1. Fibroblast Growth Factor 23 and Matrix-Metalloproteinases in Patients with Chronic Kidney Disease: Are They Associated with Cardiovascular Disease?
- Author
-
Tomáš Zima, Jana Uhrova, Ivan Malbohan, Sylvie Dusilová-Sulková, Markéta Kratochvilová, Bandúr S, Marta Kalousová, Peiskerová M, and Tesar
- Subjects
Male ,Fibroblast growth factor 23 ,Aging ,medicine.medical_specialty ,Calcitriol ,medicine.medical_treatment ,Renal function ,Enzyme-Linked Immunosorbent Assay ,Disease ,Kidney Function Tests ,medicine.disease_cause ,Gastroenterology ,Internal medicine ,Humans ,Medicine ,Vitamin D ,Serum Albumin ,Dialysis ,Aged ,Sex Characteristics ,business.industry ,Vitamins ,General Medicine ,Middle Aged ,medicine.disease ,Lipids ,Matrix Metalloproteinases ,Fibroblast Growth Factors ,Fibroblast Growth Factor-23 ,Arterial calcification ,Endocrinology ,Cardiovascular Diseases ,Parathyroid Hormone ,Nephrology ,Disease Progression ,Cytokines ,Kidney Failure, Chronic ,Female ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers ,Oxidative stress ,Kidney disease ,medicine.drug - Abstract
Background: High cardiovascular risk in patients with chronic kidney disease (CKD) may be related to mineral disorder and microinflammation. Fibroblast growth factor 23 (FGF-23) is a phosphatonin and inhibitor of calcitriol synthesis, which is associated with poor prognosis in CKD patients starting dialysis. Matrix-metalloproteinases (MMP-2, MMP-9) contribute to myocardial remodeling and arterial calcification. FGF-23 and MMPs levels are altered in CKD, however, little is known about their association and relation to cardiovascular (CV) disease. Methods: Standard laboratory parameters, plasma levels of MMP-2, MMP-9, FGF-23, PAPP-A and CV disease history were assessed in 80 patients with CKD 1–5 and 44 healthy control subjects. Results: FGF-23 and MMP-2 (assessed by ELISA) were higher in CKD patients compared to controls. FGF-23 increased from CKD 3, whereas MMP-2 increased only in CKD 5. FGF-23 was positively associated with MMP-2, adjusted to age, eGFR, phosphatemia, calcitriol and parathormone. FGF-23 independently correlated with parathormone and inversely with calcitriol, whereas MMP-2 was related to phosphatemia. FGF-23 was higher in subjects with a history of CV disease compared to those free of such history (559.0 vs.184.0 RU/ml), adjusted to age and eGFR. Conclusion: Our data suggest a possible relationship between FGF-23, MMP-2 and CV disease in CKD. Potential causality of this association remains to be elucidated.
- Published
- 2009
- Full Text
- View/download PDF