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Ambient concentrations of volatile organic compounds (VOCs) vary with emission rates, meteorology, and chemistry. Conventional positive matrix factorization (PMF) loses information because of dilution variations and chemical losses. Multiply improved PMF incorporates the ventilation coefficient, and total solar radiation or oxidants to reduce the effects of dispersion and chemical loss. These methods were applied to hourly speciated VOC data from November 2019 to March 2020 including during the COVID-19 shutdown. Various comparisons were made to assess the influences of these fluctuation drivers by time of day. Dispersion normalized PMF (DN-PMF) reduced the dispersion variations. Dispersion-radiation normalized PMF (DRN-PMF) reduced the impact of chemical loss, especially at night, which was better than Dispersion-Ox normalized PMF (DON-PMF). The conditional bivariate probability function (CBPF) plots of DRN-PMF results were consist with actual source locations. The DN-PMF, DRN-PMF, and DON-PMF results were consistent between 10:00 and 15:00, suggesting dispersion was significantly more influential than photochemical reactions during these times. The DRN-PMF results indicated that the highest VOC contributors during the COVID-19 shutdown were liquefied petroleum gas (LPG) (28.8%), natural gas (25.2%), and pulverized coal boilers emissions (19.6%). Except for petrochemical-related enterprises and LPG, the contribution concentrations of all other sources decreased substantially during the COVID-19 shutdown, by 94.7%, 90.6%, and 86.8% for vehicle emissions, gasoline evaporation, and the mixed source of diesel evaporation and solvent use, respectively. Controlling the use of motor vehicles and related volatilization of diesel fuel and gasoline can be effective in controlling VOCs in the future.

The purpose of this study was to investigate the effects of dietary Selenohomolanthionine (SeHLan) on antioxidant status and immune response in canine parvovirus (CPV) vaccinated puppies. In this study, 30 weaned puppies were randomly divided into six groups: control group (–Se/–Vacc), immunization group (–Se/+Vacc), supplementation of sodium selenite group (SS/+Vacc, 0.35 mg/kg DM), low-dose SeHLan group (SeHLan-L/+Vacc, 0.35 mg/kg DM), mid-dose SeHLan group (SeHLan-M/+Vacc, 1.0 mg/kg DM), and high-dose SeHLan group (SeHLan-H/+Vacc, 2.0 mg/kg DM). The puppies were fed for 42 days and vaccinated with Vanguard Plus 5 on day 0 and day 21. Blood samples were collected on 7, 14, 21, 28, 35, 42 days post-immunization (PI) for determination of antioxidant indicators, lymphocyte proliferation index, serum cytokine concentration (IL-2, IL-4), canine polymorphonuclear neutrophils (PMN) phagocytic function, and the level of CPV antibody titers. The results showed that SeHLan supplementation raised the serum Se concentration and glutathione peroxidase (GSH-Px) activity in a dose-dependent manner (P < 0.05). It also increased the activity of serum superoxide dismutase (SOD) and decreased serum malondialdehyde (MDA) content, especially in SeHLan-M/+Vacc group (1.0 mg/kg DM) (P < 0.01). SeHLan supplementation significantly increased lymphocyte proliferation, IL-2, and IL-4 levels in canine serum, and enhanced phagocytosis of PMN in vaccinated puppies (P < 0.05). Moreover, SeHLan supplementation shortened the CPV antibody production time and increased the CPV antibody titers (P < 0.05). Of note, the beneficial effects of SeHLan were superior to those of SS. In conclusion, dietary SeHLan supplementation improved antioxidant activity, increased CPV antibody titers, and enhanced immune function in puppies after weaning. An appropriate dosage of SeHLan (1~2 mg/kg DM) may confer nutritional benefits in puppies.

