1. Glioblastoma Cellular Origin and the Firework Pattern of Cancer Genesis from the Subventricular Zone
- Author
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Joo Ho Lee, Euna Jo, Ran Joo Choi, Junseong Park, Jong Hee Chang, Dong Su Jang, Ju Hyung Moon, Seon Jin Yoon, Jin Kyung Shim, Jeong Ho Lee, Hyunjung Kim, Eui Hyun Kim, and Seok Gu Kang
- Subjects
Senescence ,Subventricular zone ,Cell of origin ,Brain tumor ,Disease ,Review Article ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Clock-like mutation ,medicine ,Firework pattern ,business.industry ,General Neuroscience ,Cancer ,Cancer genesis ,medicine.disease ,Isocitrate dehydrogenase ,medicine.anatomical_structure ,Cancer research ,Surgery ,Cell-of-origin ,Neurology (clinical) ,Stem cell ,business ,Glioblastoma ,030217 neurology & neurosurgery - Abstract
Glioblastoma (GBM) is a disease without any definite cure. Numerous approaches have been tested in efforts to conquer this brain disease, but patients invariably experience recurrence or develop resistance to treatment. New surgical tools, carefully chosen samples, and experimental methods are enabling discoveries at single-cell resolution. The present article reviews the cell-of-origin of isocitrate dehydrogenase (IDH)-wildtype GBM, beginning with the historical background for focusing on cellular origin and introducing the cancer genesis patterned on firework. The authors also review mutations associated with the senescence process in cells of the subventricular zone (SVZ), and biological validation of somatic mutations in a mouse SVZ model. Understanding GBM would facilitate research on the origin of other cancers and may catalyze the development of new management approaches or treatments against IDH-wildtype GBM.
- Published
- 2019