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This study investigated the effects of acute and chronic administration of the non-competitive NMDA receptor antagonists MK-801 on c-Fos protein expression in different brain regions of mice with or without clozapine. MK-801 (0.6 mg/kg) acute administration produced a significant increase in the expression of c-Fos protein in the layers III-IV of posterior cingulate and retrosplenial (PC/RS) cortex, which was consistent with the previous reports. Moreover, we presented a new finding that MK-801 (0.6 mg/kg) chronic administration for 8 days produced a significant increase of c-Fos protein expression in the PC/RS cortex, prefrontal cortex (PFC) and hypothalamus of mice. Among that, c-Fos protein expression in the PC/RS cortex of mice was most significant. Compared to acute administration, we found that MK-801 chronic administration significantly increased the expression of c-Fos protein in the PC/RS cortex, PFC and hypothalamus. Furthermore, pretreatment of mice with clozapine significantly decreased the expression of c-Fos protein induced by MK-801 acute and chronic administration. These results suggest that c-Fos protein, the marker of neuronal activation, might play an important role in the chronic pathophysiological process of schizophrenic model induced by NMDA receptor antagonist.

Quantitative evaluation of service quality is very important in modern service industry, so there has important theoretical and practical significance of studying comprehensive evaluation method of customer satisfaction. This paper discusses customer satisfaction concept and constructs evaluation index system for customer satisfaction oriented information service, then describes the theories and procedures of TOPSIS evaluation method and entropy weighted method. Finally, this paper takes university library-a typical kind of information service industry for example, using TOPSIS method to evaluate the library's reader satisfaction, discusses the evaluation results and gives suggestions for improving its information service quality and level based on the results.

This paper systematically analyzed specialized market's demands and business models of E-Commerce, made a research on the construction of E-Commerce platform for specialized market, and presented the general system structure. On this basis, a modular and integrate function structure was proposed by structural system design. Finally we used a specific case to provide a feasible solution for the development of E-Commerce platform for specialized market.

Through the requirement analysis of hospital management, the paper elaborates the necessity and feasibility of hospital informatization from the traditional information management to knowledge management based on the hospital information system (HIS hereafter). With the discussion of knowledge management mechanisms and characteristics of Wiki, a Wiki & HIS-based application mode of hospital knowledge management is put forward with a case of the clinician combined with his practical application. This solution can organically match the e-commerce service mode and the techniques of Web2.0 to the requirement of hospital knowledge management, and is helpful to construct the new dynamic, open, distributed and service-oriented hospital information system.

The main role of E-Business in the information revolution concentrates on reconstructing and optimizing the traditional business model and the mechanism of value-creating. With the development of the industry information, many types of e-markets have been emerging, and E-exchange is just one of them. On the background of Guangdong Plastics Exchange’s practical program construction, the article summarizes and analyses the concept and characters of E-exchange on the basic of the construction of the plastics exchange e-market, and describes all its functions, as well as opens out the business model and operation mechanism. Finally, it points out that developing and constructing staple commodity exchange e-markets that orient to different industries, would be an important prospect of the industry information in future in China.

This paper carried on an analysis to the knowledge management requirements of learning organizations. Based on the requirements and the knowledge management methods, a new knowledge management solution on the learning organizations has been proposed, and the functions of the new solution have been pointed out concretely.

To evaluate exactly the performance of knowledge management (KM) is an important part of the construction of enterprise knowledge management systems. Based on enterprise capital, a performance evaluation index system has designed by using intellectual capital, organization capital and market capital as subjects in this paper. In order to realize quantitative calculation for qualitative index, a fuzzy calculation method, that is triangular fuzzy number (TFN) evaluation method is proposed. Then the method’s theory and steps are discussed. Finally, the empirical study has been done on three IT enterprises, use TFN method to evaluate their KM performance, and some improvement suggestions are given based on evaluation results.

