7 results on '"Siewe Fodjo, Joseph Nelson"'
Search Results
2. Dementia Prevalence and Onchocerca volvulus Infection among Rural Elderly Persons in the Ntui Health District, Cameroon: A Population-Based Study.
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Njamnshi, Wepnyu Yembe, Siewe Fodjo, Joseph Nelson, Njamnshi, Kongnyu Gamnsi, Ngarka, Leonard, Mengnjo, Michel K., Nfor, Leonard N., Tsasse, Martine A. F., Njamnshi, Julius N. Taryunyu, Maestre, Gladys, Cavazos, Jose E., Seshadri, Sudha, Etoundi Ngoa, Laurent S., Obama Abena Ondoa, Marie-Thérèse, Fongang, Bernard, Zoung-Kanyi Bissek, Anne-Cécile, and Njamnshi, Alfred K.
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RAPID diagnostic tests ,ONCHOCERCA volvulus ,OLDER people ,SERODIAGNOSIS ,DISEASE risk factors - Abstract
Recent research suggests that infection with Onchocerca volvulus induces neurocognitive decline. This study sought to compare the cognitive outcomes of elderly persons based on onchocerciasis infection status and report the overall prevalence of dementia in the rural Ntui Health District in Cameroon. A community-based approach was used to recruit 103 participants aged ≥60 years. Dementia screening was done using the Community Screening Interview for Dementia (CSID) tool with a cut-off value of ≤29.5. O. volvulus infection was determined via microscopic examination of skin snips and serological testing of Ov16 antibodies using rapid diagnostic tests. Overall, the prevalence of dementia was 10.7%. Among the tested individuals, 17.9% (15/84) and 62.1% (41/66) were positive for O. volvulus and Ov16 antibodies, respectively. A multivariable linear regression model of CSID scores found a significant positive association with education level (8.654; 95% CI: 2.0870 to 15.222). However, having a positive skin snip for O. volvulus (−3.399; 95% CI: −6.805 to 0.007) and inhaling tobacco (−5.441; 95% CI: −9.137 to −1.744) tended to lower the CSID scores. Ongoing onchocerciasis transmission in the Ntui Health District may constitute a risk factor for dementia. Strengthening onchocerciasis elimination and adopting healthier lifestyles would contribute to dementia prevention among the elderly residing in endemic communities. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Fear and depression during the COVID-19 outbreak in Cameroon: a nation-wide observational study
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Siewe Fodjo, Joseph Nelson, Ngarka, Leonard, Njamnshi, Wepnyu Y., Nfor, Leonard N., Mengnjo, Michel K., Mendo, Edwige Laure, Angwafor, Samuel A., Atchou Basseguin, Jonas Guy, Nkouonlack, Cyrille, Njit, Edith N., Ahidjo, Nene, Chokote, Eric S., Dema, Fidèle, Fonsah, Julius Y., Tatah, Godwin Y., Palmer, Nancy, Seke Etet, Paul F., Palmer, Dennis, Nsagha, Dickson S., Etya’ale, Daniel E., Perrig, Stephen, Sztajzel, Roman, Annoni, Jean-Marie, Zoung-Kanyi Bissek, Anne-Cécile, Leke, Rose G. F., Abena Ondoa Obama, Marie-Thérèse, Nkengasong, John N., Colebunders, Robert, and Njamnshi, Alfred K.
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- 2021
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4. Impact of 19 years of mass drug administration with ivermectin on epilepsy burden in a hyperendemic onchocerciasis area in Cameroon
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Boullé, Charlotte, Njamnshi, Alfred K., Dema, Fidèle, Mengnjo, Michel K., Siewe Fodjo, Joseph Nelson, Bissek, Anne-Cécile Zoung-Kanyi, Suykerbuyk, Patrick, Lenou-Nanga, Cédric G., Nana-Djeunga, Hugues C., Kamgno, Joseph, Chesnais, Cédric B., Boussinesq, Michel, and Colebunders, Robert
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- 2019
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5. Epilepsy in the Sanaga‐Mbam valley, an onchocerciasis‐endemic region in Cameroon: electroclinical and neuropsychological findings.
