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Breast cancer (BC) is the most common type of malignant tumor and the most common cause of cancer-related mortality among women. Metabolic reprogramming is considered a hallmark of cancer, and the study of BC metabolism may be the key to the development of new strategies for diagnosis and treatment. In this study, we aimed to explore the potential metabolites and gene biomarkers for BC through the integration of metabolomics and transcriptomic data, which could further understand BC tumor biology. Transcriptome dataset GSE139038 was downloaded to explore the differentially expressed genes (DEGs) between BC and normal control (NC) samples. Metabolomics dataset MTBLS326 was downloaded and preprocessed to obtain altered metabolites. Then, the principal component analysis (PCA) and linear models were used to reveal DEGs–metabolites relations. Finally, the pathway enrichment analysis of altered metabolites was performed. A total of 280 DEGs and eight metabolites were explored between BC and NC samples. The liner module analysis investigated 28 DEGs–metabolites interactions including WASP family member 3 (WASF3)–lactate, ras-related protein Rab-7B (RAB7B)–lactate, and methyltransferase-like 7A (METTL7A)–pyruvate. Finally, pathways analysis showed that these metabolites (such as lactate and pyruvate) were mainly enriched in pathways like disorders of the Krebs cycle. Combining with the transcriptomic and metabolomics data, we found that lactate, pyruvate, WASF3, RAB7B, and METTL7A might be used as novel biomarkers and potential therapeutic targets for BC. In addition, the disorders of the Krebs cycle pathway might affect the progression of BC.

A reasonable and effective macromolecular model of bituminous coal was established. The molecular dynamics method based on reactive force field (ReaxFF) was used to simulate the pyrolysis process of typical bituminous coal in the range of 1400–2600 K. The distribution of products and evolution of intermediate radicals were analyzed. Calculation results showed that with increase of pyrolysis temperature, yield of char firstly increased and then decreased, while the trend in tar production was opposite. Yield of pyrolysis gas increased monotonously with increasing temperature. The pyrolysis of coal at low temperature mainly experienced primary reaction with formation of tar free radical fragments and small molecular gases. At high temperature, the secondary reaction of tar fragments was remarkable, and char with more content but less quantity and small molecular gas with more content and quantity were produced. The temperature turning point from the primary reaction to the second one was 2000 K. Under the high temperature pyrolysis conditions, C and H in coal gradually migrated into char and tar, while oxygen-containing functional groups were more active, resulting in migration of O to pyrolysis gases. In the secondary reaction stage, comparing chemical properties of the three elements C, H and O, O was the most active, H was the second, and C was the most stable. H2O was firstly released during pyrolysis. NH3 mainly came from secondary reactions during which H2S was consumed and converted into other products. Yield of H2 was the highest, and increased with increasing pyrolysis temperature. A large amount of H2 was generated in secondary reactions, which was mainly from collision of hydrogen radicals generated from pyrolysis and condensation of aromatic structures. Based on ReaxFF simulation results, the weightless activation energy of coal pyrolysis was 39.45 kJ/mol.

In recent years, smart home has become one of the hottest topics in China, and smart window control system has become an indispensable part of smart home. In contemporary family, the window basically was daylighting, the only way that blocks dirt and ventilated take a breath, but also be the main way that enters a building illegally, put in significant safety hidden trouble. The intelligent window control system designed was controlled by a single chip microcomputer, integrated with a variety of sensors. It had the function of automatic closing to prevent slant rain from damaging indoor objects. The indoor harmful gas included natural gas, second-hand smoke, etc. These gas if exceed the limit would be dangerous, the smart window will automatically open. If thief enters a room, intelligent window could give an alarm automatically; The system would automatically monitor the indoor environment all the time. When the indoor temperature and humidity were above or below the set standard, the smart window would automatically adjust the switch state. Such intelligent window accomplished make the window real intelligence, the household life that gives people brought a lot of convenience, make the life quality of people further rise thereby.

Thyroid cancer is a common endocrine malignancy; however, surgery remains its primary treatment option. A novel targeted drug for the development and application of targeted therapy in thyroid cancer treatment remain underexplored. We obtained RNA sequence data of thyroid cancer from The Cancer Genome Atlas database and identified differentially expressed genes (DEGs). Then, we constructed co-expression network with DEGs and combined it with differentially methylation analysis to screen the key genes in thyroid cancer. PockDrug-Server, an online tool, was applied to predict the druggability of the key genes. Finally, we constructed protein-protein interaction (PPI) network to observe potential targeted drugs for thyroid cancer. We identified 3 genes correlated with altered DNA methylation level and oncogenesis of thyroid cancer. According to the druggable analysis and PPI network, we predicted TRAF2 and NCK-interacting protein kinase (TNIK) sever as the drug targeted for thyroid cancer. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis indicated that genes in protein-protein interaction network of TNIK enriched in mitogen-activated protein kinase signaling pathway. For drug repositioning, we identified a targeted drug of genes in PPI network. Our study provides a bioinformatics method for screening drug targets and provides a theoretical basis for thyroid cancer targeted therapy.

