1. Guidelines for the welfare and use of animals in cancer research
- Author
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Workman, P, Aboagye, EO, Balkwill, F, Balmain, A, Bruder, G, Chaplin, DJ, Double, JA, Everitt, J, Farningham, DAH, Glennie, MJ, Kelland, LR, Robinson, V, Stratford, IJ, Tozer, GM, Watson, S, Wedge, SR, and Eccles, SA
- Subjects
Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Cancer ,5.9 Resources and infrastructure (treatment development) ,2.6 Resources and infrastructure (aetiology) ,Aetiology ,Development of treatments and therapeutic interventions ,Disputed aetiology and other ,Algorithms ,Animal Experimentation ,Animal Welfare ,Animals ,Biomarkers ,Pharmacological ,Biomedical Research ,Cell Line ,Transformed ,Diagnostic Imaging ,Disease Models ,Animal ,Female ,Humans ,Male ,Mice ,Neoplasm Transplantation ,Neoplasms ,Practice Guidelines as Topic ,Treatment Outcome ,Xenograft Model Antitumor Assays ,animal welfare ,cancer research ,fundamental and translational research ,replacement ,reduction and refinement ,pilot studies ,tumour models ,genetically engineered mouse models ,human tumour xenografts ,orthotopic models ,metastatic models ,therapy ,imaging ,pharmocokinetic ,pharmacodynamic and efficacy studies ,drugs ,radiation therapy ,imaging techniques ,anaesthesia ,restraint ,humane endpoints ,tumour burden ,clinical signs ,publication ,best practice ,Committee of the National Cancer Research Institute ,Public Health and Health Services ,Oncology & Carcinogenesis ,Oncology and carcinogenesis - Abstract
Animal experiments remain essential to understand the fundamental mechanisms underpinning malignancy and to discover improved methods to prevent, diagnose and treat cancer. Excellent standards of animal care are fully consistent with the conduct of high quality cancer research. Here we provide updated guidelines on the welfare and use of animals in cancer research. All experiments should incorporate the 3Rs: replacement, reduction and refinement. Focusing on animal welfare, we present recommendations on all aspects of cancer research, including: study design, statistics and pilot studies; choice of tumour models (e.g., genetically engineered, orthotopic and metastatic); therapy (including drugs and radiation); imaging (covering techniques, anaesthesia and restraint); humane endpoints (including tumour burden and site); and publication of best practice.
- Published
- 2010