1. Diagnosing Pulmonary Tuberculosis by Using Sequence-Specific Purification of Urine Cell-Free DNA
- Author
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Zinhle Ngcobo, M. William Ngwane, Paul K. Drain, Zanele P. Magcaba, Douglas Wilson, David J. Horne, Diana Marangu, Barry R. Lutz, Amy Oreskovic, Nuttada Panpradist, Sindiswa Ngcobo, and Adrienne E Shapiro
- Subjects
Microbiology (medical) ,medicine.medical_specialty ,Tuberculosis ,DNA purification ,DNA hybridization ,HIV Infections ,Urine ,Gastroenterology ,Sensitivity and Specificity ,Cohort Studies ,cell-free DNA ,South Africa ,Pulmonary tuberculosis ,Internal medicine ,diagnostics ,Medicine ,Humans ,Tuberculosis, Pulmonary ,Lipoarabinomannan ,sample preparation ,business.industry ,Sputum ,Mycobacteriology and Aerobic Actinomycetes ,Mycobacterium tuberculosis ,medicine.disease ,DNA extraction ,urine ,PCR ,Cell-free fetal DNA ,tuberculosis ,Biomarker (medicine) ,medicine.symptom ,business ,Cell-Free Nucleic Acids ,transrenal DNA - Abstract
Transrenal urine cell-free DNA (cfDNA) is a promising tuberculosis (TB) biomarker, but is challenging to detect because of the short length (
- Published
- 2021