To characterize the spatial patterns of functional connectivity(FC) changes of whole brain in RRMS with somatosensory disorder(RRMS-SS) and to investigate the correlation between abnormal FC and clinical scores.Twenty-six RRMS-SS patients and 23 healthy controls(HC) underwent resting-state functional magnetic resonance imaging(RS-fMRI) scanning. The clinical scores were collected including Expanded Disability Status Scores(EDSS), Disease Duration and Somatosensory Evaluation by the Fugl-Meyer sensory score(FMSS). With the voxel-wise methods, RS-fMRI data were analyzed using REST software, to assess the FC of the postcentral gyrus(PoCG). Correlation between clinical variables and the strength of FC was analyzed.Compared with HC, the left postcentral-based FC showed decreased FC of the right cerebellum_8, lingual lobe and Rolandic operculum gyrus, and increased FC of the left middle frontal lobe. The right postcentral-based FC revealed decreased FC with the right Heschl's gyrus lobule, and increased FC with bilateral middle frontal lobe (p 0.001, AlphaSim corrected). Correlation analysis revealed that the FC of altered brain regions was associated with FMSS, EDSS and disease duration.The functional connectivity of PoCG at RS-fMRI has multi-network changes in patients with RRMS-SS. This suggests a complex pattern of abnormal connections between the somatosensory network regions and the whole brain. Moreover, the correlation between the FC and the FMSS, such as the left middle frontal lobe and the right PoCG, indicate that these two brain regions play an important role in RRMS-SS.

As the third-largest natural gas consumption market, natural gas is of great significance to the economic growth and structure of China. The promotion of natural gas will greatly change the production in every industry directly or indirectly. Based on the modified Cobb-Douglas function, this paper established the panel data from 30 provinces of 2000–2014 to study the relationship through panel quantile regression. The panel quantile results proved that the higher level of economy, the greater the marginal effect of natural gas is on economic growth; then considering the different economy scale of provinces, the panel data is divided into three groups, the results have drawn the same conclusion. Thus, measures to develop natural gas and reform gas market have been put forward, including deepening market-oriented reform of natural gas system, perfecting the construction and management of pipeline transportation and encouraging the consumption of natural gas.

EPICS (experimental physics and industrial control system) is an open source, cross platform, distributed real-time control framework, which is widely used to control devices such as particle accelerators, large-scale experiments, large telescopes and other large-scale experiments. In the telescope control system, it is necessary to meet the real-time and distributed control requirements. For the distributed telescope observation and control system RACS2 (Remote Autonomous Control System), it can be divided into three layers: user interface layer, observation control layer and equipment control layer. This paper mainly discusses the content related to the device control layer, which is mainly used to control the equipment of a telescope. We use EPICS framework to realize the unified control of telescope, camera, dome, weather station and other equipment. The device control layer of RACS2 realizes the conversion from EPICS protocol to RACS2 protocol through EPICSBridge module, so users can control the devices through RACS2.

Background: The expression of non-coding RNAs were closely related to breast cancer progression. However, there were no systemic analysis of non-coding RNAs in breast cancer diagnosis of the blood circulatory system. Herein, we aimed to collect all the evidence to test the potential role of non-coding RNAs as novel biomarkers in human breast cancers. Methods: A comprehensive search strategy was used to search relevant literatures in the Web of Science, PubMed, and Embase databases from January 2012 to November 2019. The correlation of non-coding RNAs expression in serum, plasma or blood circulatory system and the diagnostic accuracy of BC markers were analyzed. The methodological quality of each study was assessed using the QUADAS-2. Statistical analysis was used the STATA (version 12.0), Meta-Disc (version 1.4) and Review Manager (version 5.3) software. Results: The present meta-analysis of the non-coding RNAs expression data of BC patients and healthy specimens’ bloodfrom 2392 patients in 24 publications (32 studies). The pooled sensitivity, specificity, and AUC values were 0.82, 0.83, and 0.89, respectively. Subgroup analyses showed that the expression of non-coding RNA (miRNA, circRNA, andlncRNA) in the blood circulatory system (including blood, plasma, and serum) of BC was more prone to be detected in TNM stage and subtype of BC group, with a high value of the sensitivity and AUC. Conclusions: The blood circulatory system (including blood, plasma, and serum) of miRNAs, circRNAs, and lncRNAs detection may be effective for diagnosing breast cancer, particularly in TNM stage, subtype of BC (ER/PgR, PR or HER2/c-erbB-2) group of breast cancer. Further studies are needed to identify the value of these non-coding RNAs as novel markers in clinical.

In recent years, with the rapid development of Internet technology, all walks of life in our country are in the stage of rapid development, and tourism is constantly rising. Hostel and lodging is an important area in the development of the tourism industry. It is growing rapidly in the core areas of tourism. Because of the increasing demand of people, how to improve the competitiveness of hotel and lodging and promote the future development of hotel and lodging is the top priority of tourism industry. This article mainly carries on the simple investigation to the current situation of the development of the homestay in the background of “Internet +”, and discusses a series of problems existing in the development of the current homestay. Then, it puts forward corresponding suggestions and strategies for the future development of the residential quarters according to the relevant departments, hoping to further enhance the competitiveness of the home and Hostel, and promote the tourism industry. The development of industry enriches people’s spiritual and cultural life.