Knowledge management (KM) is a new problem for e- commerce and enterprise application integration (EAI) , and it has become one of the research front and hotspots in management science and engineering. In this paper, the requirements and key problems of e-commerce application oriented enterprise KM are discussed, a enterprise information portal(EIP) based KM solution is presented, the key techniques for implementation are pointed. At last, a case of Midea is studied, in addition, the developing trends and foreground of KM are discussed also.

As an important part of knowledge management (KM), the KM performance evaluation tries to find out the key factors restraining the enhancement of the enterprises' performance. In this paper, some primary factors of the performance of enterprises KM are analyzed and an index system of KM performance is established by considering some aspects, such as marketing capability, information management, maturity degree of the learning organizations, and knowledge stocks. A principal component analysis and the arithmetic steps for principal component analysis are presented to evaluate the KM performance. The case analysis shows that the principal component analysis method is efficient and practical for the KM performance evaluation.

Dispute about conception and research area of knowledge management exists always. In order to distinguish and evaluate about the influence factor of the success or failure of knowledge management project, it is necessary to understand it in the point of system thought and to design an integrated entirely knowledge management framework model that is accepted at large. Firstly, this article starts with the research on the present knowledge management and the analysis of different views, discussing the system framework, connotation and extension of knowledge management with systemic viewpoint. Then the paper will develop a knowledge management framework model and propose a system framework of knowledge management system and its practical application.

As the reform development of telecom industry and the entrance of WTO, the competition among the telecom enterprises is becoming tougher. Nowadays, "customer-oriented" is the new principle of telecom market competition. As the enterprises in telecom industry have much more customers and customer data than those in other industries, the application of customer relationship management (CRM) in telecom industry becomes one of the hottest topics on enterprise informationlization. The thesis discusses the discovery of telecom customer knowledge based on data-mining. In this paper, a customer analysis model is founded by the method of data mining, including customer segmentation analysis, customer churn analysis, customer owing and fraud analysis. In the end, the thesis introduces a real case of a customer segmentation project in a mobile communication company and illustrates the application detail of customer intelligence in this company. In this case, the author uses SPSS Clementine to conduct data-mining. Meanwhile, diverse marketing strategy is also proposed based on the customer segmentation knowledge.

Knowledge management (KM) system includes KM strategic planning, technique, culture foundation, knowledge resource, process of knowledge transformation and exterior circumstance. Whether the definitude of KM stratagem or the early requirement design of KM implement, it must to evaluate the KM performance, to audit the KM requirement and program and to fulfill the KM process positive and feedback closed loop system. Organizations can set down KM strategy and programming and implement effectively no other than understanding its own knowledge stock, processes and requirement; can optimize KM no other than timely evaluating and auditing KM. This article introduce the concept of knowledge capital which root in intellectual capital as the object of the knowledge audit, thus the research fruit of intellectual capital could be used to study knowledge audit. Based on that, this article put forwards the integrity conception of KM audit, constitutes a conception model of knowledge audit and presents the workflow and currently methods of implementing knowledge audit.

With the development of information system, there is an urgent need for enterprises to change from information management to knowledge management. In the network-computing environment, enterprises need to apply the complex, dynamic and integrated, object-oriented knowledge management system. First, this paper analyzed the essence of knowledge and knowledge management, discussed the concept and characteristics of enterprise knowledge portal. On this basis, the article proposed a management object oriented solution of knowledge management system, focusing on the framework of the system, mode of operation and the value of application with a case study. Such a solution can help enterprises to establish open, dynamic and integrated information and knowledge management systems.

The VCM (Vector-Correlative Model) is one of the currently popular models for information searching. In this paper, author inducted Fuzzy Sets theory and approach for to construct information searching models, and presented a new VCM, which is called Fuzzy Vector-correlative Model (FVCM). So, its theory structure and user's searching quizzing mode has been dimming improved. We have show with some fringe experimentation that the new model has overcome some intrinsic defects of the exciting ones, and has raised the precision and recall of information search system.