1. Pseudoxanthoma elasticum-like changes in nonuremic calciphylaxis: Case series and brief review of a helpful diagnostic clue.
- Author
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Nathoo RK, Harb JN, Auerbach J, Guo R, Vincek V, and Motaparthi K
- Subjects
- Aged, 80 and over, Biopsy, Blood Vessels pathology, Calciphylaxis complications, Diagnosis, Differential, Elastic Tissue pathology, Female, Humans, Leukemia, Lymphocytic, Chronic, B-Cell complications, Leukemia, Lymphocytic, Chronic, B-Cell drug therapy, Middle Aged, Pseudoxanthoma Elasticum complications, Calciphylaxis pathology, Kidney Failure, Chronic complications, Leg Ulcer pathology, Leukemia, Lymphocytic, Chronic, B-Cell pathology, Pseudoxanthoma Elasticum pathology
- Abstract
Calciphylaxis is a rare syndrome of vascular calcification with thrombosis that occurs most often in patients with end-stage renal disease, and it frequently portends a guarded prognosis. Rarely, nonuremic calciphylaxis (NUC) may occur; in this context, a strongly supportive histology is crucial in establishing the diagnosis. Herein, we describe 2 cases of NUC associated with pseudoxanthoma elasticum-like changes, identified in both initial nondiagnostic and subsequent diagnostic biopsy specimens. This unusual but helpful histologic finding may support the early diagnosis and treatment of a potentially life-threatening disease in the context of subtle histopathologic vascular changes or in the absence of classic clinical or laboratory findings., (© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2017
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