The liberalization and openness of the “Belt and Road” strategy have brought new opportunities for trade development to China and its countries along the route. Since the initiative of General Secretary Xi Jinping in September 2013 proposed the “Silk Road Economic Belt,” the level of trade facilitation in the countries along the “Belt and Road” has changed to varying degrees, in order to promote economic development and reduce trade between China and countries along the route. Cost should be in line with the development of the times, compare the level of cross-border e-commerce facilitation and analyze how to promote the rational development of China’s trade layout. This paper first analyzes the construction of the trade facilitation index system, then studies the cross-border e-commerce facilitation between countries, analyzes the impact on China’s trade layout, and finally proposes countermeasures to promote the trade development between China and the countries along the “Belt and Road” in order to communicate with relevant parties.

Background To examine the clinical value of miR-198-5p in lung squamous cell carcinoma (LUSC). Methods Gene Expression Omnibus (GEO) microarray datasets were used to explore the miR-198-5p expression and its diagnostic value in LUSC. Real-time reverse transcription quantitative polymerase chain reaction was used to evaluate the expression of miR-198-5p in 23 formalin-fixed, paraffin-embedded (FFPE) LUSC tissues and corresponding non-cancerous tissues. The correlation between miR-198-5p expression and clinic pathological features was assessed. Meanwhile, putative target messenger RNAs of miR-198-5p were identified based on the analysis of differentially expressed genes in the Cancer Genome Atlas (TCGA) and 12 miRNA prediction tools. Subsequently, the putative target genes were sent to Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses. Results MiR-198-5p was low expressed in LUSC tissues. The combined standard mean difference (SMD) values of miR-198-5p expression based on GEO datasets were − 0.30 (95% confidence interval (CI) − 0.54, − 0.06) and − 0.39 (95% CI − 0.83, 0.05) using fixed effect model and random effect model, respectively. The sensitivity and specificity were not sufficiently high, as the area under the curve (AUC) was 0.7749 (Q* = 0.7143) based on summarized receiver operating characteristic (SROC) curves constructed using GEO datasets. Based on the in-house RT-qPCR, miR-198-5p expression was 4.3826 ± 1.7660 in LUSC tissues and 4.4522 ± 1.8263 in adjacent normal tissues (P = 0.885). The expression of miR-198-5p was significantly higher in patients with early TNM stages (I-II) than that in cases with advanced TNM stages (III-IV) (5.4400 ± 1.5277 vs 3.5690 ± 1.5228, P = 0.008). Continuous variable-based meta-analysis of GEO and PCR data displayed the SMD values of − 0.26 (95% CI − 0.48, − 0.04) and − 0.34 (95% CI − 0.71, 0.04) based on fixed and random effect models, respectively. As for the diagnostic value of miR-198-5p, the AUC based on the SROC curve using GEO and PCR data was 0.7351 (Q* = 0.6812). In total, 542 genes were identified as the targets of miR-198-5p. The most enriched Gene Ontology terms were epidermis development among biological processes, cell junction among cellular components, and protein dimerization activity among molecule functions. The pathway of non-small cell lung cancer was the most significant pathway identified using Kyoto Encyclopedia of Genes and Genomes analysis. Conclusion The expression of miR-198-5p is related to the TNM stage. Thus, miR-198-5p might play an important role via its target genes in LUSC.

Three new type of single crystallite PbBiO 2 X (X = Cl, Br and I) square-like nanoplates with several hundreds nanometers in length are synthesized via a simple hydrothermal method. The band structure and hehavior of charge carriers for the nanoplates are investigated experimentally and theoretically. The halogen elements are closely related to the indirect narrow band gap(2.61 eV, 2.51 eV and 2.38 eV for PbBiO 2 Cl, PbBiO 2 Br and PbBiO 2 I, respectively). The PbBiO 2 X square-like nanoplates exhibit improved photocatalytic performance on degradation of organic pollutant under visible irradiation, owing to their novel nanostructure and efficient photoelectric conversion. This work demonstrates that PbBiO 2 X nanoplates can be considered as a promising photocatalyst and offer a better understanding about other halogen group elements related semiconductors.