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Morin, Alexandre, Guillaume, Maxime, Ngarka, Leonard, Tatah, Godwin Y., Siewe Fodjo, Joseph Nelson, Wyart, Guillaume, Nokam, Ghislain, Tchoumi, Thierry, Nkinin, Mary Bello, Njamnshi, Wepnyu Y., Chokote, Eric‐Samuel, Boussinesq, Michel, Colebunders, Robert, Chesnais, Cédric B., Gargala, Gilles, Parain, Dominique, and Njamnshi, Alfred K.
- Abstract
Objective: Epilepsy is highly prevalent in onchocerciasis‐endemic African regions. Various types of epilepsy have been described in such regions based essentially on clinical characteristics. Methods: We conducted a clinical, neurophysiological and neuropsychological study of epilepsy in the onchocerciasis‐endemic region of Ntui, Sanaga‐Mbam area, Cameroon. Results: One hundred and eighty‐seven persons with presumed epilepsy were recruited in an epilepsy clinic in Ntui. Epilepsy was clinically confirmed in 144 (79%) subjects, 69 (46.0%) of them met the onchocerciasis‐associated epilepsy (OAE) criteria, and 51 of 106 tested (48.1%) presented Ov16 antibodies. Electroencephalograms (EEG) were recorded in 91 participants, of which 36 (33%) were considered abnormal and 27 of 36 (75%) revealed bifrontotemporal spike and slow waves. Concerning the neuropsychological evaluation, 29% showed severe global cognitive impairment, 28% severe episodic memory impairment, and 66% severe frontal cognitive impairment. Half of the persons with epilepsy (PWE) suffered from a mental disorder. Significance: In PWE in the Sanaga‐Mbam area in Cameroon, we observed EEG patterns similar to those described among persons with OAE, including nodding syndrome in other onchocerciasis‐endemic areas. Most PWE presented with severe cognitive impairment. We hypothesize that onchocerciasis may induce neurocognitive disorders and epilepsy via a mechanism that involves mainly the frontal and temporal regions of the brain. [ABSTRACT FROM AUTHOR]
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- 2021
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6. Epidemiology of epilepsy and relationship with onchocerciasis prevalence in villages of the Ntui Health District of Cameroon.
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Ngarka, Leonard, Siewe Fodjo, Joseph Nelson, Ambomatei, Calson, Njamnshi, Wepnyu Yembe, Taryunyu Njamnshi, Julius Ndi, Nfor, Leonard N., Mengnjo, Michel K., and Njamnshi, Alfred K.
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EPILEPSY , *ONCHOCERCIASIS , *PEOPLE with epilepsy , *EPIDEMIOLOGY , *VILLAGES , *ENDEMIC diseases - Abstract
• Door-to-door epilepsy surveys were conducted along the Sanaga River in Cameroon. • High epilepsy prevalence (>3% in all study villages), including nodding seizures. • Most persons with epilepsy met the criteria for onchocerciasis-associated epilepsy. • Decreasing epilepsy prevalence further away from the river (blackfly breeding site). • Effective onchocerciasis elimination measures needed to curb the epilepsy burden. A strong association between epilepsy and onchocerciasis endemicity has been reported. We sought to document the epidemiology of epilepsy in onchocerciasis-endemic villages of the Ntui Health District in Cameroon and investigate how this relates to the prevalence of onchocerciasis. In March 2022, door-to-door epilepsy surveys were conducted in four villages (Essougli, Nachtigal, Ndjame, and Ndowe). Ivermectin intake during the 2021 session of community-directed treatment with ivermectin (CDTI) was investigated in all participating village residents. Persons with epilepsy (PWE) were identified through a two-step approach: administration of a 5-item epilepsy screening questionnaire followed by clinical confirmation by a neurologist. Epilepsy findings were analyzed together with onchocerciasis epidemiological data previously obtained in the study villages. We surveyed 1663 persons in the four study villages. The 2021 CDTI coverage for all study sites