCER patient medical care ,ACCEPTANCE & commitment therapy ,COMPASSION ,WEB-based user interfaces ,RESPONSIBILITY ,PSYCHOLOGY ,TUMOR treatment ,TUMORS & psychology ,ADAPTABILITY (Personality) ,EMPATHY ,HEALTH behavior ,INTERNET ,PROBLEM solving ,SUPPORT groups ,QUALITATIVE research ,SEXUAL partners - Abstract
Background: Partners of cancer patients are the cornerstone of supportive cancer care. They assume different roles and responsibilities that optimally support the patient. Such support is highly demanding, and many partners report (mental) health problems. However, many of them do not use professional supportive care themselves. Offering a Web-based self-help intervention based on Acceptance and Commitment Therapy (ACT) and self-compassion could be an important resource to support this group. This qualitative study aimed to examine user-experiences with a Web-based self-help intervention based on ACT and self-compassion among partners of cancer patients.Methods: Individual in-depth interviews, about partners' appreciation of the intervention and lessons learned, were conducted with 14 partners of cancer patients who used the Web-based self-help intervention. Interviews were audio-recorded, transcribed verbatim and analyzed by three independent coders both deductively and inductively.Results: In general, partners appreciated the intervention, however, they also expressed ambivalent feelings towards peer support, the content of the feedback of their counselor, and the 'tunneled' structure of the intervention. The majority of the partners reported being more self-compassionate accepting that they experienced negative thoughts and feelings, they reported that they learned to increase the distance between their thoughts and themselves, they indicated being more aware of their personal values, and they thought that they were better able to commit to those values. They also reported other (non-specific) helpful processes such as insight and acknowledgement, positivity, the possibility to tell their story, time for themselves, and feeling closer and more connected with their partner (the patient).Conclusions: Partners of cancer patients indicated to appreciate the Web-based self-help intervention based on ACT and self-compassion. They felt that the intervention helped them to cope with negative emotions, thoughts, and one's suffering; to practice self-kindness; and to clarify values based on difficult recent experiences. In addition, they felt that the intervention supported them to obtain insight and acknowledgement, positivity, to tell their story, make time for themselves, and feeling closer and more connected with the patient. We think that a Web-based psychological intervention based on ACT and self-compassion may be a valuable contribution in supporting partners of cancer patients. [ABSTRACT FROM AUTHOR]- Published
- 2017
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27. Cognitive coping style (monitoring and blunting) and the need for information, information satisfaction and shared decision making among patients with haematological malignancies.
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Rood, Janneke A. J., Van Zuuren, Florence J., Stam, Frank, Ploeg, Tjeerd, Huijgens, Peter C., and Verdonck‐ de Leeuw, Irma M.
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PSYCHO-oncology ,CANCER pain treatment ,COGNITION ,QUALITY of life ,HEMATOLOGY - Abstract
Objective A haematological malignancy is a serious, life-altering disease and may be characterised as an uncontrollable and unpredictable stress situation. In dealing with potentially threatening information, individuals generally utilise two main cognitive coping styles: monitoring (the tendency to seek threat-relevant information) and blunting (avoiding threatening information and seeking distraction). The aim of this study was to obtain insight into the association between cognitive coping style and (a) need for information, (b) satisfaction with information, (c) involvement in decision making, and (d) quality of life (QoL). Methods In this cross-sectional study, coping style was assessed among adult patients diagnosed with a haematological malignancy, using an adapted version of the Threatening Medical Situations Inventory. Information need, information satisfaction, decision-making preference and QoL were measured with validated questionnaires. Results In total, 458 patients returned the questionnaire (66%). A monitoring coping style was positively related to need for both general and specific information. Blunting was positively and QoL was negatively related to need for information. Monitoring was positively related to involvement in decision-making and negatively to information satisfaction. Using multivariate analysis, this relation between monitoring and information satisfaction disappeared, and for blunting, we found a negatively significant relation. QoL was not related to coping style. Conclusions Among patients with haematological malignancies, coping style is related to a need for information, information satisfaction, and involvement in treatment decision-making. Therefore, it is important for health care professionals to be aware of individual differences in cognitive coping style. Copyright © 2014 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
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- 2015
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28. Meaning-centered group psychotherapy in cancer survivors: a feasibility study.
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Spek, Nadia, Uden‐Kraan, Cornelia F., Vos, Joël, Breitbart, William, Tollenaar, Rob A. E. M., Asperen, Christi J., Cuijpers, Pim, and Verdonck‐de Leeuw, Irma M.
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FEASIBILITY studies ,GROUP psychotherapy ,GROUP counseling ,CANCER treatment ,CANCER patient medical care ,PSYCHOLOGY - Abstract
The article presents a feasibility study that examines the meaning-centered group psychotherapy (MCGP) of cancer survivors. The study proves MCGP's good acceptability, client satisfaction, recruitment strategies, compliance and good acceptability in cancer survivors. Also revealed are the benefits of MCGP to cancer survivors.
