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Serum uric acid level has been found to be associated with cerebrovascular diseases. However, whether serum uric acid level is a risk factor for arterial stiffness in the hypertension population is unclear. This study was designed to determine the relationship between serum uric acid level and arterial stiffness in the hypertension population. A total of 10450 participants were evaluated for the risk of arterial stiffness. Brachial-ankle pulse wave velocity (baPWV) was assessed, and high baPWV was determined as the highest quartile of baPWV values in a sex-specific manner. We evaluated the association between serum uric acid level and baPWV through multivariate-adjusted linear and logistic regression analyses. There was a significant difference on high baPWV between patients with quartiles of serum uric acid level in females and males (p

Dental implant recipients often have other oral diseases such as head and neck (H&N) cancer, Sjogren’s syndrome (SS), or oral lichen planus (OLP) that may compromise implant treatment. Surgical resection of H&N cancer often results in critical defect in available residual bone, and radiotherapy may lead to implant failure. Bone grafting reconstruction and zygomatic or short implants were suggested when planning the implant insertion. At the same time, optimizing the dose and frequency of radiotherapy, hyperbaric oxygen therapy, as well as locally administering growth factors could help to reduce implant failure. As a chronic autoimmune disease, Sjogren’s syndrome patients may lose their teeth early due to destructive dental caries and/or periodontal problems. Implant treatment is preferred to restore these missing teeth when compared to conventional removable partial denture. However, xerostomia-diminished quality and quantity of saliva may influence the implant osseointegration. When it comes to oral lichen planus, comprehensive preoperative evaluation of the patient and close postoperative monitor of OLP clinical evolution are recommended. Surgical strategies and restorative considerations along with prosthesis maintenance are discussed in detail in this chapter as follows.

In this study, we investigate the pull-out performance of bolted joints of pultruded fiber reinforced polymer (PFRP) profile specimens with drilled and punched holes, respectively, and investigate the effects of different resin matrices and different fiber directions on the pull-out performance of the bolted joints. The experiment results show that the pull-out performance of the bolted joints in the uni-axial polyurethane-based PFRP is better than that in the uni-axial unsaturated polyester resin-based PFRP. The pull-out capacity of bolted joints on the multi-axial PFRP specimens with drilled holes is better than that of bolted joints in the uni-axial PFRP specimens with drilled holes. The multi-axial fiber can effectively prevent longitudinal splitting of pultruded profiles and significantly improve their pull-out performance. The punching process has little impact on the pull-out performance of bolted joints in the uni-axial PFRP specimens. However, it greatly undermines the pull-out performance of the bolt hole of the multi-axial PFRP specimens. Finally, using the progressive damage analysis (PDA) model, and combined with the Hashin failure criteria, we establish a model by means of the C3D8R solid elements in ABAQUS to simulate the pull-out mechanical behavior of the bolted joints.

Backgroud Familial adenomatous polyposis (FAP) is an autosomal dominant-inherited colorectal cancer (CRC) with poor prognosis, and is also considered as model to study the change of CRC from pre-tumor to tumor progression. To better predict and guide clinical applications of immune check point inhibitors(ICI), researchers proposed the classification system of human cancer, termed tumor immunity in the microenvironment (TIME), that four different TIME groups have been identified according to the presence of TILs and B7-H1(PD-L1) expression in tumor biopsies. Therefore, we followed and performed this theory into our research about TIME of FAP, to explore the potential of immunotherapy for FAP, and explore the cancerous mechanism from immune microenvironment. Methods We collected tissue samples of 40 FAP patients from May 2009 to December 2018, followed by detection of PD-L1 by using Dako PD-L1 IHC 22C3 pharmDx, MLH1, PMS2, MSH2, MSH6 were detected by IHC, and CD8+ T cells, tumor associated macrophages (TAM) and NK cells infiltration in the tumor biopsies by multiple fluorescence immunohistochemistry (mICH). Follow-up data of these 40 patients were analyzed. Results CD8+T cells, M1 and M2 TAM, CD56bright NK and CD56dim NK cells were found both in intratumoral region and tumor rim of FAP patients(n=40), no differences have been found between M1and M2 TAM, however, CD56dim NK increased more than CD56bright NK both in intratumoral region and tumor rim(p Conclusions For the TIME characteristics of FAP patient, Immunotherapy targeted PD-1/PD-L1 may not applicable for FAP, however, MLH1, the member of mismatch repair protein, was associated with infiltration of NK cells, especially CD56dim NK cells in the tumor, and also associated with prognosis of FAP patients. Therefore, it can be exploited as potential target of immunotherapy for FAP or even CRC. Citation Format: Jun Yang, Hushan Zhang, Wei Qing Liu, Wenliang Li, Shumin Ma, Lei Liang, Zhiyong Kou, Depei Huang, Xudong Shen, Jian Dong. Infiltration of CD56dim NK cells regulated by MLH1 into tumor tissue of FAP patients predict better prognosis [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 3871.

