1. Cytokine-induced killer cells in the treatment of patients with solid carcinomas: a systematic review and pooled analysis
- Author
-
Lei Tang, Yue Ma, Zan Zhang, Ying-Chun Xu, Hong-Xia Wang, Xiao Feng Gu, and Zhi-Ming Xie
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,Immunology ,Cell ,Cell- and Tissue-Based Therapy ,Cell therapy ,Cytokine-Induced Killer Cells ,Internal medicine ,medicine ,Humans ,Immunology and Allergy ,Adverse effect ,Genetics (clinical) ,Transplantation ,Cytokine-induced killer cell ,business.industry ,Carcinoma ,Cancer ,Cell Biology ,medicine.disease ,Clinical trial ,medicine.anatomical_structure ,Pooled analysis ,Meta-analysis ,business - Abstract
The aim of this study was to evaluate the efficacy and safety of cytokine-induced killer (CIK) cell therapy for solid carcinomas.We performed a computerized search of phase II/III clinical trial databases of CIK cell-based therapy using a combination of the terms 'cytokine-induced killer cells', 'tumor' and 'cancer'.Treatment with CIK cells was associated with a significantly improved half-year survival (P = 0.003), 1-year survival (P = 0.0005), 2-year survival (P0.01) and mean survival time (MST) (P0.001). Patients in the CIK group showed a prolonged half-year progression-free survival (PFS) (P0.01), 1-year PFS (P0.01) and median time to progression (MTTP) (P0.001). A favored disease control rate (DCR) was observed in patients receiving CIK cell therapy, while the objective response rate (ORR) was not altered (P = 0.05) compared with the non-CIK group (P = 0.007). CIK cell therapy could also reduce the adverse effects of grade III and IV leukopenia caused by chemotherapy (P = 0.002) and diminish hepatitis B virus (HBV)-DNA content (P0.01). However, the incidence of fever in the CIK therapy group was significantly higher than in the non-CIK group (P = 0.02). The percentage of CD3(+), CD4(+), CD4(+)CD8(+), CD3(-) CD56(+) and CD3(+) CD56(+) T-lymphocyte subsets in the peripheral blood of cancer patients was significantly increased, whereas the percentage of CD8(+) T-lymphocyte cells was significantly decreased in the CIK group compared with the non-CIK group (P0.01).CIK cell therapy has demonstrated a significant superiority in prolonging the MST, PFS, DCR and quality of life (QoL) of patients.
- Published
- 2012
- Full Text
- View/download PDF