1. Identification of dyslipidemia as a risk factor for sudden sensorineural hearing loss: A multicenter case‐control study
- Author
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Wangqiang Hu, Xiaoqing Li, Binghua Chen, Yumin Wang, Fan Ye, and Xingxing Zhou
- Subjects
Male ,Apolipoprotein B ,Clinical Biochemistry ,Blood lipids ,Logistic regression ,Gastroenterology ,Risk Factors ,Immunology and Allergy ,Child ,Research Articles ,Aged, 80 and over ,biology ,Incidence ,Hematology ,Lipoprotein(a) ,Middle Aged ,Prognosis ,Lipids ,sudden sensorineural hearing loss ,Lipoproteins, LDL ,Medical Laboratory Technology ,Apolipoprotein B-100 ,lipids (amino acids, peptides, and proteins) ,Research Article ,Adult ,Microbiology (medical) ,medicine.medical_specialty ,Adolescent ,Hearing Loss, Sensorineural ,Young Adult ,Internal medicine ,medicine ,Humans ,Risk factor ,Triglycerides ,Aged ,Dyslipidemias ,Apolipoprotein A-I ,case‐control study ,business.industry ,dyslipidemia ,Biochemistry (medical) ,Public Health, Environmental and Occupational Health ,Case-control study ,medicine.disease ,Case-Control Studies ,biology.protein ,business ,Dyslipidemia ,Lipoprotein - Abstract
Background Recently, several studies have reported an association between lipid profiles and sudden sensorineural hearing loss (SSNHL), yet there is considerable variability between the individual studies in defining the precise association between serum lipids levels and SSNHL. This study sought to identify a possible relationship between dyslipidemia and the prevalence and prognosis of SSNHL. Methods A case‐control study was carried out at two independent medical centers, including 2,288 SSNHL patients and 2,288 healthy controls. Clinical characteristics and serum lipid parameters were assessed, including total cholesterol (CHOL), high‐density lipoprotein (HDL), low‐density lipoprotein (LDL), triglycerides (Trig), apolipoprotein AI (ApoAI), apolipoprotein B (ApoB), and lipoprotein a (Lpa). Multivariate logistic regression analysis was performed to assess the relationship between lipid profiles and SSNHL in the 4,576 subjects. Results Significant differences were identified in several conventional serum lipid markers including CHOL, Trig, HDL, LDL, ApoAI, ApoB, and Lpa, between SSNHL patients and healthy controls. Serum ApoAI levels were significantly lower in patients with bilateral SSNHL compared to unilateral SSNHL. Binary logistic regression analysis revealed that higher levels of ApoB, LDL, Trig, and lower levels of ApoAI and HDL were all associated with an increased risk of SSNHL. After clinical characterization, multivariate analysis showed that only low levels of ApoB predicted likelihood of a recovery of more than 30 dB among patients with SSNHL. Conclusions Serum lipids are associated with the incidence and prognosis of SSNHL. Identification of dyslipidemia may improve early evaluation and management of SSNHL risks., Binary logistic regression analysis of various lipids and SSNHL risk. Although CHOL and Lpa concentrations differed significantly between SSNHL patients and control subjects, neither the CHOL nor Lpa was related to SSNHL in multivariate analysis. Subjects with ApoB levels 5.54‐fold (95% CI 4.11–7.47) higher than that of healthy controls were more likely to have SSNHL pathology. Patients with abnormal LDL and Trig levels had a 10% (1.10 (1.03–1.18)) and 29% (1.29 (1.22–1.35)) increased odds of having SSNHL compared with healthy controls. Levels of ApoAI in patients with SSNHL were significantly lower (0.16 (0.13–0.21)) than that of control subjects. Conversely, HDL levels of control subjects were lower than those observed in patients with SSNHL (0.67 (0.56–0.80)).
- Published
- 2021
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