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Most of the current tracking methods use bounding box to describe objects, which only provides a rough outline and is unable to accurately capture the shape and posture of the target. Instead of using a bounding box directly, we use points adaptively positioned on the target to describe the target and transform these points to bounding boxes. In this way, we can use a training strategy based on bounding box while describing the target more accurately. Furthermore, a Coarse-Fine classification module is employed to improve the robustness, which is important in the case of scale variation and deformation. Combining the above modules, we propose our SiamPCF, which is an anchor-free tracking method that avoids the carefully selected hyperparameters needed to design anchors. Extensive experiments conducted on five benchmarks show that our SiamPCF can achieve state-of-the-art results. In the analysis of video attributes, our SiamPCF ranks first in scale variance, which demonstrates its effectiveness. Our SiamPCF runs more than 45 frames per second.

To clarify which one has a different predominance of Th1 and Th2 immune responses in malignant and tuberculous pleural effusions. We did a meta-analysis of the results published previously to assess the levels of Th1/Th2 cytokines in two types of pleural effusion, and evaluated its ability to distinguish TPE from MPE. We queried the PubMed and Embase databases for studies indexed from 2000 up to March 2021. We included studies that (a) diagnosis of TPE and MPE by on culture, or pleural biopsy tissue provided; (b) compared levels of Th1/Th2 cytokines in pleural effusion between TPE and MPE. Pooled data by using a random-effects model or fixed-effects model, standardized mean differences (SMD) across studies comparing TPE and MPE. We also performed Egger test to assess of publication bias. Of 917 identified studies, a total of 42 studies were selected in the meta-analysis. Compared with malignant subjects, tuberculous subjects had a significant higher level of TNF-α [2.22, (1.60–2.84)], an elevated level of IFN-γ [3.30, (2.57–4.40)] in pleural effusion, a situation where the Th1 immune response dominates. Conversely, Interleukin-4 (IL-4) and IL-10 (Th2 cytokines) levels were higher in MPE than TPE. Besides, they were shown to be statistically insignificant tiny effects were [-0.15, (-0.94–0.63)], [-0.04, (-0.21–0.12)] respectively. We confirmed that pleural effusions caused by tuberculosis, a situation in which the Th1 cytokines are predominant. The slight preponderance of Th2 cytokines in malignant pleural effusions, which are not convincing enough to prove.