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Start Over Author "Elizabeth H. Hart" Topic calreticulin
2 results on '"Elizabeth H. Hart"'

1. In vitro biomarker discovery in the parasitic flatworm Fasciola hepatica for monitoring chemotherapeutic treatment

Author

Russell M. Morphew, Neil MacKintosh, Elizabeth H. Hart, Mark Prescott, E. James LaCourse, and Peter M. Brophy

Subjects
Proteomics, Biomarkers, Triclabendazole, Calreticulin, Genetics, QH426-470
Abstract

The parasitic flatworm Fasciola hepatica is a global food security risk. With no vaccines, the sustainability of triclabendazole (TCBZ) is threatened by emerging resistance. F. hepatica excretory/secretory (ES) products can be detected in host faeces and used to estimate TCBZ success and failure. However, there are no faecal based molecular diagnostics dedicated to assessing drug failure or resistance to TCBZ in the field. Utilising in vitro maintenance and sub-proteomic approaches two TCBZ stress ES protein response fingerprints were identified: markers of non-killing and lethal doses. This study provides candidate protein/peptide biomarkers to validate for detection of TCBZ failure and resistance.

Published
2014
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2. In vitro biomarker discovery in the parasitic flatworm Fasciola hepatica for monitoring chemotherapeutic treatment

Author

Neil Douglas MacKintosh, E. James LaCourse, Russell M. Morphew, Peter M. Brophy, Mark C. Prescott, and Elizabeth H. Hart

Subjects
Proteomics, lcsh:QH426-470, Biochemistry, qu_58.5, qx_365, Hepatica, wc_805, parasitic diseases, medicine, Fasciola hepatica, Biomarker discovery, Triclabendazole, Flatworm, wc_770, biology, biology.organism_classification, Molecular diagnostics, Virology, In vitro, lcsh:Genetics, qv_744, Immunology, Calreticulin, Biomarkers, medicine.drug
Abstract

The parasitic flatworm Fasciola hepatica is a global food security risk. With no vaccines, the sustainability of triclabendazole (TCBZ) is threatened by emerging resistance. F. hepatica excretory/secretory (ES) products can be detected in host faeces and used to estimate TCBZ success and failure. However, there are no faecal based molecular diagnostics dedicated to assessing drug failure or resistance to TCBZ in the field. Utilising in vitro maintenance and sub-proteomic approaches two TCBZ stress ES protein response fingerprints were identified: markers of non-killing and lethal doses. This study provides candidate protein/peptide biomarkers to validate for detection of TCBZ failure and resistance.

Published
2014

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