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- 2014
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29. Effectiveness and cost-effectiveness of meaning-centered group psychotherapy in cancer survivors: protocol of a randomized controlled trial.
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van der Spek, Nadia, Vos, Joël, van Uden-Kraan, Cornelia F., Breitbart, William, Cuijpers, Pim, Knipscheer-Kuipers, Kitty, Willemsen, Vincent, Tollenaar, Rob AEM, van Asperen, Christi J., and Verdonck-de Leeuw, Irma M.
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COST effectiveness ,PSYCHOTHERAPY ,CANCER treatment ,RANDOMIZED controlled trials ,TREATMENT effectiveness ,HOSPITALS - Abstract
Background Meaning-focused coping may be at the core of adequate adjustment to life after cancer. Cancer survivors who experience their life as meaningful are better adjusted, have better quality of life and psychological functioning. Meaning-Centered Group Psychotherapy for Cancer Survivors (MCGP-CS) was designed to help patients to sustain or enhance a sense of meaning and purpose in their lives. The aim of the proposed study is to evaluate the effectiveness and cost-effectiveness of MCGP-CS. Methods/design Survivors diagnosed with cancer in the last 5 years and treated with curative intent, are recruited via several hospitals in the Netherlands. After screening, 168 survivors are randomly assigned to one of the three study arms: 1. Meaning-Centered Group Psychotherapy (MCGP-CS) 2. Supportive group psychotherapy (SGP) 3. Care as usual (CAU). Baseline assessment takes place before randomisation, with follow up assessments post-intervention and at 3, 6 and 12 months follow-up. Primary outcome is meaning making (PMP, PTGI, SPWB). Secondary outcome measures address quality of life (EORTC-30), anxiety and depression (HADS), hopelessness (BHS), optimism (LOT-R), adjustment to cancer (MAC), and costs (TIC-P, EQ-5D, PRODISQ). Discussion Meaning-focused coping is key to adjustment to life after cancer, however, there is a lack of evidence based psychological interventions in this area. Many cancer survivors experience feelings of loneliness and alienation, and have a need for peer support, therefore a group method in particular, can be beneficial for sustaining or enhancing a sense of meaning. If this MCGP-CS is effective for cancer survivors, it can be implemented in the practice of psycho- oncology care. Trial registration NTR3571 [ABSTRACT FROM AUTHOR]
- Published
- 2014
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30. Stepped care targeting psychological distress in head and neck and lung cancer patients: a randomized clinical trial.
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Krebber, Anne-Marie H., Leemans, C. René, de Bree, Remco, van Straten, Annemieke, Smit, Filip, Smit, Egbert F., Becker, Annemarie, Eeckhout, Guus M., Beekman, Aartjan TF, Cuijpers, Pim, and Verdonck-de Leeuw, Irma M.
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PSYCHOLOGICAL distress ,CANCER patients ,CLINICAL trials ,MEDICAL care costs ,LUNG cancer - Abstract
Background: Psychological distress is common in cancer survivors. Although there is some evidence on effectiveness of psychosocial care in distressed cancer patients, referral rate is low. Lack of adequate screening instruments in oncology settings and insufficient availability of traditional models of psychosocial care are the main barriers. A stepped care approach has the potential to improve the efficiency of psychosocial care. The aim of the study described herein is to evaluate efficacy of a stepped care strategy targeting psychological distress in cancer survivors. Methods/design: The study is designed as a randomized clinical trial with 2 treatment arms: a stepped care intervention programme versus care as usual. Patients treated for head and neck cancer (HNC) or lung cancer (LC) are screened for distress using OncoQuest, a computerized touchscreen system. After stratification for tumour (HNC vs. LC) and stage (stage I/II vs. III/IV), 176 distressed patients are randomly assigned to the intervention or control group. Patients in the intervention group will follow a stepped care model with 4 evidence based steps: 1. Watchful waiting, 2. Guided self-help via Internet or a booklet, 3. Problem Solving Treatment administered by a specialized nurse, and 4. Specialized psychological intervention or antidepressant medication. In the control group, patients receive care as usual which most often is a single interview or referral to specialized intervention. Primary outcome is the Hospital Anxiety and Depression Scale (HADS). Secondary outcome measures are a clinical level of depression or anxiety (CIDI), quality of life (EQ-5D, EORTC QLQ-C30, QLQ-HN35, QLQ-LC13), patient satisfaction with care (EORTC QLQ-PATSAT), and costs (health care utilization and work loss (TIC-P and PRODISQ modules)). Outcomes are evaluated before and after intervention and at 3, 6, 9 and 12 months after intervention. Discussion: Stepped care is a system of delivering and monitoring treatments, such that effective, yet least resource-intensive, treatment is delivered to patients first. The main aim of a stepped care approach is to simplify the patient pathway, provide access to more patients and to improve patient well-being and cost reduction by directing, where appropriate, patients to low cost (self-)management before high cost specialist services. Trial registration: NTR1868 [ABSTRACT FROM AUTHOR]
- Published
- 2012
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31. A nurse-led self-management support intervention for patients and informal caregivers facing incurable cancer: A feasibility study from the perspective of nurses.
