1. Atypical teratoid/rhabdoid tumor in adult: case series and an integrated survival analysis
- Author
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Ni Chen, Ya Xing Chen, Yi Cao, Jian Han Huang, Shu Cai Fan, Liangxue Zhou, and Ai Jun Peng
- Subjects
Oncology ,medicine.medical_specialty ,Series (stratigraphy) ,Chemotherapy ,business.industry ,medicine.medical_treatment ,Adult case ,General Medicine ,medicine.disease ,Radiation therapy ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Internal medicine ,Atypical teratoid rhabdoid tumor ,medicine ,Surgery ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,Survival analysis - Abstract
Atypical teratoid/rhabdoid tumor (AT/RT) is well documented in children but less so in adults because of its rarity.We report a series of five cases, a literature review and quantitative analysis of the survival outcome of adult AT/RT patients.Seventy-four patients including our five cases (male: female = 16: 58) were evaluated, whose median age was 32.5 years (18-80 years). The commonest location was the sellar region. Median overall survival (OS) was 12.5 months (0.5-204.00 months). Chemotherapy was associated with OS (HR: 0.349, 95%CI: 0.176-0.694,Adult AT/RT is commoner in females and tends to recur rapidly after surgical resection. Chemotherapy may provide a survival benefit. Surgery combined with postoperative chemotherapy and radiotherapy was associated with better prognosis for adult AT/RT patients, though the overall prognosis was still poor.
- Published
- 2021
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