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There is an urgent need to apply basic research achievements to the clinic. In particular, mechanistic studies should be developed by bench researchers, depending upon clinical demands, in order to improve the survival and quality of life of cancer patients. To date, translational medicine has been addressed in cancer biology, particularly in the identification and characterization of novel tumor biomarkers. This review focuses on the recent achievements and clinical application prospects in tumor biomarkers based on translational medicine.

We examine two-photon selective reflection (SR) spectroscopy in a system of -type three-level atoms at the interface with a ferroelectric layer on a dielectric surface. Two-photon SR lines, exhibiting Dicke-narrowing profiles due to atom-wall collision and Doppler free configuration, are periodically modulated by the thickness of the atomic vapor. These SR lines can be modified by the thickness and the complex refractive index of the ferroelectric layer, and can probably be a feasible method used in the measurement of the optical parameters of the ferroelectric layer.

We theoretically examine thickness and wavelength dependence line-shape of four-wave-mixing (FWM) spectroscopy in micrometric thin atomic vapors whose thickness L is assumed to be 10,30,50,80and 100 µm respectively. It is found that a nar- row centre (Dicke-narrowing) persists for all cases, while wings are broadened as the thickness of the vapor increases or the pump wavelength decreases comparing to the probe wavelength. This type of spectrum is due to the modified velocity distribution and polarization interference from different ensemble of atoms in a confined situation.

We examine selective reflection (SR) spectrum of an Airy beam at an interface between a dielectric and a homogeneous atomic medium. It is shown that both the general reflection (GR) and the SR of Airy beams exhibit accelerating dynamics with a parabolic trajectory, however, the accelerating rate for the SR is slightly greater than that for the GR. Due to interaction of atoms and the Airy beams at the interface between dielectric and resonant atoms, the SR beams can create far-field interference patterns. We also show that the amplitude of the SR can be dramatically modified by the detuning of the incident fields, the reduced x-coordinate and the distance from the interface. The SR at the resonant medium interface of Airy beams can probably be a powerful tool in the use of optical power delivering, resonant particle manipulation and spatial spectrum detection of a resonant medium at an interface.