The intelligent home old-age service was an important way to solve the problem of current worsening old-age care reality in China[1-2]. An intelligent old-age home endowment monitoring system based on internet of things was proposed in this paper. The system has higher practical value, old-age health condition could be real-time monitored, the alerts could be sent when the unforeseen situation happened to the old man.

At present, the efficiency of livestock manure and crop residues is low in our country compared with international level. A massive array of automatic methane pond system is presented with controlled temperature and pressure. A single chip Micyoco( SCM) is the control unit. The motor is connected to the SCM; the transmission mechanism connected with the motor, the transmission chain is surrounded by a ring-shaped motor drive; loading of raw materials like iron grid mesh cage, rotates with the transmission chain.

In this paper, a novel light-absorpting shade and optical fiber and long persistent luminescent phosphor materials provided a safe and reliable day-and-night solar lighting system. It was not only save resource, reduce pollution, at the same time introduced solar light into the indoor to satisfy the lighting needs. The novel light-absorpting shade fabricated nanodiamond film to achieve the goal of self-cleaning,corrosion-resistant and corrosion-high temperature. This novel solar lighting system used of total reflection characteristic of optical fiber, and long persistent luminescent phosphor materials short storage time, high brightness to realize the purpose of day and night lighting.

Nano-SiC was mixed with nanocrystalline graphite and ethylic cellulose to paste. In order to fabricate Nano-SiC film electrode of super capacitor, a series of sol-gel Nano-SiC film with different proportions are designed test intentionally. Nano-SiC film was fixed on metal substrates using three-steps sintering process. The perovskite structure CaCu3Ti4O12 (of CCTO) ceramics has giant permittivity, low dielectric loss, good thermal stability and dielectric constant in a wide temperature range has very broad application prospects in microelectronics. In this paper, the solid state reaction sintering can be divided into two categories: sintering at 1373K at different times; first heating to 1423K then immediately cooling to 1373K and keeping for different times. The CCTO ceramic dielectric constant and dielectric loss decreased with frequency rises. A super capacitor was designed based on CCTO ceramics dielectric and Nano-SiC film electrode.

A novel cylinder-shaped structure field emission lighting tube (FELT) was fabricated. As an emission cathode the carbon nanotubes (CNTs) film were grown directly on the tungsten wire by pyrolysis of iron FePc, and were mounted by using elastic assembling technology. The model of electric field of this FELT was established. The electrons emitting characteristics of electronic field was measured. FELT can reach a static brightness of ~1.6x10^3cd/m^2 and can be operated at 180V. The turn-on field is 0.9V/@mm. When electronic field E=2.0V/@mm, the current density J=320A/m^2.

We fabricated a novel cylinder-shaped structure field emission light-emitting tube (FELET). As emission cathode the carbon nanotubes film is grown directly on the metallic wire by pyrolysis of iron FePc, and mounted the emission cathode with elastic assembling technology. The electrons emitting characteristics of electronic field is measured. SEM image of the CNTs shows that many branches at carbon nanotubes top. The emission mechanism of this new kind carbon nanotubes was careful researched. The forecasting model of wavelet neural networks forecasting results show that the absolute value of the relative error of the model is within 5.00%.

In this paper, novel top branched carbon nanotube (TBCNT) were discovered by the scanning electron microscopy (SEM) and transmission electron microscopy (TEM). This new kind TBCNT was grown directly on tungsten wire by pyrolysis of FePc. At 1123 K FePc can be decompounded into C, Fe and other elements, the deposition site of C atom was calculated when FePc be decompound in test, and the growth of TBCNT was experimented according the result of calculation. The growth technique of TBCNT was carefully researched. The bifurcate mechanism was analyzed according the crystal and dynamical theories. The field emission characteristic of the TBCNT film was measured, the measured result indicated that the TBCNT film cathode can be used as traffic pilot signals, colored message or a pixel of giant screen display. Using the TBCNT film cathode, we fabricated a novel cylinder-shaped structure field emission lighting tube (FELT)