1. Effect of prophylactic caffeine in the treatment of apnea in very low birth weight infants: a meta-analysis.
- Author
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Miao Y, Liu W, Zhao S, Li Y, Jiang H, Wang A, Teng P, and Zhang Y
- Subjects
- Humans, Infant, Newborn, Infant, Premature, Infant, Very Low Birth Weight, Respiration, Artificial, Apnea prevention & control, Caffeine therapeutic use
- Abstract
Objective: The purpose of this meta-analysis is to investigate the effect of prophylactic caffeine use in the treatment of apnea and other clinical outcomes in very low birth weight infants., Methods: We searched PubMed, Embase, Web of Science, Scopus, EBSCO, CNKI, and Cochrane databases for all relevant studies up to May 20, 2022. The meta-analysis was carried out using Stata16.0 and RevMan5.4 software., Results: Eleven randomized controlled trials were evaluated, including a total of 4375 very low birth weight infants. The results demonstrated that prophylactic caffeine use was linked with a significantly lower probability of AOP (OR 0.31, 95% CI: 0.19-0.49, p < .001), duration of mechanical ventilation and oxygen therapy when compared to the control group. It also reduced the incidence of BPD (OR 0.62, 95% CI: 0.54-0.71, p < .001), PDA (OR 0.49, 95% CI: 0.30-0.80, p = .005) and ROP (OR 0.76, 95% CI: 0.65-0.90, p = .001), without raising the risk of NEC, IVH and death before hospital discharge ( p > .05)., Conclusion: This meta-analysis confirmed the beneficial effects of prophylactic caffeine in preventing apnea of prematurity and improving clinical outcomes.
- Published
- 2023
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