Objective To investigate the pathological features of fatal pediatric hand foot and mouth disease (HFMD). Methods The histopathological features of HFMD were first summarized from literature, and then confirmed by in-house autopsies. Furthermore, immunohistochemistry was conducted to detect the distribution and expression level of two enterovirus 71 (EV71) receptors scavenger receptor class B, member 2 (SCARB2), and P-selectin glycoprotein ligand-1 (PSGL1) in the samples of autopsies. Results The main symptoms of HFMD included hand and foot rashes, as well as oral herpes. The fatal HFMD patients had typical histopathological change in the central nervous system, such as encephaledema and encephalitis. As for respiratory system, the fatal HFMD patients suffered acute pulmonary edema and congestion. SCARB2 positive signaling was distributed equally in bronchial and bronchiolar epithelial cells, alveolar epithelial cells and inflammatory cells of all HFMD patients, healthy children and adults without significant difference. PSGL-1 dispersed in bronchial and bronchiolar epithelial cells of healthy adults, but no PSGL-1 expression was detected in HFMD patients and healthy children. Conclusions Both of the central nervous and respiratory systems may be involved in the fatal HFMD patients. The EV71 receptor PSGL-1 might play essential parts in the pathogenesis of fatal HFMD, however, the hypothesis needs to be further investigated.

Due to instant availability of data on social media platforms like Twitter, and advances in machine learning and data management technology, real-time crisis informatics has emerged as a prolific research area in the last decade. Although several benchmarks are now available, especially on portals like CrisisLex, an important, practical problem that has not been addressed thus far is the rapid acquisition, benchmarking and visual exploration of data from free, publicly available streams like the Twitter API in the immediate aftermath of a crisis. In this paper, we present such a pipeline for facilitating immediate post-crisis data collection, curation and relevance filtering from the Twitter API. The pipeline is minimally supervised, alleviating the need for feature engineering by including a judicious mix of data preprocessing and fast text embeddings, along with an active learning framework. We illustrate the utility of the pipeline by describing a recent case study wherein it was used to collect and analyze millions of tweets in the immediate aftermath of the Las Vegas shootings in 2017.

With the development of society and Internet information, the society has gradually become an information age. In the background of the information age, the correlation and competition between computer information services and international trade have become increasingly prominent. Through the changes of MS index, TC index and CA index, this paper mainly analyzes the connection and competition between computer information services and international trade.

BACKGROUND Bladder carcinoma (BLCA) is a leading cause of cancer-related deaths worldwide. The aim of this work was to develop an accurate stratification in predicting the prognosis and directing the treatment of BLCA patients based on small nucleolar RNAs (snoRNAs). MATERIAL AND METHODS Expression profiles of snoRNAs were downloaded from the SNORic database. The expression profiles and clinical outcomes of BLCA patients were analyzed. Survival-associated snoRNAs were identified and used to develop a novel risk score classifier. Genes in the whole genome that were significantly correlated with the included prognostic snoRNAs were used for functional enrichment analysis. RESULTS The results showed that age, American Joint Committee on Cancer (AJCC) stage, and tumor status were significantly correlated with overall survival (OS) of BLCA patients. We selected 12 survival-associated snoRNAs to build a prognostic signature. Patients were separated into high- and low-risk groups based on the median value of the risk score. Patients in the high-risk group and low-risk group have distinct clinical outcomes. The AJCC TNM stage showed moderate utility as a prognostic indicator for clinical outcome prediction. Then, clinical parameters and risk scores were entered in multivariate Cox analysis. Notably, the prognostic signature remained an independent significant prognostic risk factor. The pathway analysis suggested that these genes were enriched in several types of cancer and "Focal adhesion" pathways. CONCLUSIONS The prognostic signature defined by expression profiles of 12 survival-associated snoRNAs appears to be an excellent predictor of the clinical outcome of BLCA patients.

