1. Microwave-assisted synthesis of borneol esters and their antimicrobial activity.
- Author
-
E Silva ATM, Pereira VV, Takahashi JA, Silva RR, and Duarte LP
- Subjects
- Anti-Bacterial Agents chemical synthesis, Anti-Bacterial Agents chemistry, Anti-Bacterial Agents pharmacology, Anti-Infective Agents chemistry, Benzoates chemistry, Candida albicans drug effects, Chemistry Techniques, Synthetic, Drug Evaluation, Preclinical methods, Escherichia coli drug effects, Esters chemistry, Microbial Sensitivity Tests, Microwaves, Pseudomonas aeruginosa drug effects, Staphylococcus aureus drug effects, Anti-Infective Agents chemical synthesis, Anti-Infective Agents pharmacology, Benzoates chemical synthesis, Benzoates pharmacology, Camphanes chemistry, Camphanes pharmacology
- Abstract
Seventeen borneol esters (1-17) were synthesised by conventional and microwave-assisted methodology using DIC/DMAP, and seven are described for the first time (8, 9, 10, 12, 13, 16 and 17). The microwave-assisted methodology was carried out without use of solvents, displayed short reaction times, and showed equal or higher yields for all the long-chain esters and three aromatic compounds (11, 12 and 14) when compared to the conventional approach. All the borneol esters were evaluated against the bacteria Streptococcus sanguinis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and the fungus Candida albicans. Compounds 12, 13 and 14 displayed promising antibacterial activity with a MIC equal to ampicilin (62.5 mg mL
-1 ) for some microorganisms. In fact, bornyl 3',4'-dimethoxybenzoate (13) was active against all tested bacteria and fungus.- Published
- 2018
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