1. Caught in the act: in vivo development of macrolide resistance to Campylobacter jejuni infection.
- Author
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Lindow JC, Poly F, Tribble DR, Guerry P, Carmolli MP, Baqar S, Porter CK, Pierce KK, Darsley MJ, Sadigh KS, Dill EA, and Kirkpatrick BD
- Subjects
- Bacterial Typing Techniques, Campylobacter Infections microbiology, Campylobacter jejuni classification, Campylobacter jejuni genetics, Campylobacter jejuni isolation & purification, DNA Fingerprinting, DNA, Bacterial genetics, Electrophoresis, Gel, Pulsed-Field, Healthy Volunteers, Humans, Male, Microbial Sensitivity Tests, Young Adult, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents therapeutic use, Campylobacter Infections drug therapy, Campylobacter jejuni drug effects, Drug Resistance, Bacterial, Macrolides pharmacology, Macrolides therapeutic use
- Abstract
We report the first instance of macrolide resistance developing in vivo following appropriate antibiotic use in a healthy volunteer as a part of a controlled human infection with Campylobacter jejuni. In vivo development of macrolide resistance may be an important contributor to antibiotic resistance in C. jejuni.
- Published
- 2010
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