Ubiquitin‑specific‑processing protease 34 (USP34) is a deubiquitinase that is involved in the pathogenesis of various cancers. Its roles in diffuse large B‑cell lymphoma (DLBCL) are unknown. The present study aimed to determine the level of USP34 expression and to explore its association with clinicopathological features and prognosis in patients with DLBCL; a total of 30 cases of reactive lymphoid hyperplasia and 131 cases of DLBCL were included in this study. The level of USP34 expression was examined by immunohistochemistry (IHC), and correlations between USP34 expression and clinicopathological features and prognosis were analyzed. In addition, mutations, expression and clinical significance of USP34 in DLBCL were evaluated using data from The Cancer Genome Atlas (TCGA). USP34 expression was significantly higher in DLBCL compared with expression in reactive lymphoid hyperplasia. In DLBCL, overexpression of USP34 was associated with older age, germinal center B cell‑like (GCB) subtype, multiple extranodal involvements and higher International Prognostic Index (IPI) scores. No significant association was identified between USP34 protein level and patient survival. In the TCGA dataset, low USP34 mRNA expression was demonstrated to be associated with a poor disease‑free survival (DFS), but not with overall survival (OS) in patients with DLBCL. In conclusion, high expression of USP34 protein in DLBCL was associated with older age, GCB subtype, multiple extranodal involvement and high IPI scores of DLBCL. USP34 may be a valuable marker for the assessment of patients with DLBCL, and further studies are needed to clarify USP34 expression on DLBCLs.

The aim of this paper is to investigate the hesitant fuzzy linguistic multiple attribute decision making problems based on the hesitant fuzzy linguistic sets and Geometric Bonferroni mean operator. Then, we have proposed two aggregation operators: hesitant fuzzy linguistic geometric Bonferroni mean (HFLGBM) operator and hesitant fuzzy linguistic weighted geometric Bonferroni mean (HFLWGBM) operator. Then, we have utilized HFLWGBM operator to tackle the multiple attribute decision makingproblemsusinghesitantfuzzylinguisticinformation.Intheend,apracticalexampleforriskassessmentofmassunexpected incident in city is proposed to testify the method in this paper.

Aim of the study Previous studies in our laboratory revealed the neuroprotective effect of modified Yeoldahanso-tang (MYH) in models of Parkinson׳s disease (PD). In this study, we investigated another traditional Korean herbal formula, modified Chungsimyeolda-tang (termed DG), as a potential treatment for PD. Chungsimyeolda-tang has been used in Korea to treat cerebrovascular diseases, such as stroke. Here, we verify the neuroprotective and autophagy-inducing effects of DG to evaluate any potential anti-parkinsonian properties. Materials and methods 1-Methyl-4-phenylpyridinium (MPP + ) and rotenone were used to induce cytotoxicity in nerve growth factor (NGF)-differentiated rat pheochromocytoma (PC12) cells. Cell viability was measured using an MTT assay. Induction of autophagy by DG in NGF-differentiated PC12 cells was measured using an immunoblotting assay with an LC3 antibody. The proteasomal inhibitor lactacystin was used to induce ubiquitin-proteasome system (UPS) dysfunction in NGF-differentiated PC12 cells. DG-mediated clearance of aggregated proteins was measured using an immunoblotting assay with a ubiquitin antibody. Results and conclusions Our findings indicate that DG robustly protects NGF-differentiated PC12 cells against the neurotoxic effects of MPP + and rotenone in an in vitro model. Furthermore, DG protects NGF-differentiated PC12 cells against lactacystin-induced cell death. This effect is partially mediated by an increased autophagy associated with the enhanced degradation of aggregated proteins. This study suggests that DG is an attractive candidate drug for inducing autophagy and, therefore, may represent a promising strategy to prevent diseases associated with misfolded/aggregated proteins in various neurodegenerative disorders, including Parkinson׳s disease.

Reducing moisture in sewage sludge is one of the main goals of sewage sludge composting and biodrying. A mathematical model was used to simulate the performance of water removal under different aeration strategies. Additionally, the correlations between temperature, moisture content (MC), volatile solids (VS), oxygen content (OC), and ambient air temperature and aeration strategies were predicted. The mathematical model was verified based on coefficients of correlation between the measured and predicted results of over 0.80 for OC, MC, and VS, and 0.72 for temperature. The results of the simulation showed that water reduction was enhanced when the average aeration rate (AR) increased to 15.37 m(3) min(-1) (6/34 min/min, AR: 102.46 m(3) min(-1)), above which no further increase was observed. Furthermore, more water was removed under a higher on/off time of 7/33 (min/min, AR: 87.34 m(3) min(-1)), and when ambient air temperature was higher.

