1. Risk of infection according to the gamma globulin level in the 100 days following allogeneic stem cell transplantations
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Aline Schmidt, Aurelien Giltat, Jean-Baptiste Robin, Jérémie Riou, Valentin Lacombe, Mathilde Hunault, Valérie Ugo, Pierre Abgueguen, Christopher Nunes Gomes, Sylvie François, Sylvain Thepot, Valérie Daniel, Corentin Orvain, Xavier Dieu, Laurane Cottin, Service des maladies du sang [Angers], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Fédérations hospitalo-universitaires Grand Ouest Acute Leukemia [Angers] (FHU GOAL), Innate Immunity and Immunotherapy (CRCINA-ÉQUIPE 7), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Département de Biochimie et Génétique [Angers], Université d'Angers (UA)-Centre Hospitalier Universitaire d'Angers (CHU Angers), Service d'hématologie [Angers], Service des maladies infectieuses et tropicales [CHU Angers], Département de Pharmacie [CHU d'Angers], Micro et Nanomédecines Translationnelles (MINT), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Bernardo, Elizabeth, and Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)
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Male ,Transplantation Conditioning ,Lymphoma ,medicine.medical_treatment ,Graft vs Host Disease ,gamma-globulins ,Hematopoietic stem cell transplantation ,Gastroenterology ,Hypogammaglobulinemia ,0302 clinical medicine ,Leukemia ,biology ,Risk of infection ,Immunoglobulins, Intravenous ,Gamma globulin ,Bacterial Infections ,Hematology ,General Medicine ,Middle Aged ,Prognosis ,3. Good health ,030220 oncology & carcinogenesis ,hematopoietic stem cell transplantation ,Cyclosporine ,Female ,Antibody ,Stem cell ,Immunosuppressive Agents ,allografts ,medicine.medical_specialty ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Opportunistic Infections ,03 medical and health sciences ,Immune system ,[SDV.CAN] Life Sciences [q-bio]/Cancer ,Internal medicine ,medicine ,Humans ,Transplantation, Homologous ,Aged ,business.industry ,infections ,Immunologic Deficiency Syndromes ,Mycophenolic Acid ,Myeloablative Agonists ,medicine.disease ,Increased risk ,Mycoses ,ROC Curve ,Myelodysplastic Syndromes ,biology.protein ,Virus Activation ,business ,030215 immunology - Abstract
International audience; Background: Immunoglobulin replacement therapy is recommended in case of severe hypogammaglobulinemia after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, the supposed increased risk of infection in case of hypogammaglobulinemia has not been confirmed in allo-HSCT. In this study, we assessed the relationship between the gamma globulin level and the risk of infection during the 100 days following the allo-HSCT.Methods: We gathered the weekly laboratory tests from day 7 to day 100 of 76 allograft patients, giving a total of 1 044 tests. 130 infections were documented clinically, by imaging, or microbiologically.Results: Average gamma globulin levels between D-7 and D100 did not differ between patients with or without infection (642 ± 232 and 671 ± 246 mg/dL, respectively, P = .65). Gamma globulin level
- Published
- 2021
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