In this paper, a new approach based on the continuum model is proposed to estimate the main cable tension force of suspension bridges from measured natural frequencies. This approach considered the vertical vibration of a main cable hinged at both towers and supported by an elastic girder and hangers along its entire length. The equation reflected the relationship between vibration frequency and horizontal tension force of a main cable was derived. To avoid to generate the additional cable tension force by sag-extensibility, the analytical solution of characteristic equation for anti-symmetrical vibration mode of the main cable was calculated. Then, the estimation of main cable tension force was carried out by anti-symmetric characteristic frequency vector. The errors of estimation due to characteristic frequency deviations were investigated through numerical analysis of the main cable of Taizhou Bridge. A field experiment was conducted to verify the proposed approach. Through measuring and analyzing the responses of a main cable of Taizhou Bridge under ambient excitation, the horizontal tension force of the main cable was identified from the first three odd frequencies. It is shown that the estimated results agree well with the designed values. The proposed approach can be used to conduct the long-term health monitoring of suspension bridges.

In this paper, an experiment in a quasi-static conditions was carried out on barge bow model with its cross sections simplified. The characteristics of the bow structure were studied experimentally and Finite Element Analysis (FEA) was conducted to compare with experimental results. The experiment was performed by a compression and shear testing machine and the model was axially collapsed by a rigid board. The collapse mechanisms, load-displacement curve and mean crushing strength were investigated. The study showed that basic collapse mechanism of barge bow was clarified in participates with inner diaphragms. Moreover, the accuracy of FEA to estimate mean crushing force were validated by comparing with experimental results.

In this paper, the free nonlinear sloshing of liquid in a rigid partially liquid-filled cylindrical container with a rigid annular baffle is investigated. The liquid domain is firstly divided into four simple sub-domains so that the liquid velocity potential in each sub-domain has continuous boundary conditions of class $$\hbox {C}^{1}$$ . Then, based on the Bateman–Luke variational principle, the equivalent variational formulation of the free boundary problem for the liquid in a baffled container is derived. By introducing the generalized time-dependent coordinates, the surface wave height and the velocity potential are expanded in the form of generalized Fourier series. Substituting the series expression of surface wave height and velocity potential into the variational formulation enables us to obtain the infinite dimensional modal system. Finally, based on the Moiseev asymptotic relations, the infinite dimensional modal system is reduced to a finite dimensional modal system. Good agreements have been achieved by comparing the present results with those obtained from the Gavrilyuk’s solutions. The effects of baffle parameters and initial conditions on the nonlinear sloshing of liquid are discussed in detail.

The combination of Rayleigh’s energy method and Southwell’s frequency composition method denoted the fundamental vibration frequencies of the freestanding pylon of suspension bridges as the composition of several subsystem frequencies. The subsystems consisted of deformation and inertia components. Thus, the algorithm for calculating the fundamental vibration frequency of the freestanding pylon of suspension bridges was derived through the rational selection of the deflection function. Take the middle steel pylon of Taizhou Bridge as a calculation example. The impact of top additional mass ratio, structure shear deformation, and vibration of the bearing platform on fundamental vibration frequency was analyzed. The numerical calculation and real bridge field vibration test show that (1) the fundamental vibration frequency of the pylon decreases as top additional mass ratio increases, and (2) the vibration of the bearing platform should not be ignored even if ignoring shear deformation only has a sl...

This paper presents an accurate analytical method to obtain the rocking impedance function of a surface-supported strip foundation. The Green’s functions of the elastic half-space under concentrated or uniform loads with infinite length are derived and an elaborate integration method is used to calculate the multi-value improper integral. The interface between the foundation and the supporting medium is divided into a number of strip units. The rocking impedance function is solved by adding the moments in every strip, based on the fact that the vertical displacement of each unit can be uniquely determined by the rotation amplitude of the rigid foundation. Excellent convergence has been observed. Comparing the numerical results to those obtained by the thin layer method, good agreements are achieved. Finally, the effect of the Poisson’s ratio on the rocking impedance function of the strip foundation is discussed in detail.

Explosion inside the entrance of a tunnel may produce strong blast wave in the tunnel. Taking effective measures to attenuate the air blast wave is very important. Numerical simulations were done on explosion inside the entrance of a tunnel in three different cases, no baffles, symmetrical baffles and stagger baffles arranged along the tunnel. It is found that the arrangement of baffles can attenuate the air blast wave effectively. The best arrangement of baffles is given and it is a reference for tunnel protective design and study.

A new composite structure system is proposed in this paper to suit the demand of building energy conservation and heat preservation. Based on the low reversed cyclic loading test, the non-linear finite element (FEM) analysis model of composite shear wall is established by ANSYS so as to study crack status, stress variation characteristics and failure process under the action of horizontal loading. The results of ANSYS finite element analysis show good agreement with the test results.