Foaming machine is a piece of important equipment in the production process of the foam concrete. This paper designed the control system with singlechip as the core of the digital processing. The communication between the singlechip and frequency converter was realized through RS485 port and the automatic control of the working process of the air compression double-bubble foaming machine can come true. The high performance-cost ratio of the single ratio enables the system control to be economical and practical; the touchscreen interface makes it simple to use; and the multi-gear setting also is easy to adjust and control. All these improve the overall performance of the foaming machine.

Helical rotor is a core component of helical-lobe compressor. Analysis was made on the geometrical properties of tooth curves. Using standard spherical milling cutter on 4-axis NC machine, normal migration method was used to rotor surface processing. Based on the generation characteristics of helical rotor surface, object-oriented design method is used to achieve automatic programming system of helical rotor. The calculation of helical rotor end face profile lines and cutter location point are realized, and over cutting analysis is carried out to generate high efficient numerical control processing program.

Absolute measuring principle of the high-speed rail was introduced to the measurement of existing speed rail. The line parameter reconstruction and long-wave smooth management is implemented. CPIII control points are laid along existing speed rail. Using the track fine-adjustment instrument, the center geodetic coordinates of midline of track were measured precisely. By least squares fitting method, parameters of straight line between curves was calculated. Plane curve were reconstructed based on measured geodetic coordinates of the continuous rail. The optimization results were used for the theoretical basis, and smoothness of 30 meters chord and 300 meters chord of rail were analyzed, and adjustments of plane curve were calculated to meet the long-wave smooth of rail.

This overview summarizes the application and impact of chemometrics on the extraction and interpretation of analytical data with the use of curve resolution methods from about 2005 onward. The development and usage of well-known and novel chemometric methods have been described and approximately 85 papers have been referenced. Many suggested improvements to some well-known methods, for example, multivariate curve resolution, have been noted as well as the growing software for such methods. Also, these high dimensional resolution methods have found significant application and, arguably, have opened up a new perspective in calibration, that is, extraction of otherwise unobtainable analytical information from strongly overlapping profiles in the presence of interferences. Recent literature suggests that the use of chemometric methods in analytical chemistry for data extraction and interpretation provides indispensable tools for multivariate data processing and extraction of hidden information, which otherwis...

IL-17–producing CD4+ T (Th17) cells have been found to be increased in some human cancers; however, the possible implication of Th17 cells in regulating antitumor responses in malignant pleural effusion (MPE) remains to be elucidated. In the current study, distribution and phenotypic features of Th17 cells in both MPE and peripheral blood from patients with lung cancer were determined by flow cytometry or double immunofluorescence staining. The impacts of cytokines on Th17 cell generation and differentiation were explored. The chemoattractant activity of chemokines CCL20 and CCL22 for Th17 cells in vitro was also observed. It was found that the increased Th17 cells could be found in MPE compared with blood. The in vitro experiments showed that IL-1β, IL-6, IL-23, or their various combinations could promote Th17 cell generation and differentiation from naive CD4+ T cells. MPE was chemotactic for Th17 cells, and this activity was partly blocked by anti-CCL20 and/or CCL22 Abs. Our data also showed that the accumulation of Th17 cells in MPE predicted improved patient survival. It could be concluded that the overrepresentation of Th17 cells in MPE might be due to Th17 cell differentiation and expansion stimulated by pleural proinflammatory cytokines and to recruitment of Th17 cells from peripheral blood induced by pleural chemokines CCL20 and CCL22. Furthermore, the accumulation of Th17 cells in MPE predicted improved patient survival. These data provide the basis for developing immune-boosting strategies based on ridding the cancer patient of this cell population.

FlexRay is a communication protocol that combines event- and time-triggered communication to increase the schedulability and flexibility of message scheduling in current car systems. Because safety and reliability are particularly crucial for automotive systems, the worst-case response times of signals transmitted by electronic control units must be under their deadlines. To increase the bandwidth utilization, the slotmultiplexing (SM) mechanism that is allowable in protocol specification was adopted to schedule messages offline in the dynamic segment of the FlexRay protocol, and this mechanism was also considered in the timing analysis. The proposed method was feasible to calculate worst-case response time of message under any bus load when considered slot-multiplexing. Then the approach was applied to a Society of Automotive Engineers benchmark to ensure that all messages were schedulable. The simulation results revealed that by using slot-multiplexing, only 17 identifiers were used, which was less than 23 identifiers that were needed when the slot-multiplexing was not considered. It also improved the schedulability of dynamic segment with up to 27% improvement in bus bandwidth utilization.