was 50.9%. Overall, 67 PWE were identified (prevalence of 4.0% (IQR: 3.2–5.1) with one new-onset case during the past 12 months (annual incidence of 60.1 per 100,000 persons). The median age of PWE was 32 years (IQR: 25–40), with 41 (61.2%) being females. The majority (78.3%) of PWE met the previously published criteria for onchocerciasis-associated epilepsy (OAE). Persons with a history of nodding seizures were found in all villages and represented 19.4% of the 67 PWE. Epilepsy prevalence was positively correlated with onchocerciasis prevalence (Spearman Rho = 0.949, p = 0.051). Meanwhile, an inverse relationship was observed between distance from the Sanaga river (blackfly breeding site) and the prevalence of both epilepsy and onchocerciasis. The high epilepsy prevalence in Ntui appears to be driven by onchocerciasis. It is likely that decades of CDTI have likely contributed to a gradual decrease in epilepsy incidence, as only one new case occurred in the past year. Therefore, more effective elimination measures are urgently needed in such endemic areas to curb the OAE burden. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Epidemiology of onchocerciasis-associated epilepsy in the Mbam and Sanaga river valleys of Cameroon: impact of more than 13 years of ivermectin.
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Siewe Fodjo, Joseph Nelson, Tatah, Godwin, Tabah, Earnest Njih, Ngarka, Leonard, Nfor, Leonard Njamnshi, Chokote, Samuel Eric, Mengnjo, Michel K., Dema, Fidèle, Sitouok, Aurélien Tele, Nkoro, Grace, Ntone, Félicien E., Bissek, Anne-Cécile Zoung-Kanyi, Chesnais, Cédric B., Boussinesq, Michel, Colebunders, Robert, and Njamnshi, Alfred K.
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ONCHOCERCIASIS treatment , *IVERMECTIN , *HEALTH surveys , *EPIDEMIOLOGY - Abstract
Background: A high epilepsy prevalence has been reported in several onchocerciasis-endemic villages along the Mbam and Sanaga river valleys in Cameroon, including Bilomo and Kelleng. We sought to determine the prevalence of epilepsy in these two villages following more than 13 years of community-directed treatment with ivermectin (CDTI). Methods: Door-to-door surveys were performed on the entire resident population in the villages in August 2017 and January 2018. Epilepsy was diagnosed using a 2-step approach: administration of a standardized 5-item questionnaire followed by confirmation by a neurologist. Previously published diagnostic criteria for onchocerciasis-associated epilepsy (OAE) were used. Ov16 serology was done for children aged 7–10 years to assess onchocerciasis transmission. Findings were compared with previous data from these two villages. Results: A total of 1525 individuals (1321 in Bilomo and 204 in Kelleng) in 233 households were surveyed in both villages. The crude prevalence of epilepsy was 4.6% in Bilomo (2017) and 7.8% in Kelleng (2018), including 12 (15.6% of cases) persons with epilepsy (PWE) with nodding seizures. The age and sex-standardized prevalence in Kelleng decreased from 13.5% in 2004 to 9.3% in 2018 (P < 0.001). The median age of PWE shifted from 17 (IQR: 12–22) years to 24 (IQR: 20–30) years in Bilomo (P < 0.001); and slightly from 24 (IQR: 14–34) years to 28 (IQR: 21.25–36.75) years in Kelleng (P = 0.112). Furthermore, 47.6% of all tested children between 7 and 10 years had Ov16 antibodies. Conclusions: There is a decrease in epilepsy prevalence after 13 years and more of CDTI in both villages. The age-shift observed in PWE suggests that ivermectin may prevent OAE in younger residents. Ov16 seropositivity in children indicates ongoing onchocerciasis transmission possibly due to suboptimal control measures. Our findings support the existence of OAE in Cameroon and highlight the need to strengthen onchocerciasis elimination programs. [ABSTRACT FROM AUTHOR]
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- 2018
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