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Slev, Vina N., Molenkamp, Cornelia M., Eeltink, Corien M., Roeline W Pasman, H., Verdonck-de Leeuw, Irma M., Francke, Anneke L., and van Uden-Kraan, Cornelia F.
- Abstract
Investigation of the feasibility of recruitment through nurses of patients with incurable cancer, and the feasibility (adoption, usage) and nurses' evaluation of a nurse-led self-management support intervention, integrated in continuity home visits and based on the 5 A's Behavior Change Model. Questionnaire, registrations, evaluation forms, and interviews. Recruitment was complicated; many patients were ineligible for participation, nurses appeared protective of their patients (gatekeeping), and recruitment during the first continuity home visit appeared to be a barrier as a lot of other issues had to be discussed. The adoption rate was 81%, meaning that 18 out of 22 nurses recruited were willing to use the intervention. The usage rate at the nurse level was 56%, meaning that 10 nurses applied the intervention in full (having applied all five A's) in at least one patient. Nurses used the intervention in full in 21 out of the 36 patients included, implying a usage rate at the patient level of 58%. Nurses' mean general satisfaction score for the intervention was 7.57 (range 0–10). Nurse were especially positive about the 5 A's model, and considered the continuity home visits to be an appropriate setting for the intervention. Timing of recruitment and gatekeeping complicated recruitment of patients through nurses. Although nurses were positive about the intervention, nurses often did not fully apply the intervention. To improve its usage, it is suggested that nurses should first be trained in using the 5 A's model. • Nurses regarded continuity home visits an appropriate setting for the intervention. • Nurses were positive about the 5 A's model for structuring self-management support. • Usage rates showed that 'Assist' and 'Arrange' of the 5 A's model are applied least. • Nurses need extra training in applying the A's Assist and Arrange of the 5A's model. [ABSTRACT FROM AUTHOR]
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- 2020
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32. Transcending the Suffering in Cancer: Impact of a Spiritual Life Review Intervention on Spiritual Re-Evaluation, Spiritual Growth and Psycho-Spiritual Wellbeing.
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Post, Lenneke, Ganzevoort, R. Ruard, and Verdonck-de Leeuw, Irma M.
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SPIRITUAL life ,WELL-being - Abstract
In the confrontation with cancer, spiritual re-evaluation may help people to transform all-encompassing suffering into spiritual growth and psycho-spiritual wellbeing. The aim of this study was to examine whether spiritual life review (SLR), a semi-structured group narrative intervention that supports people with cancer to write and present their spiritual life story, is effective for the improvement of spiritual re-evaluation, spiritual growth, and psycho-spiritual wellbeing. In this mixed methods study, 57 cancer patients participated. Quantitative data were collected by means of patient reported outcomes (SAIL, Dutch Ryff, and NEIS) at baseline, post-intervention, and three and nine months follow-up (44 participants completed up to 9 months post-intervention). Changes over time were assessed via linear mixed model analysis (LMM). Qualitative data were collected by means of semi-structured interviews with 33 participants nine months post-intervention, and were coded in a two-stage process. Participating in SLR facilitated spiritual re-evaluation, and improved the course of spiritual growth, psycho-spiritual wellbeing, and ego-integrity. This study provides evidence that SLR is likely to improve spiritual re-evaluation, spiritual growth, and psycho-spiritual wellbeing after confrontation with cancer; it also suggests the importance of self-affirmation and ego-integrity for spirituality; and underscores the relevance of narrative spiritual interventions in the oncology setting. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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33. Hold on, for each other
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Nadine Köhle, Bohlmeijer, Ernst T., Verdonck-de Leeuw, Irma M., Drossaert, Stans C.H.C., and Psychology, Health & Technology
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Psychotherapist ,business.industry ,Psychological intervention ,Pillar ,Cancer ,medicine.disease ,Acceptance and commitment therapy ,Participatory development ,Nursing ,Intervention (counseling) ,medicine ,eHealth ,Positive psychology ,business - Abstract
Partners of cancer patients are an essential pillar in the cancer trajectory. The patient’s cancer can have an enormous impact on the partner’s life and (mental) health. To support them, psychological interventions are needed. However, partners of cancer patients are often extremely busy and supporting them can be challenging. Web-based intervention offer a possible solution to aiding partners since such interventions circumvent caregivers’ time restraints and daily, unpredictable demands. To fulfil partners’ needs and meet their challenges, the main aim of this research project was to develop and evaluate a psychological Web-based self-help intervention for partners of cancer patients that would be based on acceptance and commitment therapy (ACT) and self-compassion. In this thesis, we describe the participatory development of the Web-based intervention Hold on, for each other and its evaluation with the use of mixed-methods. Based on the studies in this thesis it can be concluded that a Web-based self-help intervention is a good alternative for partners of cancer patients, that processes of ACT and self-compassion are useful and applicable to this target group, and that co-creation is essential to develop an acceptable and user-friendly Web-based intervention. This thesis has contributed to the growing awareness of the challenging situation partners of cancer patients are confronted with. Although we focused on partners of cancer patients, we think that the obtained insights are also of great value and potentially helpful for other groups, such as all caregivers of cancer patients and also partners and caregivers of patients suffering from other chronic diseases.
