1. Incidence and survival of sinonasal adenocarcinoma by site and histologic subtype.
- Author
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Kılıç, Suat, Samarrai, Ruwaa, Kılıç, Sarah S., Mikhael, Mina, Baredes, Soly, and Eloy, Jean Anderson
- Subjects
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BLACK people , *ADENOCARCINOMA , *MAXILLARY sinus , *NASAL cavity , *PARANASAL sinuses , *NASAL tumors , *SURVIVAL , *SYSTEMATIC reviews , *DISEASE incidence , *RETROSPECTIVE studies , *PROGNOSIS , *DIAGNOSIS - Abstract
Objective: To determine the incidence and survival of sinonasal adenocarcinoma (SNAC) by subsite and histologic subtype. Study design: Retrospective database review. Methods: Using the SEER database, we performed a retrospective analysis, identified cases of SNAC diagnosed between 1973 and 2013 and analyzed demographic, histopathology, clinicopathology, and determinants of disease specific survival (DSS). Results: A total of 746 patients with SNAC were identified. Median age at diagnosis was 64 years. Overall incidence was 0.44 per million, and was higher among blacks (O.R.:1.10-2.07:1) and males (O.R.:1.38-2.06:1). Nasal cavity (41.5%) was the most common site, followed by maxillary (26.5%), and ethmoid (17.4%) sinuses. Intestinal-type adenocarcinoma was less likely than Adenocarcinoma not otherwise specified (ANOS) to be found in the maxillary sinus (8.8% vs. 30.6%, p<.05). Surgery alone (48.56%) was the most common treatment modality, followed by surgery and radiotherapy (RT) (32.5%), and RT alone (11.6%). DSS at 5, 10, and 20 years were 63.8%, 57.6%, and 47.0%, respectively. DSS was higher for nasal cavity SNAC, lower grade, lower stage, and those receiving surgery only. Conclusions: SNAC is more common among men and blacks. Incidence has not changed significantly in the past 40 years. Survival varies with grade, stage, histology, subsite, and treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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