Resveratrol possesses anti-tumor activities against central nervous system (CNS) tumors in vitro but has not yet been used clinically due to its low bioavailability, particularly in the CNS. This study thus aimed to elucidate brain bioavailability of trans-resveratrol by monitoring brain concentrations and dwell times following administration of resveratrol through intragastric, intraperitoneal, external carotid artery/ECA and intrathecal routes. In parallel, we evaluated the biological responses of rat RG2 glioblastoma cells as well as RG2-formed rat intracranial glioblastomas treated with resveratrol via intrathecal administration. The results revealed that resveratrol was detected in rat brains except when administered systemically. Intrathecal administration of reseveratrol led to abundant apoptotic foci and increased staining of the autophagy proteins, LC-3 and Beclin-1 and shrinkage of the intracranial tumors. In conclusion, the BBB penetrability of resveratrol is remarkably increased by intracthecal administration. Regular short-term resveratrol treatments suppress growth and enhance autophagic and apoptotic activities of rat RG2 glioblastoma cells in vitro and in vivo. Therefore, intrathecal administration of resveratrol could be an optimal intervention approach in the adjuvant management of brain malignancies.

Controller area network (CAN) is widely used in automotive control systems as standard networks. However, the bandwidth limitation can not fulfil the communication requirement from increasing number of electronic components in vehicles. We propose to divide the nodes on the CAN buses into clusters. Communication cycles include the intra and inter communication time for transferring messages inside and between the clusters. The proposed method is called ClusterCAN which is a cyclic communication method based on CAN. ClusterCAN can transmit numerous messages simultaneously under proper clustering to enhance throughput. We provide the design concept of the bus segmentation and communication cycle for parallel transmission for the proposed ClusterCAN. Furthermore, the worst case response time analysis of the ClusterCAN is derived and used in the simulations. From the experimental results, the schedulable messages increase 50% and 75% under two and three clustering groups with the fixed inter connection ratio (10%) compared to the normal CAN

According to the theory of software architecture, the computer aided FMECA software model was analysis and established. On the basis of target and design strategy of FMECA, combined with Web Service technology, the web software model and database architecture of FMECA was constructed. Meanwhile, some key technology of FMECA was discussed.

Background To compare the compliance and efficacy among three treatment modalities in patients of type 2 diabetes with fairly good islet function. Methods This 38-month open, randomized, prospective study enrolled 536 subjects (HbA1c 9.4 ± 0.8%). Patients were divided into three groups including continual insulin injection (I), continual secretagogue administration (S) and alternation of two-month insulin injection and four-month secretagogue treatment (A). At baseline and every three months, HbA1c was measured and a standard bread meal test (100 g) was performed. Results HbA1c were better controlled in both groups I and A than in S (6.9 ± 0.3%, 6.8 ± 0.3% vs. 7.6 ± 0.5%). Hypoglycemia incidence was much lower in group A than that in I (0.8 times/patient/month vs. 2.4 times/patient/month) also with less weight gain (1.6 kg vs. 2.8 kg/patient/year). From the standard bread meal test, patients in group A got the greatest increment of 2-h C-peptide. Inquiry from all subjects showed that alternate strategy was welcomed by most of them considering for convenience and efficacy. Conclusions Alternate insulin–secretagogue treatment can effectively reduce HbA1c and help to improve islet function with reduced risk of hypoglycemia and weight gain under good compliance.

A case study of strength and vibration in aircraft turbine engines is included. Technical interactions of projects are explicitly considered. Fuzzy Isodata is used for measuring benefit contributions and technical interactions of projects. In the solution procedure, experiences and preferences of R&D managers are considered. The projects are fuzzily classified into five categories in terms of evaluations of the benefits and the interactions by using fuzzy Isodata. The manager obtains a number of feasible sets of projects by choosing and combining the two kinds of categories to be selected and then selects one set from the feasible sets while considering the restraints. The utility of this method is demonstrated in a case study that involved 23 project candidates. Evaluations were made by 30 experts. The results of the selection have been used by the manager. >

Ye, Z.-J., Q. Zhou, Y.-Y. Gu, S.-M. Qin, W.-L. Ma, J.-B. Xin, X.-N. Tao, and H.-Z. Shi. 2010. Generation and differentiation of IL-17–producing CD4+ T cells in malignant pleural effusion. J. Immunol. 185: [6348–6354][1]. The images published in [Fig. 5A][2] were mistakenly selected from