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- 2016
34. Swallowing dysfunction in cancer patients
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René-Jean Bensadoun, Judith E. Raber-Durlacher, Monica C. Fliedner, Sol Silverman, Tuomas Waltimo, Aniel Sewnaik, Irma M. Verdonck-de Leeuw, Thomas P. Sollecito, June G. Eilers, Tanya S. Rouleau, Marisol Michelet, Mike T. Brennan, Casper P. Bots, Fred K. L. Spijkervet, Rachel J. Gibson, EMGO+ - Mental Health, Orale Biochemie (OII, ACTA), Parodontologie (OII, ACTA), Otolaryngology / Head & Neck Surgery, EMGO - Mental health, CCA - Quality of life, Raber-Durlacher, Judith E., Brennan, Mike T., Verdonck-de, Leeuw Irma M., Gibson, Rachel J., Eilers, June G., Waltimo, Tuomas, Bots, Casper P., Michelet, Marisol, Sollecito, Thomas P., Rouleau, Tanya S., Sewnaik, Aniel, Bensadoun, Rene-Jean, Fliedner, Monica C., Silverman, Sol, Spijkervet, Fred K. L., Oral Biochemistry, and Periodontology
- Subjects
dysphagia ,LONGITUDINAL ASSESSMENT ,Comorbidity ,Review Article ,Postoperative Complications ,NECK-CANCER ,Quality of life ,QUALITY-OF-LIFE ,Neoplasms ,VERSUS-HOST-DISEASE ,Prevalence ,chemoradiation ,Cancer ,INFLUENCING DYSPHAGIA SEVERITY ,Chemoradiotherapy ,Dysphagia ,Deglutition disorders ,Causality ,ErbB Receptors ,Chemoradiation ,Oncology ,medicine.symptom ,REDUCE DYSPHAGIA ,medicine.medical_specialty ,ADVANCED HEAD ,Antineoplastic Agents ,Xerostomia ,Head and neck neoplasms ,head and neck neoplasms ,Swallowing ,SDG 3 - Good Health and Well-being ,swallowing dysfunction ,medicine ,otorhinolaryngologic diseases ,cancer ,Humans ,Intensive care medicine ,PERFORMANCE STATUS SCALE ,aspiration ,business.industry ,Head and neck cancer ,deglutition disorders ,Swallowing dysfunction ,medicine.disease ,Surgery ,INTENSITY-MODULATED RADIOTHERAPY ,Aspiration ,Quality of Life ,ORAL-CANCER ,Complication ,business - Abstract
PurposeDysphagia (swallowing dysfunction) is a debilitating, depressing, and potentially life-threatening complication in cancer patients that is likely underreported. The present paper is aimed to review relevant dysphagia literature between 1990 and 2010 with a focus on assessment tools, prevalence, complications, and impact on quality of life in patients with a variety of different cancers, particularly in those treated with curative chemoradiation for head and neck cancer.MethodsThe literature search was limited to the English language and included both MEDLINE/PubMed and EMBASE. The search focused on papers reporting dysphagia as a side effect of cancer and cancer therapy. We identified relevant literature through the primary literature search and by articles identified in references.ResultsA wide range of assessment tools for dysphagia was identified. Dysphagia is related to a number of factors such as direct impact of the tumor, cancer resection, chemotherapy, and radiotherapy and to newer therapies such as epidermal growth factor receptor inhibitors. Concomitant oral complications such as xerostomia may exacerbate subjective dysphagia. Most literature focuses on head and neck cancer, but dysphagia is also common in other types of cancer.ConclusionsSwallowing impairment is a clinically relevant acute and long-term complication in patients with a wide variety of cancers. More prospective studies on the course of dysphagia and impact on quality of life from baseline to long-term follow-up after various treatment modalities, including targeted therapies, are needed.
- Published
- 2012
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