1. Cannabidiol—from Plant to Human Body: A Promising Bioactive Molecule with Multi-Target Effects in Cancer
- Author
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Zorita Diaconeasa, Ioana Zinuca Pavel, Cristina Dehelean, Diana Antal, Codruta Soica, Feng Chen Ifrim, Virgil Paunescu, Florina Ardelean, Brigitta Kis, Stefana Avram, Valentina Buda, and Corina Danciu
- Subjects
Antineoplastic Agents ,Review ,Biology ,Cannabis sativa ,Catalysis ,Brain cancer ,Inorganic Chemistry ,cannabidiol ,Multi target ,breast cancer ,glioma ,Neoplasms ,medicine ,melanoma ,Humans ,Physical and Theoretical Chemistry ,Molecular Biology ,Spectroscopy ,Cannabis ,brain cancer ,pharmacological and toxicological profile ,Traditional medicine ,Plant Extracts ,Organic Chemistry ,Cancer ,General Medicine ,medicine.disease ,prostate cancer ,Prognosis ,digestive system diseases ,Computer Science Applications ,lung cancer ,clinical evidence ,colon cancer ,immunomodulatory effects ,Clinical evidence ,Cannabidiol ,medicine.drug ,Phytotherapy - Abstract
Cannabis sativa L. is a plant long used for its textile fibers, seed oil, and oleoresin with medicinal and psychoactive properties. It is the main source of phytocannabinoids, with over 100 compounds detected so far. In recent years, a lot of attention has been given to the main phytochemicals present in Cannabis sativa L., namely, cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC). Compared to THC, CBD has non-psychoactive effects, an advantage for clinical applications of anti-tumor benefits. The review is designed to provide an update regarding the multi-target effects of CBD in different types of cancer. The main focus is on the latest in vitro and in vivo studies that present data regarding the anti-proliferative, pro-apoptotic, cytotoxic, anti-invasive, anti-antiangiogenic, anti-inflammatory, and immunomodulatory properties of CBD together with their mechanisms of action. The latest clinical evidence of the anticancer effects of CBD is also outlined. Moreover, the main aspects of the pharmacological and toxicological profiles are given.
- Published
- 2019