In this paper, a total of five structural insulated panel shear walls (SIPSW), in which with plywood facing and polystyrene foam board core, were tested under low cyclic horizontal loading. For the test specimens, different wall depth-width ratio and the opening sizes have been considered. The failure modes, failure mechanics, bearing capacity, lateral stiffness and ductility are discussed in detail. The test results showed that the hysteretic curve of SIPSW shows a reversed S-shape. Also the depth-to-width ratio and the opening dimensions of the shear walls have significant effects on load bearing capacity, ductility and elastic stiffness. What’s more, the performance of the SIPSW specimens was controlled by the fastener slip behavior of the SIP-to-spline connection, especially along the bottom spline. Finally, it is indicated that SIPSW have a good satisfaction upon seismic performance when used to timber structures.

An overall outline is given for the development of the glued laminated timber structures in China. Different types of glulam structures built in recent years, such as gymnasium, bridges, public buildings, traditional architecture, landscape structures have been discussed. During the development of glulam structure in the future, raising design and produce level will be the most important question we confront and should be settled.

A simple and efficient direct displacement-based design (DDBD) method is introduced to base isolated (BI) structures. Assuming the vibration mode of superstructure to be the shear type and considering the BI structure to be an equivalent single degree of freedom (ESDOF) system with spring and damper at the seismic isolation layer. The acceleration response spectrum in Chinese code is converted to displacement response spectrum. Corresponding to the design displacement, the equivalent period is obtained. The relationship of the deign displacement, equivalent period, equivalent stiffness and base shear of the system can be derived from the given formulations. Then, the distribution of the base shear along the floors is obtained. This method has been applied to the design of a 12-story BI structure with lead rubber bearings in high intensity zone in Suqian city, Jiangsu province. The results show that the method is feasible for the design of BI structures.

Sloshing response of liquid in a rigid cylindrical tank with a rigid annual baffle under horizontal sinusoidal loads was studied. The effect of the damping was considered in the analysis. Natural frequencies and modes of the system have been calculated by using the Sub-domain method. The total potential function under horizontal loads is assumed to be the sum of the tank potential function and the liquid perturbed function. The expression of the liquid perturbed function is obtained by introducing the generalized coordinates. Substituting potential functions into the free surface wave conditions, the dynamic response equations including the damping effect are established. The damping ratio is calculated by Maleki method. The liquid potential are obtained by solving the dynamic response equations of the system.

This paper puts attention on the application of Chebyshev complex polynomials in the development of lumped-parameter model of surface circular foundation. The present method is an important extension to the concept of polynomial-fraction approximation in the foundation modeling. In the present analysis, the normalized flexibility function is adopted to improve the accuracy of the model and to reduce the parameters in modeling. The accuracy and validity of the lumped-parameter model is extensively investigated for the case of surface circular foundation. The proposed method may be easily applied to analyze various practical problems in soil-structure interaction such as vibration of machines on foundation and response of structures under earthquake.

Seven groups, total of 31 single-bolted steel-glulam-steel joints, were tested for their mechanical performance. The mechanical properties of single-bolted steel-glulam-steel connection subjected to a load parallel to the grain have been studied. The failure mode and failure mechanism of bolted connections were discussed in detail. It is shown that the failure mode, bearing capacity, stiffness and ductility of the joint are mainly relative to the thickness of the glulam and the diameter of the bolt. Due to the wide application of bolted steel-glulam-steel connections in engineering, the present work can be taken as a reference in manufacture, and design of modern timber structures.

A new modified model for assessing the effects of SSI on base-isolated structures is presented from the case of conventional structures. The equations of motion of the equivalent fixed-base 2-DOF system are formulated in frequency domain. Based on this, rigorous and closed-form formulations for fundamental period and composite damping are derived. Finally, analysis of parameters based on frequency independent coefficients in detail is conducted. The analytical model and method presented can serve to assess the effects of SSI in the design of base-isolated structures including high-rise structures. Significant differences between the system with and without radiation damping and the flexibility of supporting soil have been observed in this study. For the results of the analysis, overall SSI effects have been identified as elongation of fundamental period of the system and decreased composite damping, especially for the high-rise and slender isolated structures.

Paulownia wood was drilled with some glass fibers fulfilled in the holes, which could be the core of the sandwich structures. In the manufacture processing, the fibers and resins left in the holes formed composite columns and merged with the facesheets. These could enhance the mechanical behavior of paulownia wood sandwich structures. Double cantilever beam(DCB) tests and bending analysis with finite element method were carried out. The improvement from the composite columns gave little contribution to bending behavior, but significant contribution to interfacial properties.

Rectal perforation is an unusual complication of therapeutic colonoscopy. The present study reports the case of a patient with a rare manifestation of pneumothorax, pneumomediastinum, pneumoperitoneum and extensive subcutaneous emphysema that resulted from an endoscopic mucosal resection following a colonoscopy of the rectum. Only 3 cases of colonic perforation and 1 case of rectal perforation have been described previously, of which the clinical diagnoses and treatments were varied, and no results of follow-up studies were reported. In the present study, dyspnea and neck swelling were acute signs of extraluminal air that resulted from rectal perforation. Computed axial tomography was an effective diagnosis method, and is recommended for the early recognition of colorectal perforation. Appropriate management and a close follow-up are crucial for optimal results.