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1. Macrocyclic polyesters. I. A novel class of 1,3-butandiol derivatives as potential antimicrobial agents.

Author

Fadda AM, Maccioni AM, Maccioni E, and Podda G

Subjects
Anti-Bacterial Agents, Antifungal Agents chemical synthesis, Antifungal Agents pharmacology, Butylene Glycols pharmacology, Candida albicans drug effects, Escherichia coli drug effects, Microbial Sensitivity Tests, Staphylococcus aureus drug effects, Anti-Infective Agents chemical synthesis, Butylene Glycols chemical synthesis
Abstract

This paper reports the synthesis of a novel class of macrocyclic tetraesters containing 1,3-butandiol sub-units by reacting the stannolan derivative of the diol with diacyl chloride. The structure of the possible isomers was assigned by spectroscopic data and comparison with samples otherwise prepared. Preliminary screening revealed that these compounds have low antimicrobial activity, although it is higher than that of the starting diol.

Published
1992

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