1. Isoflavone biomarkers are inversely associated with atherosclerosis progression in adults: a prospective study
- Author
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Wenhua Ling, Yu-ming Chen, Meng Liu, Ting-yu Sun, Zhe-Qing Zhang, Luo-Shi-Yuan Zuo, Yu-Ping Liu, Feng Xiong, Chu-wen Ling, and Xin-Yi Tang
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Medicine (miscellaneous) ,Genistein ,Blood lipids ,030204 cardiovascular system & hematology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Sex hormone-binding globulin ,Internal medicine ,medicine ,cardiovascular diseases ,Prospective cohort study ,030109 nutrition & dietetics ,Nutrition and Dietetics ,biology ,business.industry ,Daidzein ,Equol ,Isoflavones ,Endocrinology ,Blood pressure ,chemistry ,biology.protein ,business - Abstract
BACKGROUND Many studies have examined associations between dietary isoflavones and atherosclerosis, but few used objective biomarkers. OBJECTIVES We examined the associations of isoflavone biomarkers (primary analyses) and equol production (secondary analyses) with the progression of carotid intima-media thickness (cIMT), and whether inflammation, systolic blood pressure (SBP), blood lipids, and sex hormone-binding globulin (SHBG) mediated these associations, in Chinese adults. METHODS This 8.8-y prospective study included 2572 subjects (40-75 y old) from the GNHS (Guangzhou Nutrition and Health Study; 2008-2019). The concentrations of daidzein, genistein, and equol were assayed by an HPLC-tandem MS in serum (n = 2572) at baseline and in urine (n = 2220) at 3-y intervals. The cIMT of the common carotid artery (CCA) and bifurcation segment were measured by B-mode ultrasound every 3 y, and the progressions of cIMT ( ∆cIMT) were estimated using the regression method. RESULTS Multivariable linear mixed-effects models (LMEMs) and ANCOVA revealed that subjects with higher serum isoflavones tended to have lower increases of CCA-cIMT. The mean ± SEM differences in 8.8-y ∆CCA-cIMT between extreme tertiles of serum isoflavones were -17.1 ± 8.4, -20.6 ± 8.3, and -23.3 ± 10.4 μm for daidzein, total isoflavone, and equol (P-trends
- Published
- 2021