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Objective: This study aimed to determine the correlation between pentraxin-3 and procalcitonin levels with Sequential Organ Failure Assessment (SOFA) scores in septic patients. Design: This observational analysis with a cross-sectional method assessed the correlation between pentraxin-3 (PTX-3) and procalcitonin (PCT) levels and the SOFA scores of septic patients. Setting: We conducted this study in the Intensive Care Unit (ICU) of Dr. Wahidin Sudirohusodo Hospital and Medical Laboratory Center of Hasanuddin University from December 2023 to April 2024. Patients and participants: Thirty-two patients with clinical sepsis were admitted to the ICU of Dr. Wahidin Sudirohusodo Hospital. Intervention: Blood samples were collected on day 1 and day 2 of ICU care in septic patients to measure pentraxin-3 and procalcitonin levels. Measurements and results: The Wilcoxon test showed a significant difference in pentraxin-3 levels on ICU care's first and second days (p=0.036). Similarly, there was a significant difference in procalcitonin levels on the first and second days of ICU care. The Spearman correlation test found a significant correlation between procalcitonin and SOFA scores (p=0.008) with a correlation value r=0.462 on the first and second days. The resulting correlation value showed a positive correlation, which meant that the higher the procalcitonin level in septic patients, the higher the SOFA scores with moderate strength (correlation value 0.4-<0.6). The correlation of pentraxin- 3 with the Spearman test showed a positive correlation on the first day. In contrast, on the second day, there was no significant statistical value with the SOFA scores with a correlation value p=0.093 (p>0.05). Conclusion: Pentraxin-3 and procalcitonin levels correlate with SOFA scores in septic patients admitted to the ICU. [ABSTRACT FROM AUTHOR]